Journal ArticleDOI
.alpha.-Methoxy-.alpha.-trifluoromethylphenylacetic acid, a versatile reagent for the determination of enantiomeric composition of alcohols and amines
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This article is published in Journal of Organic Chemistry.The article was published on 1969-09-01. It has received 2312 citations till now. The article focuses on the topics: Reagent.read more
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Enantioselective Synthesis of Polyfunctional Small Building Blocks with a Quaternary Stereogenic Center
Dieter Enders,Andreas Zamponi,Thomas Schäfer,Christoph Nübling,Herbert Eichenauer,Ayhan S. Demir,Gerhard Raabe +6 more
TL;DR: The SAMP/RAMP-hydrazone method offers an efficient and flexible access to compounds with a quaternary stereogenic center, such as silyl, thio, phenyl, aldo, keto, ester and alkyl functionalities as mentioned in this paper.
Journal ArticleDOI
Total synthesis of optically active integerrimine, a twelve-membered dilactonic pyrrolizidine alkaloid of retronecine type
Haruki Niwa,Y. Miyachi,Osamu Okamoto,Youichi Uosaki,Akio Kuroda,Hiroyuki Ishiwata,Kiyoyuki Yamada +6 more
TL;DR: A total synthesis of the natural enantiomer of integerrimine (1), a twelve-membered dilactonic pyrrolizidine alkaloid of retronecine type has been achieved through the enantioselective synthesis and regiose-lective coupling of (+)-retronecines (4) and (+)-integerrinecic acid (methylthio)methyl ether (6) as discussed by the authors.
Journal ArticleDOI
1H-nuclear magnetic resonance determination of the enantiomeric purity of aliphatic primary amines, β-aminoalcohols, β-diamines and α-amino-acids with 1R-(−)-myrtenal: scope and limitations
TL;DR: In this article, 1R-(−)-myrtenal was tested as a chiral derivatising agent for the determination of the enantiomeric purity of aliphatic primary amines, β-amino alcohols and β-diamines.
Journal ArticleDOI
Diastereo‐ and enantioselective synthesis of the 18‐membered lichen macrolide (+)‐aspicilin
Dieter Enders,Oleg F. Prokopenko +1 more
TL;DR: The asymmetric synthesis of the lichen macrolide (+)-aspicilin (1) was realised in 19 steps and with high stereoselectivity (de ≥ 91 %, ee ≥ 96%) by employing the SAMP/RAMP hydrazone method.
Journal ArticleDOI
Total synthesis of (+)-disparlure
TL;DR: The title compound was synthesized from 2,3 O -isopropylidene-D -glyceraldehyde (3 ) using highly syn-selective L-Selectride reduction of alkoxyketone 4.
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Nuclear magnetic resonance enantiomer regents. Configurational correlations via nuclear magnetic resonance chemical shifts of diastereomeric mandelate, O-methylmandelate, and .alpha.-methoxy-.alpha.-trifluoromethylphenylacetate (MTPA) esters
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