Journal ArticleDOI
Effects of Intermittent Fasting on Health, Aging, and Disease
Rafael de Cabo,Mark P. Mattson +1 more
TLDR
Effects of Intermittent Fasting on Health and Aging evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base fasting.Abstract:
Effects of Intermittent Fasting on Health and Aging Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base...read more
Citations
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Autophagy in healthy aging and disease
Yahyah Aman,Yahyah Aman,Tomas Schmauck-Medina,Malene Hansen,Richard I. Morimoto,Anna Katharina Simon,Ivana Bjedov,Konstantinos Palikaras,Anne Simonsen,Anne Simonsen,Terje Johansen,Nektarios Tavernarakis,Nektarios Tavernarakis,David C. Rubinsztein,Linda Partridge,Linda Partridge,Guido Kroemer,John Labbadia,Evandro Fei Fang +18 more
TL;DR: A recent review as discussed by the authors examines several emerging features of autophagy and postulates how they may be linked to aging as well as to the development and progression of disease, and discusses current preclinical evidence arguing for the use of auto-ophagy modulators as suppressors of age-related pathologies such as neurodegenerative diseases.
Journal ArticleDOI
Effects of 4- and 6-h Time-Restricted Feeding on Weight and Cardiometabolic Health: A Randomized Controlled Trial in Adults with Obesity.
Sofia Cienfuegos,Kelsey Gabel,Faiza Kalam,Mark Ezpeleta,Eric Wiseman,Vasiliki Pavlou,Shuhao Lin,Manoela Lima Oliveira,Krista A. Varady +8 more
TL;DR: It is suggested that 4- and 6-h TRF induce mild reductions in body weight over 8 weeks and show promise as interventions for weight loss and may also improve some aspects of cardiometabolic health.
Journal ArticleDOI
NAFLD and cardiovascular diseases: a clinical review.
Philipp Kasper,Anna Martin,Sonja Lang,Fabian Kütting,Tobias Goeser,Münevver Demir,Hans-Michael Steffen +6 more
TL;DR: The underlying pathophysiological mechanisms linking NAFLD and CVD are described, the role ofNAFLD as a metabolic dysfunction associated cardiovascular risk factor is discussed, and common cardiovascular manifestations in NAFLd patients are focused on.
Journal ArticleDOI
A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks
Evandro Fei Fang,Chenglong Xie,Chenglong Xie,Joseph Adam Schenkel,Chenkai Wu,Qian Long,Honghua Cui,Yahyah Aman,Johannes Frank,Jing Liao,Huachun Zou,Huachun Zou,Ninie Y. Wang,Jing Wu,Xiaoting Liu,Li Tao,Fang Yuan,Zhangming Niu,Guang Yang,Jiangshui Hong,Qian Wang,Guobing Chen,Jun Li,Hou-Zao Chen,Lin Kang,Huanxing Su,Brian C. Gilmour,Xinqiang Zhu,Hong Jiang,Na He,Tao Jun,Sean Xiao Leng,Tanjun Tong,Jean Woo +33 more
TL;DR: Collectively, synergies across disciplines on policies, geriatric care, drug development, personal awareness, the use of big data, machine learning and personalized medicine will transform China into a country that enables the most for its elderly, maximizing and celebrating their longevity in the coming decades.
Journal ArticleDOI
Dietary Strategies for Metabolic Syndrome: A Comprehensive Review
Sara Castro-Barquero,Sara Castro-Barquero,Ana María Ruiz-León,Ana María Ruiz-León,Maria Sierra-Pérez,Ramon Estruch,Ramon Estruch,Rosa Casas,Rosa Casas +8 more
TL;DR: On comparing low-fat and restricted diets, the scientific evidence supports the use of the Mediterranean Dietary Approaches to Stop Hypertension (DASH) diet intervention as the new paradigm for metabolic syndrome prevention and treatment.
References
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Journal ArticleDOI
Dietary restriction in rats and mice: A meta-analysis and review of the evidence for genotype-dependent effects on lifespan
TL;DR: Findings suggest that the set of genetic backgrounds studied in rodent DR experiments should be diversified, which will broaden the scope of genotypes studied in aging research, but may also be critical for translation of findings from rodents to historically outbred and genetically heterogeneous primate species.
Journal ArticleDOI
Preoperative very low-calorie diet and operative outcome after laparoscopic gastric bypass: a randomized multicenter study.
Yves Van Nieuwenhove,Zilvinas Dambrauskas,Álvaro Campillo-Soto,François M. H. van Dielen,René M. Wiezer,Ignace M. C. Janssen,Michael Kramer,Anders Thorell +7 more
TL;DR: The finding of reduced postoperative complication rates suggests that a 14-day very low-calorie diet (VLCD) regimen should be recommended before bariatric surgery.
Journal ArticleDOI
Caloric Restriction Increases Learning Consolidation and Facilitates Synaptic Plasticity through Mechanisms Dependent on NR2B Subunits of the NMDA Receptor
Ángela Fontán-Lozano,José Luis Sáez-Cassanelli,Mari Carmen Inda,Mercedes de los Santos-Arteaga,Sergio Antonio Sierra-Domínguez,Guillermo López-Lluch,José M. Delgado-García,Angel M. Carrión +7 more
TL;DR: The effects of maintaining mature mice on a long-term intermittent fasting diet (L-IFD) are found to enhance learning and consolidation processes and to provide a molecular and cellular mechanism by which L-IFd may enhance cognition, ameliorating some aging-associated cognitive deficits.
Journal ArticleDOI
Design and Conduct of the CALERIE Study: Comprehensive Assessment of the Long-term Effects of Reducing Intake of Energy
James Rochon,Connie W. Bales,Connie W. Bales,Eric Ravussin,Leanne M. Redman,John O. Holloszy,Susan B. Racette,Susan B. Roberts,Sai Krupa Das,Sergei Romashkan,Katherine M Galan,Evan C. Hadley,William E. Kraus +12 more
TL;DR: The designs and implementation of the CALERIE research program, the first systematic investigation of CR in nonobese human beings, provide insight into the detrimental changes associated with the human aging process and how CR mitigates these effects.
Journal ArticleDOI
Effect of Calorie Restriction on Mood, Quality of Life, Sleep, and Sexual Function in Healthy Nonobese Adults: The CALERIE 2 Randomized Clinical Trial
Corby K. Martin,Manju Bhapkar,Anastassios G. Pittas,Carl F. Pieper,Sai Krupa Das,Donald A. Williamson,Tammy Scott,Leanne M. Redman,Richard I. Stein,Cheryl H. Gilhooly,Tiffany M. Stewart,Lisa M. Robinson,Susan B. Roberts +12 more
TL;DR: A multisite randomized clinical trial to test the effect of CR on mood, quality of life, sleep, and sexual function in healthy nonobese adults found that greater percent weight loss in the CR group at month 24 was associated with increased vigor and less mood disturbance.