Journal ArticleDOI
.alpha.-Methoxy-.alpha.-trifluoromethylphenylacetic acid, a versatile reagent for the determination of enantiomeric composition of alcohols and amines
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This article is published in Journal of Organic Chemistry.The article was published on 1969-09-01. It has received 2312 citations till now. The article focuses on the topics: Reagent.read more
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β-fluoroamphetamines via the stereoselective synthesis of benzylic fluorides
Alexander J. Cresswell,Stephen G. Davies,James A. Lee,Paul M. Roberts,Angela J. Russell,James E. Thomson,Melloney J. Tyte +6 more
TL;DR: A range of substituted aryl epoxides undergo efficient ring-opening hydrofluorination upon treatment with 0.33 equiv of BF(3) x OEt(2) in CH(2), consistent with a mechanism involving a stereoselective S(N)1-type epoxide ring- opening process.
Journal ArticleDOI
Total synthesis and revision of C6 stereochemistry of (+)-amphidinolide W.
Arun K. Ghosh,Gangli Gong +1 more
TL;DR: An enantioselective first total synthesis and structural revision of the cytotoxic natural product amphid inolide W is described, and the C6 absolute stereochemistry of amphidinolides W has now been revised through the synthesis.
Journal ArticleDOI
Chiral precursors for the synthesis of enantiomerically pure piperidines. Total synthesis of (R)-(-)-coniine
TL;DR: In this paper, the preparation of chiral cis-and trans-oxazolopiperidones 1, 2, and 3 by alternative procedures and an efficient synthesis of the piperidine alkaloid (R )-(-)-coniine from trans-1 is reported.
Journal ArticleDOI
Non-proteinogenic amino acid synthesis. The β-anion derived from aspartic acid, and its application to α-amino acid synthesis
TL;DR: In this article, α- t -Butyl β-methyl N -Z-(S)-aspartate (2) with lithium amide bases generates the corresponding β-ester enolate, which can be alkylated with suitable electrophiles.
Journal ArticleDOI
Preparation d'alkyl-4 γ-lactones optiquement actives
Jean-Pierre Vigneron,V. Bloy +1 more
TL;DR: In this article, the enantiomers of 4-alkyl γ-lactones are synthesized from optically active propargylic carbinols obtained by asymmetric reduction of α-acetylenic ketones with the chiral complex.
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Nuclear magnetic resonance enantiomer regents. Configurational correlations via nuclear magnetic resonance chemical shifts of diastereomeric mandelate, O-methylmandelate, and .alpha.-methoxy-.alpha.-trifluoromethylphenylacetate (MTPA) esters
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