Journal ArticleDOI
Effects of Intermittent Fasting on Health, Aging, and Disease
Rafael de Cabo,Mark P. Mattson +1 more
TLDR
Effects of Intermittent Fasting on Health and Aging evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base fasting.Abstract:
Effects of Intermittent Fasting on Health and Aging Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base...read more
Citations
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Journal ArticleDOI
Ayurvedic formulations amalaki rasayana and rasa sindoor improve age-associated memory deficits in mice by modulating dendritic spine densities
TL;DR: In this article , Amalaki aasayana (AR, 1025 mg/kg per day) and rasa sindoor (RS, 41 mg/ kg per day), mixed in a gelatin-based jelly for six months, were fed to two-month-old mice.
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Aerobic Exercise in the Fasted State: the Effects on Energy Metabolism in Healthy Adults
TL;DR: A review of the relevant literature since 2005 relating to the healthy adult population was undertaken, resulting in the critical appraisal of 21 articles as discussed by the authors , showing preferential reliance on fat oxidation, enhanced glucose metabolism and mitochondrial activity, all of which is coordinated through pathways regulated by nuclear hormone receptors.
Journal ArticleDOI
"Effect of time-restricted feeding on high-fat diet-induced metabolic dysfunction in Drosophila melanogaster".
TL;DR: In this article , the effect of time-restricted feeding on metabolic and molecular markers was evaluated in flies with metabolic damage and chronodisruption in a Drosophila melanogaster, and the results showed that TRF could help to ameliorate metabolic and chronobiologic damage induced by a high-fat diet.
Journal ArticleDOI
The Role of Systemic Filtrating Organs in Aging and Their Potential in Rejuvenation Strategies
TL;DR: The kidney as a filtration organ is clearly implicated, for the first time, with the aging phenomenon, necessitating a re-evaluation of current rejuvenation studies to untangle the extent of its involvement and its possible role as a potentiator in aging.
Journal ArticleDOI
Guidance for Physicians on the Yom Kippur Fast
TL;DR: In this article , the authors present the Talmudic laws on fasting on Yom Kippur, interviews with 11 Georgetown students and faculty on the subjective importance of the fast, and a review of medical literature regarding contraindications to fasting.
References
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Journal ArticleDOI
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Ricki J. Colman,Rozalyn M. Anderson,Sterling C. Johnson,Erik K. Kastman,Kristopher J. Kosmatka,T. Mark Beasley,David B. Allison,Christina Cruzen,Heather A. Simmons,Joseph W. Kemnitz,Richard Weindruch +10 more
TL;DR: Findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research demonstrate that CR slows aging in a primate species.
Journal ArticleDOI
Risk of dementia in diabetes mellitus: a systematic review
TL;DR: The findings of mechanistic studies suggest that vascular disease and alterations in glucose, insulin, and amyloid metabolism underlie the pathophysiology of dementia, but which of these mechanisms are clinically relevant is unclear.
Journal ArticleDOI
Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet
Megumi Hatori,Christopher Vollmers,Amir Zarrinpar,Amir Zarrinpar,Luciano DiTacchio,Eric A. Bushong,Shubhroz Gill,Mathias Leblanc,Amandine Chaix,Matthew S. Joens,James A. J. Fitzpatrick,Mark H. Ellisman,Satchidananda Panda +12 more
TL;DR: Mice under tRF consume equivalent calories from HFD as those with ad lib access yet are protected against obesity, hyperinsulinemia, hepatic steatosis, and inflammation and have improved motor coordination.
Journal ArticleDOI
Starvation in man.
TL;DR: In this article, it was shown that decreased levels of active T3 may play a role by sparing otherwise obligated calories by decreasing metabolic needs, but this can be nullified by amino acid or protein supplementation.
Journal ArticleDOI
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network.
TL;DR: The results point to a central role for the PGC-1 family in integrating mitochondrial biogenesis and energy production with many diverse cellular functions.