Journal ArticleDOI
Effects of Intermittent Fasting on Health, Aging, and Disease
Rafael de Cabo,Mark P. Mattson +1 more
TLDR
Effects of Intermittent Fasting on Health and Aging evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base fasting.Abstract:
Effects of Intermittent Fasting on Health and Aging Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base...read more
Citations
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Journal ArticleDOI
Autophagy in healthy aging and disease
Yahyah Aman,Yahyah Aman,Tomas Schmauck-Medina,Malene Hansen,Richard I. Morimoto,Anna Katharina Simon,Ivana Bjedov,Konstantinos Palikaras,Anne Simonsen,Anne Simonsen,Terje Johansen,Nektarios Tavernarakis,Nektarios Tavernarakis,David C. Rubinsztein,Linda Partridge,Linda Partridge,Guido Kroemer,John Labbadia,Evandro Fei Fang +18 more
TL;DR: A recent review as discussed by the authors examines several emerging features of autophagy and postulates how they may be linked to aging as well as to the development and progression of disease, and discusses current preclinical evidence arguing for the use of auto-ophagy modulators as suppressors of age-related pathologies such as neurodegenerative diseases.
Journal ArticleDOI
Effects of 4- and 6-h Time-Restricted Feeding on Weight and Cardiometabolic Health: A Randomized Controlled Trial in Adults with Obesity.
Sofia Cienfuegos,Kelsey Gabel,Faiza Kalam,Mark Ezpeleta,Eric Wiseman,Vasiliki Pavlou,Shuhao Lin,Manoela Lima Oliveira,Krista A. Varady +8 more
TL;DR: It is suggested that 4- and 6-h TRF induce mild reductions in body weight over 8 weeks and show promise as interventions for weight loss and may also improve some aspects of cardiometabolic health.
Journal ArticleDOI
NAFLD and cardiovascular diseases: a clinical review.
Philipp Kasper,Anna Martin,Sonja Lang,Fabian Kütting,Tobias Goeser,Münevver Demir,Hans-Michael Steffen +6 more
TL;DR: The underlying pathophysiological mechanisms linking NAFLD and CVD are described, the role ofNAFLD as a metabolic dysfunction associated cardiovascular risk factor is discussed, and common cardiovascular manifestations in NAFLd patients are focused on.
Journal ArticleDOI
A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks
Evandro Fei Fang,Chenglong Xie,Chenglong Xie,Joseph Adam Schenkel,Chenkai Wu,Qian Long,Honghua Cui,Yahyah Aman,Johannes Frank,Jing Liao,Huachun Zou,Huachun Zou,Ninie Y. Wang,Jing Wu,Xiaoting Liu,Li Tao,Fang Yuan,Zhangming Niu,Guang Yang,Jiangshui Hong,Qian Wang,Guobing Chen,Jun Li,Hou-Zao Chen,Lin Kang,Huanxing Su,Brian C. Gilmour,Xinqiang Zhu,Hong Jiang,Na He,Tao Jun,Sean Xiao Leng,Tanjun Tong,Jean Woo +33 more
TL;DR: Collectively, synergies across disciplines on policies, geriatric care, drug development, personal awareness, the use of big data, machine learning and personalized medicine will transform China into a country that enables the most for its elderly, maximizing and celebrating their longevity in the coming decades.
Journal ArticleDOI
Dietary Strategies for Metabolic Syndrome: A Comprehensive Review
Sara Castro-Barquero,Sara Castro-Barquero,Ana María Ruiz-León,Ana María Ruiz-León,Maria Sierra-Pérez,Ramon Estruch,Ramon Estruch,Rosa Casas,Rosa Casas +8 more
TL;DR: On comparing low-fat and restricted diets, the scientific evidence supports the use of the Mediterranean Dietary Approaches to Stop Hypertension (DASH) diet intervention as the new paradigm for metabolic syndrome prevention and treatment.
References
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Journal ArticleDOI
Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia.
Devin Wahl,Sean C. P. Coogan,Sean C. P. Coogan,Samantha M. Solon-Biet,Rafael de Cabo,James B Haran,David Raubenheimer,Victoria C. Cogger,Mark P. Mattson,Stephen J. Simpson,David G. Le Couteur +10 more
TL;DR: Dietary interventions have been shown to influence various cognitive and behavioral tests in rodents indicating that nutrition can influence brain aging and possibly neurodegeneration.
Journal ArticleDOI
The life-extending effect of dietary restriction requires Foxo3 in mice
Isao Shimokawa,Toshimitsu Komatsu,Nobutaka Hayashi,Sang Eun Kim,Takuya Kawata,Seongjoon Park,Hiroko Hayashi,Haruyoshi Yamaza,Takuya Chiba,Ryoichi Mori +9 more
TL;DR: The results indicate the necessity of Foxo3 for lifespan extension but not cancer suppression by DR, and suggest differential regulation of cancer and lifespan by DR via Foxo1 and Foxo 3.
Journal ArticleDOI
Improvement in coronary heart disease risk factors during an intermittent fasting/calorie restriction regimen: Relationship to adipokine modulations.
Cynthia M. Kroeger,Monica C. Klempel,Surabhi Bhutani,John F. Trepanowski,Christine C. Tangney,Krista A. Varady +5 more
TL;DR: It is suggested that IFCR with a liquid diet favorably modulates visceral fat and adipokines in a way that may confer protection against CHD.
Journal ArticleDOI
Protein and Calorie Restriction Contribute Additively to Protection from Renal Ischemia Reperfusion Injury Partly via Leptin Reduction in Male Mice
Lauren Robertson,J. Humberto Treviño-Villarreal,Pedro Mejia,Yohann Grondin,Eylul Harputlugil,Christopher Hine,Dorathy Vargas,Hanqiao Zheng,C. Keith Ozaki,Bruce S. Kristal,Stephen J. Simpson,James R. Mitchell +11 more
TL;DR: In male mice, PR and CR both contributed to the benefits of short-term DR against renal IRI independent of GCN2 but partially dependent on reduced circulating leptin and coincident with AMPK activation and mTORC1 repression.
Journal ArticleDOI
Intermittent Fasting Improves Functional Recovery after Rat Thoracic Contusion Spinal Cord Injury
Mi-ae Jeong,Ward T. Plunet,Femke Streijger,Jae H.T. Lee,Jason R. Plemel,Sophia Park,Clarrie K. Lam,Jie Liu,Wolfram Tetzlaff +8 more
TL;DR: It is reported that alternating periods of fasting (but not pair-fed) also promotes improved hindlimb locomotion after thoracic spinal cord contusion, demonstrating its robust effect in two different injury models.