Journal ArticleDOI
Effects of Intermittent Fasting on Health, Aging, and Disease
Rafael de Cabo,Mark P. Mattson +1 more
TLDR
Effects of Intermittent Fasting on Health and Aging evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base fasting.Abstract:
Effects of Intermittent Fasting on Health and Aging Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base...read more
Citations
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Posted ContentDOI
A Pilot Study on the Effects of Medically Supervised, Water-Only Fasting and Refeeding on Cardiometabolic Risk
Eugene L. Scharf,Patricia Kolbe,Su-Yeon Hwang,Natasha Thompson,Mara Gilbert,Faye Alexandrakis,Matthieu Bonjour,Evelyn Zeiler,Toshia R. Myers +8 more
TL;DR: The Fasting for Brain and Heart Health Study as mentioned in this paperocusing on the effects of medically supervised, water-only fasting followed by an exclusively whole-plant-food refeeding diet on accepted measures of cardiovascular risk and metabolic health.
Journal ArticleDOI
Older American Women May Especially Benefit from Distributing and Consuming Protein for Decreasing Odds of Functional Limitations
A. Houfek,Julie Garden-Robinson,Elizabeth Hilliard,Yeong Rhee,Sherri Stastny,Martha A. Belury,PM Cawthon,Ryan McGrath +7 more
Journal ArticleDOI
Every-other-day fasting reduces glycolytic capability in the skeletal muscle of young mice
Oksana M. Sorochynska,Oksana V. Kuzniak,Maria M. Bayliak,Yulia V. Vasylyk,Kenneth B. Storey,Volodymyr I. Lushchak +5 more
TL;DR: Comparing the capability of skeletal hind limb muscle of one month old mice to catabolize glucose via glycolytic and pentose phosphate pathways under conditions of eating to satiation (ad libitum, AL feeding) versus limited access to food (dietary restriction in the form of every-other-day fasting, EODF) shows that muscles of EodF young mice possess a lower capacity to carry out gly colysis than those from AL fed counterparts.
Journal ArticleDOI
Sex differences in pharmacological interventions and their effects on lifespan and healthspan outcomes: a systematic review
TL;DR: In this article , the authors performed a systematic review of the literature according to the PRISMA guidelines and found that twenty-two out of sixty-four compounds tested were able to prolong both lifespan and healthspan measures.
References
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Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Ricki J. Colman,Rozalyn M. Anderson,Sterling C. Johnson,Erik K. Kastman,Kristopher J. Kosmatka,T. Mark Beasley,David B. Allison,Christina Cruzen,Heather A. Simmons,Joseph W. Kemnitz,Richard Weindruch +10 more
TL;DR: Findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research demonstrate that CR slows aging in a primate species.
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Risk of dementia in diabetes mellitus: a systematic review
TL;DR: The findings of mechanistic studies suggest that vascular disease and alterations in glucose, insulin, and amyloid metabolism underlie the pathophysiology of dementia, but which of these mechanisms are clinically relevant is unclear.
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Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet
Megumi Hatori,Christopher Vollmers,Amir Zarrinpar,Amir Zarrinpar,Luciano DiTacchio,Eric A. Bushong,Shubhroz Gill,Mathias Leblanc,Amandine Chaix,Matthew S. Joens,James A. J. Fitzpatrick,Mark H. Ellisman,Satchidananda Panda +12 more
TL;DR: Mice under tRF consume equivalent calories from HFD as those with ad lib access yet are protected against obesity, hyperinsulinemia, hepatic steatosis, and inflammation and have improved motor coordination.
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Starvation in man.
TL;DR: In this article, it was shown that decreased levels of active T3 may play a role by sparing otherwise obligated calories by decreasing metabolic needs, but this can be nullified by amino acid or protein supplementation.
Journal ArticleDOI
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network.
TL;DR: The results point to a central role for the PGC-1 family in integrating mitochondrial biogenesis and energy production with many diverse cellular functions.