Journal ArticleDOI
Effects of Intermittent Fasting on Health, Aging, and Disease
Rafael de Cabo,Mark P. Mattson +1 more
TLDR
Effects of Intermittent Fasting on Health and Aging evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base fasting.Abstract:
Effects of Intermittent Fasting on Health and Aging Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base...read more
Citations
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Journal ArticleDOI
Eating, diet, and nutrition for the treatment of NAFLD.
TL;DR: In this article , a comprehensive overview of dietary concepts to counteract the increasing burden of NAFLD was provided, emphasizing the importance of dietary calorie restriction independently of the macronutrient composition together with adherence to a Mediterranean diet.
Journal ArticleDOI
Pegylated arginine deiminase drives arginine turnover and systemic autophagy to dictate energy metabolism
TL;DR: In this paper , the authors demonstrate that arginine iminohydrolysis by the bacterial virulence factor and arcA, promoted mammalian energy expenditure and insulin sensitivity and reverses dyslipidemia, hepatic steatosis, and inflammation in obese mice.
Journal ArticleDOI
Evidence that overnight fasting could extend healthy lifespan
TL;DR: A feeding schedule of prolonged overnight fasting periods extends healthy lifespan in fruit flies by promoting night-time autophagy, a process in which material in cells is degraded and recycled.
Journal ArticleDOI
Associations of diarised sleep onset time, period and duration with total and central adiposity in a biethnic sample of young children: the Born in Bradford observational cohort study.
TL;DR: The Born in Bradford 1000 study as discussed by the authors investigated associations of parent-reported sleep characteristics with adiposity levels in a biethnic sample of young children and found that later sleep onset was associated with lower BMI z-score (−0.5 to −0.0) and sum of two-skinfolds (−1.5 mm to −2.1 cm).
Journal ArticleDOI
Intermittent fasting supports the balance of the gut microbiota composition
Hikmet Taner Teker,Taha Ceylani +1 more
TL;DR: Analysis results showed that the preferred intermittent fasting program helps balance the GM composition, an important example showing the strong positive link between intermittent fasting and GM.
References
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Journal ArticleDOI
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Ricki J. Colman,Rozalyn M. Anderson,Sterling C. Johnson,Erik K. Kastman,Kristopher J. Kosmatka,T. Mark Beasley,David B. Allison,Christina Cruzen,Heather A. Simmons,Joseph W. Kemnitz,Richard Weindruch +10 more
TL;DR: Findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research demonstrate that CR slows aging in a primate species.
Journal ArticleDOI
Risk of dementia in diabetes mellitus: a systematic review
TL;DR: The findings of mechanistic studies suggest that vascular disease and alterations in glucose, insulin, and amyloid metabolism underlie the pathophysiology of dementia, but which of these mechanisms are clinically relevant is unclear.
Journal ArticleDOI
Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet
Megumi Hatori,Christopher Vollmers,Amir Zarrinpar,Amir Zarrinpar,Luciano DiTacchio,Eric A. Bushong,Shubhroz Gill,Mathias Leblanc,Amandine Chaix,Matthew S. Joens,James A. J. Fitzpatrick,Mark H. Ellisman,Satchidananda Panda +12 more
TL;DR: Mice under tRF consume equivalent calories from HFD as those with ad lib access yet are protected against obesity, hyperinsulinemia, hepatic steatosis, and inflammation and have improved motor coordination.
Journal ArticleDOI
Starvation in man.
TL;DR: In this article, it was shown that decreased levels of active T3 may play a role by sparing otherwise obligated calories by decreasing metabolic needs, but this can be nullified by amino acid or protein supplementation.
Journal ArticleDOI
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network.
TL;DR: The results point to a central role for the PGC-1 family in integrating mitochondrial biogenesis and energy production with many diverse cellular functions.