Journal ArticleDOI
Effects of Intermittent Fasting on Health, Aging, and Disease
Rafael de Cabo,Mark P. Mattson +1 more
TLDR
Effects of Intermittent Fasting on Health and Aging evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base fasting.Abstract:
Effects of Intermittent Fasting on Health and Aging Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base...read more
Citations
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Journal ArticleDOI
Anticancer action of caloric restrictions via microbiota
Laurence Zitvogel,Guido Kroemer +1 more
Journal ArticleDOI
Fasting Intervention for Children With Unilateral Renal Tumors to Reduce Toxicity
C. A. J. Oudmaijer,Winnie M.C. van den Boogaard,D. Komninos,Emma J. Verwaaijen,Hanneke M van Santen,Marc R. Lilien,Jan H.J. Hoeijmakers,Marc H. W. A. Wijnen,Marry M. van den Heuvel-Eibrink,Wilbert P. Vermeij +9 more
TL;DR: The main study objective is to investigate the potential decrease in occurrence of AKI due to short-term fasting, and the effect of STF on renal function recovery after renal tumor surgery by conducting a single-center, prospective, randomized, non-blinded, intervention study.
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Personalized medicine: will it work for decreasing age-related morbidities?
TL;DR: In this article , the potential of personalized medicine for creating individualized treatments for preventing or reversing the biological mechanisms of aging is discussed, and the potential for personalized medicine to be used for personalized treatments based on individual patient characteristics is discussed.
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Dietary interventions and precision nutrition in cancer therapy.
TL;DR: In this paper , the authors provide a complete overview of the contemporary landscape of nutritional interventions and precision nutrition as cancer therapeutics, and offer a perspective on the steps necessary to establish nutritional interventions as a standard line of treatment.
Posted ContentDOI
Mixed Models Quantify Annual Volume Change; Linear Regression Determines Thalamic Volume as the Best Subcortical Structure Volume Predictor in Alzheimer’s Disease and Aging
TL;DR: In this paper , the authors quantified annual structure volume change from baseline to 24-months for the hippocampus, putamen, cerebellum, lateral ventricles and thalamus.
References
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Journal ArticleDOI
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Ricki J. Colman,Rozalyn M. Anderson,Sterling C. Johnson,Erik K. Kastman,Kristopher J. Kosmatka,T. Mark Beasley,David B. Allison,Christina Cruzen,Heather A. Simmons,Joseph W. Kemnitz,Richard Weindruch +10 more
TL;DR: Findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research demonstrate that CR slows aging in a primate species.
Journal ArticleDOI
Risk of dementia in diabetes mellitus: a systematic review
TL;DR: The findings of mechanistic studies suggest that vascular disease and alterations in glucose, insulin, and amyloid metabolism underlie the pathophysiology of dementia, but which of these mechanisms are clinically relevant is unclear.
Journal ArticleDOI
Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet
Megumi Hatori,Christopher Vollmers,Amir Zarrinpar,Amir Zarrinpar,Luciano DiTacchio,Eric A. Bushong,Shubhroz Gill,Mathias Leblanc,Amandine Chaix,Matthew S. Joens,James A. J. Fitzpatrick,Mark H. Ellisman,Satchidananda Panda +12 more
TL;DR: Mice under tRF consume equivalent calories from HFD as those with ad lib access yet are protected against obesity, hyperinsulinemia, hepatic steatosis, and inflammation and have improved motor coordination.
Journal ArticleDOI
Starvation in man.
TL;DR: In this article, it was shown that decreased levels of active T3 may play a role by sparing otherwise obligated calories by decreasing metabolic needs, but this can be nullified by amino acid or protein supplementation.
Journal ArticleDOI
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network.
TL;DR: The results point to a central role for the PGC-1 family in integrating mitochondrial biogenesis and energy production with many diverse cellular functions.