Exploring Structural Diversity of Microbe Secondary Metabolites Using OSMAC Strategy: A Literature Review.
TLDR
This review highlights important and successful examples using OSMAC approaches, which covers changing medium composition and cultivation status, co-cultivation with other strain(s), adding enzyme inhibitor(s) and MSM biosynthetic precursor(s).Abstract:
Microbial secondary metabolites (MSMs) have played and continue to play a highly significant role in the drug discovery and development process. Genetically, MSM chemical structures are biologically synthesized by microbial gene clusters. Recently, however, the speed of new bioactive MSM discovery has been slowing down due to consistent employment of conventional cultivation and isolation procedure. In order to alleviate this challenge, a number of new approaches have been developed. The strategy of one strain many compounds (OSMAC) has been shown as a simple and powerful tool that can activate many silent biogenetic gene clusters in microorganisms to make more natural products. This review highlights important and successful examples using OSMAC approaches, which covers changing medium composition and cultivation status, co-cultivation with other strain(s), adding enzyme inhibitor(s) and MSM biosynthetic precursor(s). Available evidences had shown that variation of cultivation condition is the most effective way to produce more MSMs and facilitate the discovery of new therapeutic agents.read more
Citations
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The DNMT1 target recognition domain resides in the N terminus. VOLUME 276 (2001) PAGES 6930-6936
Felipe D. Araujo,Sylvie Croteau,Andrew D. Slack,Snezana Milutinovic,Pascal Bigey,Gerald B. Price,Maria Zannis-Hadjopoulos,Moshe Szyf +7 more
TL;DR: The results now indicate that the DNMT1-PCNA interaction can be disrupted by substrate binding to theDNMT1 N terminus, and point toward new directions in the understanding of the structure-function of DN MT1.
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The essentials of marine biotechnology.
Ana Rotter,Michele Barbier,Francesco Bertoni,Atle M. Bones,Leonor Cancela,Jens Carlsson,Maria Carvalho,Marta Cegłowska,Jeronimo Chirivella-Martorell,Meltem Conk Dalay,Mercedes Cueto,Thanos Dailianis,Irem Deniz,Ana Diaz-Marrero,Dragana Drakulović,Arita Dubnika,Christine Edwards,Hjörleifur Einarsson,Ayşegül Erdoğan,O. Tufan Eroldoğan,David Ezra,Stefano Fazi,Richard J. FitzGerald,Laura M. Gargan,Susana P. Gaudêncio,Marija Gligora Udovič,Nadica Ivošević DeNardis,Rósa Jónsdóttir,Marija Katarzyte,Katja Klun,Jonne Kotta,Leila Ktari,Zrinka Ljubešić,Lada Lukić Bilela,Manolis Mandalakis,Alexia Massa-Gallucci,Inga Matijosyte,Hanna Mazur-Marzec,Mohamed Mehiri,Søren Laurentius Nielsen,Lucie Novoveská,Donata Overlinge,Giuseppe Perale,Ramasamy Praveenkumar,Céline Rebours,Thorsten Reinsch,Fernando Reyes,Baruch Rinkevich,Johan Robbens,Eric Röttinger,Vita Rudovica,Jerica Sabotič,Ivo Safarik,Siret Talve,Deniz Tasdemir,Xenia Theodotou Schneider,Olivier Thomas,Anna Toruńska-Sitarz,Giovanna Cristina Varese,Marlen I. Vasquez +59 more
TL;DR: In this article, the authors synthesize the essence, opportunities, responsibilities, and challenges encountered in marine biotechnology and outline the attainment and valorization of directly derived or bio-inspired products from marine organisms.
Journal ArticleDOI
Fungal Endophytes as Efficient Sources of Plant-Derived Bioactive Compounds and Their Prospective Applications in Natural Product Drug Discovery: Insights, Avenues, and Challenges.
TL;DR: In this paper, a review of plant-derived medicinal compounds of several classes, including alkaloids, coumarins, flavonoids, glycosides, lignans, phenylpropanoids, quinones, saponins, terpenoids, and xanthones, is presented.
