Journal ArticleDOI
.alpha.-Methoxy-.alpha.-trifluoromethylphenylacetic acid, a versatile reagent for the determination of enantiomeric composition of alcohols and amines
About:
This article is published in Journal of Organic Chemistry.The article was published on 1969-09-01. It has received 2312 citations till now. The article focuses on the topics: Reagent.read more
Citations
More filters
Journal ArticleDOI
Synthesis and absolute configuration of the acetalic lignan (+)-phrymarolin I.
Fumito Ishibashi,Eiji Taniguchi +1 more
TL;DR: The natural (+)-phrymarolin I was stereoselectively synthesized and its absolute configuration was unequivocally determined as being (1S,2S,5R,6S)-1-acetoxy-2-(2-methoxy-4,5-methylenedioxyphenoxy)-6-(2.methoxyl)-4.5-methyltenedioxyclo[3.3.0]octane.
Journal ArticleDOI
Diastereo- and Enantioselective Synthesis of Vicinal Amino Alcohols by Oxa Michael Addition of N-Formylnorephedrine to Nitro Alkenes
TL;DR: The first intermolecular asymmetric oxa Michael additions with removable chirality information within the hydroxide source are reported and transition states explaining the overall stereochemical outcome are presented.
Journal ArticleDOI
Chiral Propargyl Alcohols via the Enantioselective Addition of Terminal Di- and Triynes to Aldehydes
Erin R. Graham,Rik R. Tykwinski +1 more
TL;DR: Modification of the Carreira alkynylation protocol shows that addition of diynes and triynes to α-branched aldehydes can be complete in as little as 4 h, and these reactions give good yields and enantioselectivities.
Journal ArticleDOI
Allyl bromide, a powerful inhibitor against R-enzyme activities in Bakers' yeast reduction of ethyl 3-oxoalkanoates
TL;DR: Allyl bromide strongly suppressed R-enzyme activities in Bakers' yeast-catalyzed reduction of ethyl 3-oxo-pentanoate to give unusual ethyl l-(S)-(+)-3-hydroxypentanoate in a high enantiomeric excess of ≥98%, while the control reaction without any additive gave d-(R)-(−)-enantiomer (3) in 40–50% ee.
Journal ArticleDOI
Preparation of (S)-2,3-dichloro-1-propanol by Pseudomonas sp. and its use in the synthesis of (R)-epichlorohydrin
TL;DR: Pseudomonas sp. as discussed by the authors assimilated (R)-2,3-dichloro-1-propanol preferentially as the sole source of carbon.
Related Papers (5)
Nuclear magnetic resonance enantiomer regents. Configurational correlations via nuclear magnetic resonance chemical shifts of diastereomeric mandelate, O-methylmandelate, and .alpha.-methoxy-.alpha.-trifluoromethylphenylacetate (MTPA) esters
James A. Dale,Harry S. Mosher +1 more