Journal ArticleDOI
Effects of Intermittent Fasting on Health, Aging, and Disease
Rafael de Cabo,Mark P. Mattson +1 more
TLDR
Effects of Intermittent Fasting on Health and Aging evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base fasting.Abstract:
Effects of Intermittent Fasting on Health and Aging Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base...read more
Citations
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Journal ArticleDOI
The effects of age and systemic metabolism on anti-tumor T cell responses.
TL;DR: Current knowledge of how age and systemic metabolic state affect the anti-tumor immune response is reviewed, with an emphasis on CD8+ T cells, which are key players in anti-Tumor immunity.
Journal ArticleDOI
Competing paradigms of obesity pathogenesis: energy balance versus carbohydrate-insulin models
David S. Ludwig,Caroline M. Apovian,Louis J. Aronne,Arne Astrup,Lewis C. Cantley,Cara B. Ebbeling,Steven B. Heymsfield,James D. Johnson,Janet C. King,R. Krauß,Gary Taubes,Jeff S. Volek,Eric C. Westman,Walter C. Willett,William S. Yancy,Mark I. Friedman +15 more
TL;DR: In this article , a new formulation of the energy balance model (EBM), like prior versions, considers overeating (energy intake > expenditure) the primary cause of obesity, incorporating an emphasis on complex endocrine, metabolic, and nervous system signals that control food intake below conscious level.
Journal ArticleDOI
Metabolic Impact of Intermittent Fasting in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis of Interventional Studies.
Emily Borgundvaag,Jessica Mak,Jessica Mak,Caroline K. Kramer,Caroline K. Kramer,Caroline K. Kramer +5 more
TL;DR: Current evidence suggests that IF is associated with greater weight loss in patients with T2DM as compared with standard diet, with similar impact on glycemic control.
Journal ArticleDOI
Visceral Adiposity and Cancer: Role in Pathogenesis and Prognosis
TL;DR: In this paper, the relationship between obesity and cancer has been investigated, highlighting the biological mechanisms at the basis of this link, and strategies to remodel fat, including browning and lifestyle interventions, have been taken into consideration as a major perspective to limit excess body weight and tumor onset.
Journal ArticleDOI
Nutritional basis of type 2 diabetes remission.
TL;DR: Roy Taylor and colleagues as mentioned in this paper explained how type 2 diabetes can be reversed by weight loss and avoidance of weight regain, which can be achieved by avoiding weight re-recurvability.
References
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Journal ArticleDOI
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Ricki J. Colman,Rozalyn M. Anderson,Sterling C. Johnson,Erik K. Kastman,Kristopher J. Kosmatka,T. Mark Beasley,David B. Allison,Christina Cruzen,Heather A. Simmons,Joseph W. Kemnitz,Richard Weindruch +10 more
TL;DR: Findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research demonstrate that CR slows aging in a primate species.
Journal ArticleDOI
Risk of dementia in diabetes mellitus: a systematic review
TL;DR: The findings of mechanistic studies suggest that vascular disease and alterations in glucose, insulin, and amyloid metabolism underlie the pathophysiology of dementia, but which of these mechanisms are clinically relevant is unclear.
Journal ArticleDOI
Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet
Megumi Hatori,Christopher Vollmers,Amir Zarrinpar,Amir Zarrinpar,Luciano DiTacchio,Eric A. Bushong,Shubhroz Gill,Mathias Leblanc,Amandine Chaix,Matthew S. Joens,James A. J. Fitzpatrick,Mark H. Ellisman,Satchidananda Panda +12 more
TL;DR: Mice under tRF consume equivalent calories from HFD as those with ad lib access yet are protected against obesity, hyperinsulinemia, hepatic steatosis, and inflammation and have improved motor coordination.
Journal ArticleDOI
Starvation in man.
TL;DR: In this article, it was shown that decreased levels of active T3 may play a role by sparing otherwise obligated calories by decreasing metabolic needs, but this can be nullified by amino acid or protein supplementation.
Journal ArticleDOI
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network.
TL;DR: The results point to a central role for the PGC-1 family in integrating mitochondrial biogenesis and energy production with many diverse cellular functions.