Journal ArticleDOI
Effects of Intermittent Fasting on Health, Aging, and Disease
Rafael de Cabo,Mark P. Mattson +1 more
TLDR
Effects of Intermittent Fasting on Health and Aging evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base fasting.Abstract:
Effects of Intermittent Fasting on Health and Aging Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base...read more
Citations
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Journal ArticleDOI
Autophagy in healthy aging and disease
Yahyah Aman,Yahyah Aman,Tomas Schmauck-Medina,Malene Hansen,Richard I. Morimoto,Anna Katharina Simon,Ivana Bjedov,Konstantinos Palikaras,Anne Simonsen,Anne Simonsen,Terje Johansen,Nektarios Tavernarakis,Nektarios Tavernarakis,David C. Rubinsztein,Linda Partridge,Linda Partridge,Guido Kroemer,John Labbadia,Evandro Fei Fang +18 more
TL;DR: A recent review as discussed by the authors examines several emerging features of autophagy and postulates how they may be linked to aging as well as to the development and progression of disease, and discusses current preclinical evidence arguing for the use of auto-ophagy modulators as suppressors of age-related pathologies such as neurodegenerative diseases.
Journal ArticleDOI
Effects of 4- and 6-h Time-Restricted Feeding on Weight and Cardiometabolic Health: A Randomized Controlled Trial in Adults with Obesity.
Sofia Cienfuegos,Kelsey Gabel,Faiza Kalam,Mark Ezpeleta,Eric Wiseman,Vasiliki Pavlou,Shuhao Lin,Manoela Lima Oliveira,Krista A. Varady +8 more
TL;DR: It is suggested that 4- and 6-h TRF induce mild reductions in body weight over 8 weeks and show promise as interventions for weight loss and may also improve some aspects of cardiometabolic health.
Journal ArticleDOI
NAFLD and cardiovascular diseases: a clinical review.
Philipp Kasper,Anna Martin,Sonja Lang,Fabian Kütting,Tobias Goeser,Münevver Demir,Hans-Michael Steffen +6 more
TL;DR: The underlying pathophysiological mechanisms linking NAFLD and CVD are described, the role ofNAFLD as a metabolic dysfunction associated cardiovascular risk factor is discussed, and common cardiovascular manifestations in NAFLd patients are focused on.
Journal ArticleDOI
A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks
Evandro Fei Fang,Chenglong Xie,Chenglong Xie,Joseph Adam Schenkel,Chenkai Wu,Qian Long,Honghua Cui,Yahyah Aman,Johannes Frank,Jing Liao,Huachun Zou,Huachun Zou,Ninie Y. Wang,Jing Wu,Xiaoting Liu,Li Tao,Fang Yuan,Zhangming Niu,Guang Yang,Jiangshui Hong,Qian Wang,Guobing Chen,Jun Li,Hou-Zao Chen,Lin Kang,Huanxing Su,Brian C. Gilmour,Xinqiang Zhu,Hong Jiang,Na He,Tao Jun,Sean Xiao Leng,Tanjun Tong,Jean Woo +33 more
TL;DR: Collectively, synergies across disciplines on policies, geriatric care, drug development, personal awareness, the use of big data, machine learning and personalized medicine will transform China into a country that enables the most for its elderly, maximizing and celebrating their longevity in the coming decades.
Journal ArticleDOI
Dietary Strategies for Metabolic Syndrome: A Comprehensive Review
Sara Castro-Barquero,Sara Castro-Barquero,Ana María Ruiz-León,Ana María Ruiz-León,Maria Sierra-Pérez,Ramon Estruch,Ramon Estruch,Rosa Casas,Rosa Casas +8 more
TL;DR: On comparing low-fat and restricted diets, the scientific evidence supports the use of the Mediterranean Dietary Approaches to Stop Hypertension (DASH) diet intervention as the new paradigm for metabolic syndrome prevention and treatment.
References
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Journal ArticleDOI
Caloric restriction and cancer: molecular mechanisms and clinical implications
TL;DR: New findings suggest a beneficial effect of CR in enhancing the efficiency of tumor cell killing by chemotherapeutic drugs and inducing an anticancer immune response.
Journal ArticleDOI
Calories, carbohydrates, and cancer therapy with radiation: exploiting the five R’s through dietary manipulation
Rainer J. Klement,Colin E. Champ +1 more
TL;DR: It is concluded that CR and KDs may act synergistically with radiation therapy for the treatment of cancer patients and some guidelines for implementing these dietary interventions into clinical practice are provided.
Journal ArticleDOI
Studies in the Ketosis of Fasting
TL;DR: The possibility is raised that the ketosis of fasting is due to a direct activation of acetoacetate-synthesizing enzymes secondary to a starvation-induced depression of insulin secretion by the pancreas.
Journal ArticleDOI
Effect of intermittent vs. daily calorie restriction on changes in weight and patient-reported outcomes in people with multiple sclerosis.
Kathryn C. Fitzgerald,Diane Vizthum,Bobbie J. Henry-Barron,Amy Schweitzer,Sandra D. Cassard,Eric H. Kossoff,Adam L. Hartman,Dimitrios Kapogiannis,Patrick Sullivan,David J. Baer,Mark P. Mattson,Lawrence J. Appel,Ellen M. Mowry +12 more
TL;DR: CR diets are a safe/feasible way to achieve weight loss in people with MS and may be associated with improved emotional health.
Journal ArticleDOI
The effect of short-term fasting on liver and skeletal muscle lipid, glucose, and energy metabolism in healthy women and men.
TL;DR: In this article, the authors measured liver and muscle triglyceride (TG) content and metabolism in women and men during a 48-hour fast in healthy men and women and found that postabsorptive plasma fatty acids (FAs) were higher in women than in men but increased more rapidly in men with the onset of early starvation.