Journal ArticleDOI
Effects of Intermittent Fasting on Health, Aging, and Disease
Rafael de Cabo,Mark P. Mattson +1 more
TLDR
Effects of Intermittent Fasting on Health and Aging evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base fasting.Abstract:
Effects of Intermittent Fasting on Health and Aging Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base...read more
Citations
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Journal ArticleDOI
Brain-Gut-Microbiome Interactions and Intermittent Fasting in Obesity.
TL;DR: In this article, the effects of time-restricted eating on the brain-gut-microbiome (BGM) system were discussed and the promising effects of this eating pattern in obesity treatment were reviewed.
Journal ArticleDOI
Intermittent Fasting Improves Lipid Metabolism Through Changes in Gut Microbiota in Diet-Induced Obese Mice.
TL;DR: IF can improve fat metabolism, reduce fat accumulation, promote white fat conversion to beige, and improve gut microbiota.
Journal ArticleDOI
The effects of Ramadan intermittent fasting on liver function in healthy adults: A systematic review, meta-analysis, and meta-regression.
TL;DR: In this article, a systematic review and meta-analysis was conducted to estimate the effect size for changes in liver function tests (LFT) in healthy people practicing Ramadan diurnal intermittent fasting (RDIF), and to examine the impact of different covariates using subgroup analysis and metaregression.
Journal ArticleDOI
Late-life intermittent fasting decreases aging-related frailty and increases renal hydrogen sulfide production in a sexually dimorphic manner
Yoko O Henderson,Nazmin Bithi,Christopher D. Link,Jie Yang,Rebecca C. Schugar,Natalia C. Llarena,Natalia C. Llarena,J. Mark Brown,Christopher Hine +8 more
TL;DR: In this paper, the effects of EOD fasting on renal H2S production capacity and its connection to frailty in males were investigated in 20-month-old male and female C57BL/6 mice.
Journal ArticleDOI
Downregulation of Keap1 Confers Features of a Fasted Metabolic State
Elena V. Knatko,Michael H. Tatham,Ying Zhang,Cecilia Castro,Maureen Higgins,Sharadha Dayalan Naidu,Chiara Leonardi,Laureano de la Vega,Tadashi Honda,Julian L. Griffin,Julian L. Griffin,Ronald T. Hay,Albena T. Dinkova-Kostova,Albena T. Dinkova-Kostova +13 more
TL;DR: It is shown that genetic downregulation of Keap1 in mice, and the consequent Nrf2 activation to pharmacologically relevant levels, leads to upregulation of carboxylesterase 1 and acyl-CoA oxidase 2, decreases triglyceride levels, and alters the lipidome.
References
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Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Ricki J. Colman,Rozalyn M. Anderson,Sterling C. Johnson,Erik K. Kastman,Kristopher J. Kosmatka,T. Mark Beasley,David B. Allison,Christina Cruzen,Heather A. Simmons,Joseph W. Kemnitz,Richard Weindruch +10 more
TL;DR: Findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research demonstrate that CR slows aging in a primate species.
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Risk of dementia in diabetes mellitus: a systematic review
TL;DR: The findings of mechanistic studies suggest that vascular disease and alterations in glucose, insulin, and amyloid metabolism underlie the pathophysiology of dementia, but which of these mechanisms are clinically relevant is unclear.
Journal ArticleDOI
Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet
Megumi Hatori,Christopher Vollmers,Amir Zarrinpar,Amir Zarrinpar,Luciano DiTacchio,Eric A. Bushong,Shubhroz Gill,Mathias Leblanc,Amandine Chaix,Matthew S. Joens,James A. J. Fitzpatrick,Mark H. Ellisman,Satchidananda Panda +12 more
TL;DR: Mice under tRF consume equivalent calories from HFD as those with ad lib access yet are protected against obesity, hyperinsulinemia, hepatic steatosis, and inflammation and have improved motor coordination.
Journal ArticleDOI
Starvation in man.
TL;DR: In this article, it was shown that decreased levels of active T3 may play a role by sparing otherwise obligated calories by decreasing metabolic needs, but this can be nullified by amino acid or protein supplementation.
Journal ArticleDOI
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network.
TL;DR: The results point to a central role for the PGC-1 family in integrating mitochondrial biogenesis and energy production with many diverse cellular functions.