Journal ArticleDOI
Exosomes as nanocarriers for immunotherapy of cancer and inflammatory diseases.
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TLDR
This review focuses on the application of exosomes as nanocarriers and immunological agents for cancer and autoimmune immunotherapy, and shows APC-derived exosome demonstrate effective therapeutic efficacy for the treatment of cancer and experimental autoimmune diseases.About:
This article is published in Clinical Immunology.The article was published on 2015-09-01. It has received 144 citations till now. The article focuses on the topics: Microvesicles & Immunotherapy.read more
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Diverse Applications of Nanomedicine
Beatriz Pelaz,Christoph Alexiou,Ramon A. Alvarez-Puebla,Frauke Alves,Frauke Alves,Anne M. Andrews,Sumaira Ashraf,Lajos P. Balogh,Laura Ballerini,Alessandra Bestetti,Cornelia Brendel,Susanna Bosi,Mónica Carril,Warren C. W. Chan,Chunying Chen,Xiaodong Chen,Xiaoyuan Chen,Zhen Cheng,Daxiang Cui,Jianzhong Du,Christian Dullin,Alberto Escudero,Alberto Escudero,Neus Feliu,Mingyuan Gao,Michael D. George,Yury Gogotsi,Arnold Grünweller,Zhongwei Gu,Naomi J. Halas,Norbert Hampp,Roland K. Hartmann,Mark C. Hersam,Patrick Hunziker,Ji Jian,Xingyu Jiang,Philipp Jungebluth,Pranav Kadhiresan,Kazunori Kataoka,Ali Khademhosseini,Jindřich Kopeček,Nicholas A. Kotov,Harald F. Krug,Dong Soo Lee,Claus-Michael Lehr,Kam W. Leong,Xing-Jie Liang,Mei Ling Lim,Luis M. Liz-Marzán,Xiaowei Ma,Paolo Macchiarini,Huan Meng,Helmuth Möhwald,Paul Mulvaney,Andre E. Nel,Shuming Nie,Peter Nordlander,Teruo Okano,Jose Oliveira,Tai Hyun Park,Reginald M. Penner,Maurizio Prato,Maurizio Prato,Víctor F. Puntes,Vincent M. Rotello,Amila Samarakoon,Raymond E. Schaak,Youqing Shen,Sebastian Sjöqvist,Andre G. Skirtach,Andre G. Skirtach,Mahmoud Soliman,Molly M. Stevens,Hsing-Wen Sung,Ben Zhong Tang,Rainer Tietze,Buddhisha Udugama,J. Scott VanEpps,Tanja Weil,Tanja Weil,Paul S. Weiss,Itamar Willner,Yuzhou Wu,Yuzhou Wu,Lily Yang,Zhao Yue,Qian Zhang,Qiang Zhang,Xian-En Zhang,Yuliang Zhao,Xin Zhou,Wolfgang J. Parak +91 more
TL;DR: An overview of recent developments in nanomedicine is provided and the current challenges and upcoming opportunities for the field are highlighted and translation to the clinic is highlighted.
Journal ArticleDOI
Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges
TL;DR: The origin and structure of exosomes as well as their biological functions are outlined and specific applications of exOSomes as drug delivery systems in pharmaceutical drug development are focused on.
Journal ArticleDOI
Exosomes: From Garbage Bins to Promising Therapeutic Targets
Mohammed H. Rashed,Mohammed H. Rashed,Emine Bayraktar,Emine Bayraktar,Gouda K. Helal,Mohamed F. Abd-Ellah,Paola Amero,Arturo Chavez-Reyes,Cristian Rodriguez-Aguayo +8 more
TL;DR: The aim of this review is to reveal the emerging roles of exosomes in normal and pathological conditions and describe the controversial biological role ofExosomes, as it is now understood, in carcinogenesis.
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Exosome Biochemistry and Advanced Nanotechnology for Next-Generation Theranostic Platforms.
Bowen Yang,Yu Chen,Jianlin Shi +2 more
TL;DR: It is highly expected that the better and clearer elucidation of the fundamental principles for advanced nanotechnology in constructing exosome‐based theranostic nanoplatforms, as well as integrating the intrinsic advantages of exosomes as endogenous cell‐derived nanocarriers with the advanced design methodology of traditional nanomedicine, will help to unlock the innate powers ofExosomes for the establishment of next‐generation theranostics.
Journal ArticleDOI
Pancreatic cancer-targeting exosomes for enhancing immunotherapy and reprogramming tumor microenvironment.
Wenxi Zhou,Yu Zhou,Xinli Chen,Tingting Ning,Hongyi Chen,Qin Guo,Yiwen Zhang,Peixin Liu,Yujie Zhang,Chao Li,Yongchao Chu,Tao Sun,Chen Jiang +12 more
TL;DR: An exosome-based dual delivery biosystem for enhancing PDAC immunotherapy as well as reversing tumor immunosuppression of M2-like tumor associated macrophages (M2-TAMs) upon disruption of galectin-9/dectin 1 axis is demonstrated.
References
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Journal ArticleDOI
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
TL;DR: It is shown that exosomes contain both mRNA and microRNA, which can be delivered to another cell, and can be functional in this new location, and it is proposed that this RNA is called “exosomal shuttle RNA” (esRNA).
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Immunity, Inflammation, and Cancer
TL;DR: The principal mechanisms that govern the effects of inflammation and immunity on tumor development are outlined and attractive new targets for cancer therapy and prevention are discussed.
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Exosomes: composition, biogenesis and function
TL;DR: The physical properties that define exosomes as a specific population of secreted vesicles are described, their biological effects, particularly on the immune system, are summarized, and the potential roles that secretedvesicles could have as intercellular messengers are discussed.
Journal ArticleDOI
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
TL;DR: It is shown that exosomes—endogenous nano-vesicles that transport RNAs and proteins—can deliver short interfering (si)RNA to the brain in mice, and the therapeutic potential of exosome-mediated siRNA delivery was demonstrated by the strong mRNA and protein knockdown of BACE1, a therapeutic target in Alzheimer's disease, in wild-type mice.