Journal ArticleDOI
.alpha.-Methoxy-.alpha.-trifluoromethylphenylacetic acid, a versatile reagent for the determination of enantiomeric composition of alcohols and amines
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This article is published in Journal of Organic Chemistry.The article was published on 1969-09-01. It has received 2312 citations till now. The article focuses on the topics: Reagent.read more
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A new method for the enantioselective synthesis of N-Boc-α,α-disubstituted α-amino acids
TL;DR: In this paper, a new method for the enantioselective synthesis of N-Boc-α,α-disubstituted α-amino acids has been developed.
Journal ArticleDOI
A convergent strategy towards taxol. A facile enantioselective entry into a fully functionalized ring A system
TL;DR: In this paper, the taxol ring A system has been synthesized in enantiomerically pure form by a short and efficient route featuring a Diels-Alder reaction and a Corey oxazaborolidine reduction.
Journal ArticleDOI
Asymmetric Synthesis of the Both Enantiomers of α-Hydroxy Acids by the Diastereoselective Reduction of Chiral α-Keto Amides with (Complex) Metal Hydrides in the Presence of Metallic Salt
TL;DR: In this article, the effects of the metallic salts and the reducing reagents in the diastereoselective reduction of chiral α-keto amides derived from (S)-proline methyl ester were examined.
Journal ArticleDOI
Substrate specificity and enantioselectivity of penicillinacylase catalyzed hydrolysis of phenacetyl esters of synthetically useful carbinols
TL;DR: Penicillinacylase from Ecoli, immoblized on Eupergit C beads catalyzes the hydrolysis in water/CH 3 CN 10:1, at pH 75 and 23° C, of a set of O-phenylacetate esters of primary carbinols as discussed by the authors.
Journal ArticleDOI
Stereoselective Synthesis of Highly Functionalized Cyclopropanes. Application to the Asymmetric Synthesis of (1S,2S)-2,3-Methanoamino Acids
Philippe Dorizon,Guifa Su,Gitte Ludvig,Lilyia Nikitina,Renée Paugam,Jean Ollivier,Jacques Salaün +6 more
TL;DR: Molecular mechanics calculations using a modified MM2 type force field adapted to the pi-allyl palladium complexes have explained the reversibility of the palladium-catalyzed cyclization step, responsible for the low enantioselectivity observed and for the formation of byproducts, i.e., azepine derivatives 8a,b arising from subsequent aza Cope ring expansion.
Related Papers (5)
Nuclear magnetic resonance enantiomer regents. Configurational correlations via nuclear magnetic resonance chemical shifts of diastereomeric mandelate, O-methylmandelate, and .alpha.-methoxy-.alpha.-trifluoromethylphenylacetate (MTPA) esters
James A. Dale,Harry S. Mosher +1 more