Journal ArticleDOI
Effects of Intermittent Fasting on Health, Aging, and Disease
Rafael de Cabo,Mark P. Mattson +1 more
TLDR
Effects of Intermittent Fasting on Health and Aging evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base fasting.Abstract:
Effects of Intermittent Fasting on Health and Aging Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base...read more
Citations
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Journal ArticleDOI
Time-Restricted Eating and Metabolic Syndrome: Current Status and Future Perspectives.
TL;DR: Time-restricted eating (TRE) as discussed by the authors is a promising strategy for patients with metabolic syndrome (MetS) which aims at restoring robust circadian rhythms through modification of timing and duration of daily eating.
Journal ArticleDOI
The dark side of the spoon - glucose, ketones and COVID-19: a possible role for ketogenic diet?
TL;DR: The importance of KDs for a rapid reduction of several critical risk factors for COVID-19, such as obesity, type 2 diabetes and hypertension, based on the known effects of ketone bodies on inflammation, immunity, metabolic profile and cardiovascular function is discussed.
Journal ArticleDOI
Does four-week consecutive, dawn-to-sunset intermittent fasting during Ramadan affect cardiometabolic risk factors in healthy adults? A systematic review, meta-analysis, and meta-regression.
Haitham Jahrami,Mo'ez Al-Islam E. Faris,Abdulrahman Ismaeel Janahi,Mohamed I. Janahi,Dana Abdelrahim,Mohamed Madkour,Mai S. Sater,Adla B Hassan,Ahmed S. BaHammam +8 more
TL;DR: In this paper, the effect of diurnal intermittent fasting (RDIF) on cardiovascular risk factors (CMRF) in healthy adults was evaluated using sub-group meta-regression.
Journal ArticleDOI
A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice
Michael A. Petr,Michael A. Petr,Irene Alfaras,Melissa Krawcyzk,Woei-Nan Bair,Woei-Nan Bair,Sarah J. Mitchell,Christopher H. Morrell,Stephanie A. Studenski,Stephanie A. Studenski,Nathan L. Price,Kenneth W. Fishbein,Richard G. Spencer,Morten Scheibye-Knudsen,Edward G. Lakatta,Luigi Ferrucci,Miguel A. Aon,Michel Bernier,Rafael de Cabo +18 more
TL;DR: In this paper, the authors conducted physiologic and functional tests cross-sectionally throughout the entire lifespan of male C57BL/6N mice and performed metabolomics analyses in serum, brain, liver, heart, and skeletal muscle to identify signatures associated with frailty and age-dependent functional decline.
Journal ArticleDOI
Time-Restricted Feeding Reduces the Detrimental Effects of a High-Fat Diet, Possibly by Modulating the Circadian Rhythm of Hepatic Lipid Metabolism and Gut Microbiota.
TL;DR: Mice fed a time-restricted high-fat diet showed distinct circadian rhythms of hepatic expression of SIRT1, SREBP, and PPARα compared with mice fed a normal diet ad libitum, as well as the circadian rhythm of the abundance of Bacteroidetes and Firmicutes.
References
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Journal ArticleDOI
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Ricki J. Colman,Rozalyn M. Anderson,Sterling C. Johnson,Erik K. Kastman,Kristopher J. Kosmatka,T. Mark Beasley,David B. Allison,Christina Cruzen,Heather A. Simmons,Joseph W. Kemnitz,Richard Weindruch +10 more
TL;DR: Findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research demonstrate that CR slows aging in a primate species.
Journal ArticleDOI
Risk of dementia in diabetes mellitus: a systematic review
TL;DR: The findings of mechanistic studies suggest that vascular disease and alterations in glucose, insulin, and amyloid metabolism underlie the pathophysiology of dementia, but which of these mechanisms are clinically relevant is unclear.
Journal ArticleDOI
Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet
Megumi Hatori,Christopher Vollmers,Amir Zarrinpar,Amir Zarrinpar,Luciano DiTacchio,Eric A. Bushong,Shubhroz Gill,Mathias Leblanc,Amandine Chaix,Matthew S. Joens,James A. J. Fitzpatrick,Mark H. Ellisman,Satchidananda Panda +12 more
TL;DR: Mice under tRF consume equivalent calories from HFD as those with ad lib access yet are protected against obesity, hyperinsulinemia, hepatic steatosis, and inflammation and have improved motor coordination.
Journal ArticleDOI
Starvation in man.
TL;DR: In this article, it was shown that decreased levels of active T3 may play a role by sparing otherwise obligated calories by decreasing metabolic needs, but this can be nullified by amino acid or protein supplementation.
Journal ArticleDOI
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network.
TL;DR: The results point to a central role for the PGC-1 family in integrating mitochondrial biogenesis and energy production with many diverse cellular functions.