Journal ArticleDOI
Effects of Intermittent Fasting on Health, Aging, and Disease
Rafael de Cabo,Mark P. Mattson +1 more
TLDR
Effects of Intermittent Fasting on Health and Aging evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base fasting.Abstract:
Effects of Intermittent Fasting on Health and Aging Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base...read more
Citations
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Journal ArticleDOI
Autophagy in healthy aging and disease
Yahyah Aman,Yahyah Aman,Tomas Schmauck-Medina,Malene Hansen,Richard I. Morimoto,Anna Katharina Simon,Ivana Bjedov,Konstantinos Palikaras,Anne Simonsen,Anne Simonsen,Terje Johansen,Nektarios Tavernarakis,Nektarios Tavernarakis,David C. Rubinsztein,Linda Partridge,Linda Partridge,Guido Kroemer,John Labbadia,Evandro Fei Fang +18 more
TL;DR: A recent review as discussed by the authors examines several emerging features of autophagy and postulates how they may be linked to aging as well as to the development and progression of disease, and discusses current preclinical evidence arguing for the use of auto-ophagy modulators as suppressors of age-related pathologies such as neurodegenerative diseases.
Journal ArticleDOI
Effects of 4- and 6-h Time-Restricted Feeding on Weight and Cardiometabolic Health: A Randomized Controlled Trial in Adults with Obesity.
Sofia Cienfuegos,Kelsey Gabel,Faiza Kalam,Mark Ezpeleta,Eric Wiseman,Vasiliki Pavlou,Shuhao Lin,Manoela Lima Oliveira,Krista A. Varady +8 more
TL;DR: It is suggested that 4- and 6-h TRF induce mild reductions in body weight over 8 weeks and show promise as interventions for weight loss and may also improve some aspects of cardiometabolic health.
Journal ArticleDOI
NAFLD and cardiovascular diseases: a clinical review.
Philipp Kasper,Anna Martin,Sonja Lang,Fabian Kütting,Tobias Goeser,Münevver Demir,Hans-Michael Steffen +6 more
TL;DR: The underlying pathophysiological mechanisms linking NAFLD and CVD are described, the role ofNAFLD as a metabolic dysfunction associated cardiovascular risk factor is discussed, and common cardiovascular manifestations in NAFLd patients are focused on.
Journal ArticleDOI
A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks
Evandro Fei Fang,Chenglong Xie,Chenglong Xie,Joseph Adam Schenkel,Chenkai Wu,Qian Long,Honghua Cui,Yahyah Aman,Johannes Frank,Jing Liao,Huachun Zou,Huachun Zou,Ninie Y. Wang,Jing Wu,Xiaoting Liu,Li Tao,Fang Yuan,Zhangming Niu,Guang Yang,Jiangshui Hong,Qian Wang,Guobing Chen,Jun Li,Hou-Zao Chen,Lin Kang,Huanxing Su,Brian C. Gilmour,Xinqiang Zhu,Hong Jiang,Na He,Tao Jun,Sean Xiao Leng,Tanjun Tong,Jean Woo +33 more
TL;DR: Collectively, synergies across disciplines on policies, geriatric care, drug development, personal awareness, the use of big data, machine learning and personalized medicine will transform China into a country that enables the most for its elderly, maximizing and celebrating their longevity in the coming decades.
Journal ArticleDOI
Dietary Strategies for Metabolic Syndrome: A Comprehensive Review
Sara Castro-Barquero,Sara Castro-Barquero,Ana María Ruiz-León,Ana María Ruiz-León,Maria Sierra-Pérez,Ramon Estruch,Ramon Estruch,Rosa Casas,Rosa Casas +8 more
TL;DR: On comparing low-fat and restricted diets, the scientific evidence supports the use of the Mediterranean Dietary Approaches to Stop Hypertension (DASH) diet intervention as the new paradigm for metabolic syndrome prevention and treatment.
References
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Journal ArticleDOI
Time-Restricted Feeding Is a Preventative and Therapeutic Intervention against Diverse Nutritional Challenges
TL;DR: It is shown that TRF attenuated metabolic diseases arising from a variety of obesogenic diets, and that benefits were proportional to the fasting duration, and protective effects were maintained even when TRF was temporarily interrupted by ad libitum access to food during weekends.
Journal ArticleDOI
Circadian physiology of metabolism.
TL;DR: These findings highlight an integrative role of circadian rhythms in physiology and offer a new perspective for treating chronic diseases in which metabolic disruption is a hallmark.
Journal ArticleDOI
Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake
R. Michael Anson,Zhihong Guo,Rafael de Cabo,Titilola Iyun,Michelle Rios,Adrienne Hagepanos,Donald K. Ingram,Mark A. Lane,Mark P. Mattson +8 more
TL;DR: In conclusion, intermittent fasting resulted in beneficial effects that met or exceeded those of caloric restriction including reduced serum glucose and insulin levels and increased resistance of neurons in the brain to excitotoxic stress in these mice.
Journal ArticleDOI
The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women
Michelle Harvie,Mary Pegington,Mark P. Mattson,Jan Frystyk,Bernice Dillon,Gareth Evans,Jack Cuzick,Susan A. Jebb,Bronwen Martin,Roy G. Cutler,Tae G. Son,Stuart Maudsley,Olga D. Carlson,Josephine M. Egan,Allan Flyvbjerg,Anthony Howell +15 more
TL;DR: IER is as effective as CER with regard to weight loss, insulin sensitivity and other health biomarkers, and may be offered as an alternative equivalent to CER for weight loss and reducing disease risk.
Journal ArticleDOI
Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States.
TL;DR: An overview of the cellular and molecular biology of brain aging, how those processes interface with disease-specific neurodegenerative pathways, and how metabolic states influence brain health is provided.