Journal ArticleDOI
Effects of Intermittent Fasting on Health, Aging, and Disease
Rafael de Cabo,Mark P. Mattson +1 more
TLDR
Effects of Intermittent Fasting on Health and Aging evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base fasting.Abstract:
Effects of Intermittent Fasting on Health and Aging Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base...read more
Citations
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Journal ArticleDOI
OUP accepted manuscript
TL;DR: In this paper , the association of habitual prolonged nightly fasting with a wide array of cardiovascular, renal, inflammation, and nutritional status biomarkers among community-dwelling older adults was assessed.
Journal ArticleDOI
Is there a Role of the Obstetrician and Gynaecologist in Recognising, Preventing, and Managing Obesity in Indian Context?
TL;DR: India’s childhood obesity risk score stands at 4/11 and the chances of meeting the WHO standards for 2025 are almost nil and a recent report concluded that obesity was on the rise in the country.
Journal ArticleDOI
Intermittent fasting alleviates type 1 diabetes-induced cognitive dysfunction by improving the frontal cortical metabolic disorder.
Fen Xiong,Kaiyuan Jiang,Yali Wu,Cong Lou,Chenxin Ding,Xi Zhang,Chen Li,Hong Zheng,Hongchang Gao +8 more
TL;DR: Intermittent fasting (IF) is an ecological strategy to control various metabolic disorder symptoms, but its protective effect on type 1 diabetes (T1D)-induced cognitive dysfunction and the underlying mechanisms remain poorly defined as discussed by the authors .
Posted ContentDOI
Ketosis Prevents Abdominal Aortic Aneurysm Rupture Through CCR2 Downregulation and Enhanced MMP Balance
Sergio Sastriques-Dunlop,Santiago Elizondo-Benedetto,Batool Arif,Rodrigo Meade,Mohamed S. Zaghloul,Sean J. English,Yongjian Liu,Mohamed A. Zayed +7 more
TL;DR: In this paper , the authors evaluated whether systemic in vivo ketosis can impact CCR2 signaling, and therefore impact abdominal aortic aneurysms (AAAs) expansion and rupture.
References
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Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Ricki J. Colman,Rozalyn M. Anderson,Sterling C. Johnson,Erik K. Kastman,Kristopher J. Kosmatka,T. Mark Beasley,David B. Allison,Christina Cruzen,Heather A. Simmons,Joseph W. Kemnitz,Richard Weindruch +10 more
TL;DR: Findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research demonstrate that CR slows aging in a primate species.
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Risk of dementia in diabetes mellitus: a systematic review
TL;DR: The findings of mechanistic studies suggest that vascular disease and alterations in glucose, insulin, and amyloid metabolism underlie the pathophysiology of dementia, but which of these mechanisms are clinically relevant is unclear.
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Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet
Megumi Hatori,Christopher Vollmers,Amir Zarrinpar,Amir Zarrinpar,Luciano DiTacchio,Eric A. Bushong,Shubhroz Gill,Mathias Leblanc,Amandine Chaix,Matthew S. Joens,James A. J. Fitzpatrick,Mark H. Ellisman,Satchidananda Panda +12 more
TL;DR: Mice under tRF consume equivalent calories from HFD as those with ad lib access yet are protected against obesity, hyperinsulinemia, hepatic steatosis, and inflammation and have improved motor coordination.
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Starvation in man.
TL;DR: In this article, it was shown that decreased levels of active T3 may play a role by sparing otherwise obligated calories by decreasing metabolic needs, but this can be nullified by amino acid or protein supplementation.
Journal ArticleDOI
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network.
TL;DR: The results point to a central role for the PGC-1 family in integrating mitochondrial biogenesis and energy production with many diverse cellular functions.