Journal ArticleDOI
.alpha.-Methoxy-.alpha.-trifluoromethylphenylacetic acid, a versatile reagent for the determination of enantiomeric composition of alcohols and amines
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This article is published in Journal of Organic Chemistry.The article was published on 1969-09-01. It has received 2312 citations till now. The article focuses on the topics: Reagent.read more
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Enantioselective diethylzinc addition to aldehydes using azetidine-derived chiral catalysts
TL;DR: High levels of enantioselectivity have been achieved in the diethylzinc addition to both aromatic and aliphatic aldehydes, employing readily available N-substituted-azetidinyl(diphenylmethyl)methanols as chiral catalysts.
Journal ArticleDOI
Phylogeny-guided isolation of ethyl tumonoate A from the marine cyanobacterium cf. Oscillatoria margaritifera.
Niclas Engene,Hyukjae Choi,Eduardo Esquenazi,Tara Byrum,Francisco A. Villa,Zhengyu Cao,Thomas F. Murray,Pieter C. Dorrestein,Pieter C. Dorrestein,Lena Gerwick,William H. Gerwick,William H. Gerwick +11 more
TL;DR: The evolutionary relationships of cyanobacteria, as inferred by their SSU (16S) rRNA genes, were used as predictors of their potential to produce varied secondary metabolites and discovered ethyl tumonoate A, a new tumonoic acid derivative with anti-inflammatory activity and inhibitory activity of calcium oscillations in neocortical neurons.
Journal ArticleDOI
Diastereoselectivity in conjugate addition of alkylcuprates to vinylogous ester of N O-diprotected serinal.
TL;DR: In this article, various alkylcuprates were added to the Z and E vinylogous esters of N,O-diprotected (D) or (L) serinal 1.
Journal ArticleDOI
Asymmetric autocatalysis triggered by oxygen isotopically chiral glycerin
Arimasa Matsumoto,Shotaro Oji,Shizuka Takano,Kyohei Tada,Tsuneomi Kawasaki,Tsuneomi Kawasaki,Kenso Soai +6 more
TL;DR: Chiral (S)- and (R)-(18)O-glycerin induces enantioselective addition of diisopropylzinc to pyrimidine-5-carbaldehyde, and the subsequent asymmetric autocatalysis affords (R-S)-pyrimidyl alkanol with high enantiomeric excess, respectively.
Journal ArticleDOI
Conjugate addition of nitrogen nucleophiles to an α, β-unsaturated pyrrolidinone
TL;DR: The conjugate addition of nitrogen nucleophiles to α,β-unsaturated lactam 1b under very mild conditions occurs in good yield with high diastereoselectivity as mentioned in this paper.
Related Papers (5)
Nuclear magnetic resonance enantiomer regents. Configurational correlations via nuclear magnetic resonance chemical shifts of diastereomeric mandelate, O-methylmandelate, and .alpha.-methoxy-.alpha.-trifluoromethylphenylacetate (MTPA) esters
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