Journal ArticleDOI
Effects of Intermittent Fasting on Health, Aging, and Disease
Rafael de Cabo,Mark P. Mattson +1 more
TLDR
Effects of Intermittent Fasting on Health and Aging evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base fasting.Abstract:
Effects of Intermittent Fasting on Health and Aging Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base...read more
Citations
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Autophagy in healthy aging and disease
Yahyah Aman,Yahyah Aman,Tomas Schmauck-Medina,Malene Hansen,Richard I. Morimoto,Anna Katharina Simon,Ivana Bjedov,Konstantinos Palikaras,Anne Simonsen,Anne Simonsen,Terje Johansen,Nektarios Tavernarakis,Nektarios Tavernarakis,David C. Rubinsztein,Linda Partridge,Linda Partridge,Guido Kroemer,John Labbadia,Evandro Fei Fang +18 more
TL;DR: A recent review as discussed by the authors examines several emerging features of autophagy and postulates how they may be linked to aging as well as to the development and progression of disease, and discusses current preclinical evidence arguing for the use of auto-ophagy modulators as suppressors of age-related pathologies such as neurodegenerative diseases.
Journal ArticleDOI
Effects of 4- and 6-h Time-Restricted Feeding on Weight and Cardiometabolic Health: A Randomized Controlled Trial in Adults with Obesity.
Sofia Cienfuegos,Kelsey Gabel,Faiza Kalam,Mark Ezpeleta,Eric Wiseman,Vasiliki Pavlou,Shuhao Lin,Manoela Lima Oliveira,Krista A. Varady +8 more
TL;DR: It is suggested that 4- and 6-h TRF induce mild reductions in body weight over 8 weeks and show promise as interventions for weight loss and may also improve some aspects of cardiometabolic health.
Journal ArticleDOI
NAFLD and cardiovascular diseases: a clinical review.
Philipp Kasper,Anna Martin,Sonja Lang,Fabian Kütting,Tobias Goeser,Münevver Demir,Hans-Michael Steffen +6 more
TL;DR: The underlying pathophysiological mechanisms linking NAFLD and CVD are described, the role ofNAFLD as a metabolic dysfunction associated cardiovascular risk factor is discussed, and common cardiovascular manifestations in NAFLd patients are focused on.
Journal ArticleDOI
A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks
Evandro Fei Fang,Chenglong Xie,Chenglong Xie,Joseph Adam Schenkel,Chenkai Wu,Qian Long,Honghua Cui,Yahyah Aman,Johannes Frank,Jing Liao,Huachun Zou,Huachun Zou,Ninie Y. Wang,Jing Wu,Xiaoting Liu,Li Tao,Fang Yuan,Zhangming Niu,Guang Yang,Jiangshui Hong,Qian Wang,Guobing Chen,Jun Li,Hou-Zao Chen,Lin Kang,Huanxing Su,Brian C. Gilmour,Xinqiang Zhu,Hong Jiang,Na He,Tao Jun,Sean Xiao Leng,Tanjun Tong,Jean Woo +33 more
TL;DR: Collectively, synergies across disciplines on policies, geriatric care, drug development, personal awareness, the use of big data, machine learning and personalized medicine will transform China into a country that enables the most for its elderly, maximizing and celebrating their longevity in the coming decades.
Journal ArticleDOI
Dietary Strategies for Metabolic Syndrome: A Comprehensive Review
Sara Castro-Barquero,Sara Castro-Barquero,Ana María Ruiz-León,Ana María Ruiz-León,Maria Sierra-Pérez,Ramon Estruch,Ramon Estruch,Rosa Casas,Rosa Casas +8 more
TL;DR: On comparing low-fat and restricted diets, the scientific evidence supports the use of the Mediterranean Dietary Approaches to Stop Hypertension (DASH) diet intervention as the new paradigm for metabolic syndrome prevention and treatment.
References
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Cancer metabolism: a therapeutic perspective
Ubaldo E. Martinez-Outschoorn,Maria Peiris-Pagès,Richard G. Pestell,Federica Sotgia,Federica Sotgia,Michael P. Lisanti +5 more
TL;DR: How cancer cells reprogramme their metabolism and that of other cells within the tumour microenvironment in order to survive and propagate, thus driving disease progression is discussed; in particular, potential metabolic vulnerabilities that might be targeted therapeutically are highlighted.
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Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
Julie A. Mattison,George S. Roth,T. Mark Beasley,Edward M. Tilmont,April M. Handy,April M. Handy,Richard Herbert,Dan L. Longo,David B. Allison,Jennifer E. Young,Mark Bryant,Dennis Barnard,Walter F. Ward,Wenbo Qi,Donald K. Ingram,Rafael de Cabo +15 more
TL;DR: A separation between health effects, morbidity and mortality, and similar to what has been shown in rodents, study design, husbandry and diet composition may strongly affect the life-prolonging effect of CR in a long-lived nonhuman primate is suggested.
Journal ArticleDOI
Fasting: Molecular Mechanisms and Clinical Applications
TL;DR: In rodents intermittent or periodic fasting protects against diabetes, cancers, heart disease, and neurodegeneration, while in humans it helps reduce obesity, hypertension, asthma, and rheumatoid arthritis.
Journal ArticleDOI
Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice
TL;DR: It is suggested that BDNF plays an important role in the regulation of the basal level of neurogenesis in dentate gyrus of adult mice, and that by promoting the survival of newly generated neurons BDNF contributes to the enhancement of Neurogenesis induced by DR.
Journal ArticleDOI
Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial.
Leonie K. Heilbronn,Lilian de Jonge,Madlyn I. Frisard,James P. DeLany,D. Enette Larson-Meyer,Jennifer Rood,Tuong Nguyen,Corby K. Martin,Julia Volaufova,Marlene M. Most,Frank L. Greenway,Steven R. Smith,Walter A. Deutsch,Donald A. Williamson,Eric Ravussin +14 more
TL;DR: The findings suggest that 2 biomarkers of longevity (fasting insulin level and body temperature) are decreased by prolonged calorie restriction in humans and support the theory that metabolic rate is reduced beyond the level expected from reduced metabolic body mass.