Journal ArticleDOI
Effects of Intermittent Fasting on Health, Aging, and Disease
Rafael de Cabo,Mark P. Mattson +1 more
TLDR
Effects of Intermittent Fasting on Health and Aging evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base fasting.Abstract:
Effects of Intermittent Fasting on Health and Aging Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base...read more
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Journal ArticleDOI
Methionine restriction - Association with redox homeostasis and implications on aging and diseases
Yuyu Zhang,Julia Jelleschitz,Tilman Grune,Weixuan Chen,Yihang Zhao,Mengzhen Jia,Yajie Wang,Annika Höhn,Zhigang Liu +8 more
TL;DR: In this article , the effects of methionine restriction on lifespan, age-related implications, comorbidities, and diseases are discussed, as well as the association of methions metabolism pathways with redox homeostasis is described.
Journal ArticleDOI
The effect of energy restriction on development and progression of chronic kidney disease: review of the current evidence.
TL;DR: Energy restriction has a positive impact on experimental kidney ageing, CKD, and acute kidney injury through such mechanisms as increased autophagy, mitochondrial biogenesis and DNA repair, and decreased inflammation and oxidative stress.
Journal ArticleDOI
Time-restricted feeding and circadian autophagy for long life.
Hong Long,Satchidananda Panda +1 more
TL;DR: In this article, a novel intermittent time-restricted feeding (iTRF) dietary regimen was used to extend the healthy lifespan of Drosophila, and a clock-dependent nightly rise in autophagy drove the lifespan benefits of iTRF.
Journal ArticleDOI
Time-restricted feeding and cognitive function in sedentary and physically active elderly individuals: Ramadan diurnal intermittent fasting as a model
M. Boujelbane,Khaled Trabelsi,Haitham Jahrami,Liwa Masmoudi,Achraf Ammar,Aïmen Khacharem,Omar Boukhris,Luca Puce,Sergio Garbarino,Egeria Scoditti,Saber Khanfir,Soulaimane Akrout,Ahmed Hakim,Nicola Luigi Bragazzi,Kelsey Bryk,Jordan M. Glenn,Hamdi Chtourou +16 more
TL;DR: In this article , the effects of diurnal intermittent fasting on cognitive performance, sleep quality, daytime sleepiness, and insomnia in physically active and sedentary elderly individuals were investigated, and the results indicated that older adults who continue to train at least three times per week during Ramadan may improve their cognitive performance despite the impairment of sleep quality.
References
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Journal ArticleDOI
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Ricki J. Colman,Rozalyn M. Anderson,Sterling C. Johnson,Erik K. Kastman,Kristopher J. Kosmatka,T. Mark Beasley,David B. Allison,Christina Cruzen,Heather A. Simmons,Joseph W. Kemnitz,Richard Weindruch +10 more
TL;DR: Findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research demonstrate that CR slows aging in a primate species.
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Risk of dementia in diabetes mellitus: a systematic review
TL;DR: The findings of mechanistic studies suggest that vascular disease and alterations in glucose, insulin, and amyloid metabolism underlie the pathophysiology of dementia, but which of these mechanisms are clinically relevant is unclear.
Journal ArticleDOI
Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet
Megumi Hatori,Christopher Vollmers,Amir Zarrinpar,Amir Zarrinpar,Luciano DiTacchio,Eric A. Bushong,Shubhroz Gill,Mathias Leblanc,Amandine Chaix,Matthew S. Joens,James A. J. Fitzpatrick,Mark H. Ellisman,Satchidananda Panda +12 more
TL;DR: Mice under tRF consume equivalent calories from HFD as those with ad lib access yet are protected against obesity, hyperinsulinemia, hepatic steatosis, and inflammation and have improved motor coordination.
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Starvation in man.
TL;DR: In this article, it was shown that decreased levels of active T3 may play a role by sparing otherwise obligated calories by decreasing metabolic needs, but this can be nullified by amino acid or protein supplementation.
Journal ArticleDOI
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network.
TL;DR: The results point to a central role for the PGC-1 family in integrating mitochondrial biogenesis and energy production with many diverse cellular functions.