Journal ArticleDOI
Bioactive Compounds Isolated from Marine-Derived Microbes in China: 2009–2018
TL;DR: The rapid increase in the number of publications in the field is perhaps most notable, which have increased more than sevenfold over the past decade, and suggests that China-based researchers will play a major role in marine microbial natural products drug discovery in years to come.
References
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Marine natural products.
TL;DR: This review covers the literature published in 2014 for marine natural products, with 1116 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.
Journal ArticleDOI
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking
Mingxun Wang,Jeremy Carver,Vanessa V. Phelan,Laura M. Sanchez,Neha Garg,Yao Peng,Don D. Nguyen,Jeramie D. Watrous,Clifford A. Kapono,Tal Luzzatto-Knaan,Carla Porto,Amina Bouslimani,Alexey V. Melnik,Michael J. Meehan,Wei-Ting Liu,Max Crüsemann,Paul D. Boudreau,Eduardo Esquenazi,Mario Sandoval-Calderón,Roland D. Kersten,Laura A. Pace,Robert A. Quinn,Katherine R. Duncan,Cheng-Chih Hsu,Dimitrios J. Floros,Ronnie G. Gavilan,Karin Kleigrewe,Trent R. Northen,Rachel J. Dutton,Delphine Parrot,Erin E. Carlson,Bertrand Aigle,Charlotte Frydenlund Michelsen,Lars Jelsbak,Christian Sohlenkamp,Pavel A. Pevzner,Anna Edlund,Anna Edlund,Jeffrey S. McLean,Jeffrey S. McLean,Jörn Piel,Brian T. Murphy,Lena Gerwick,Chih-Chuang Liaw,Yu-Liang Yang,Hans-Ulrich Humpf,Maria Maansson,Robert A. Keyzers,Amy C. Sims,Andrew R. Johnson,Ashley M. Sidebottom,Brian E. Sedio,Andreas Klitgaard,Charles B. Larson,Charles B. Larson,Cristopher A. Boya P.,Daniel Torres-Mendoza,David Gonzalez,Denise Brentan Silva,Denise Brentan Silva,Lucas Miranda Marques,Daniel P. Demarque,Egle Pociute,Ellis C. O’Neill,Enora Briand,Enora Briand,Eric J. N. Helfrich,Eve A. Granatosky,Evgenia Glukhov,Florian Ryffel,Hailey Houson,Hosein Mohimani,Jenan J. Kharbush,Yi Zeng,Julia A. Vorholt,Kenji L. Kurita,Pep Charusanti,Kerry L. McPhail,Kristian Fog Nielsen,Lisa Vuong,Maryam Elfeki,Matthew F. Traxler,Niclas Engene,Nobuhiro Koyama,Oliver B. Vining,Ralph S. Baric,Ricardo Pianta Rodrigues da Silva,Samantha J. Mascuch,Sophie Tomasi,Stefan Jenkins,Venkat R. Macherla,Thomas Hoffman,Vinayak Agarwal,Philip G. Williams,Jingqui Dai,Ram P. Neupane,Joshua R. Gurr,Andrés M. C. Rodríguez,Anne Lamsa,Chen Zhang,Kathleen Dorrestein,Brendan M. Duggan,Jehad Almaliti,Pierre-Marie Allard,Prasad Phapale,Louis-Félix Nothias,Theodore Alexandrov,Marc Litaudon,Jean-Luc Wolfender,Jennifer E. Kyle,Thomas O. Metz,Tyler Peryea,Dac-Trung Nguyen,Danielle VanLeer,Paul Shinn,Ajit Jadhav,Rolf Müller,Katrina M. Waters,Wenyuan Shi,Xueting Liu,Lixin Zhang,Rob Knight,Paul R. Jensen,Bernhard O. Palsson,Kit Pogliano,Roger G. Linington,Marcelino Gutiérrez,Norberto Peporine Lopes,William H. Gerwick,William H. Gerwick,Bradley S. Moore,Bradley S. Moore,Pieter C. Dorrestein,Pieter C. Dorrestein,Nuno Bandeira,Nuno Bandeira +135 more
TL;DR: In GNPS, crowdsourced curation of freely available community-wide reference MS libraries will underpin improved annotations and data-driven social-networking should facilitate identification of spectra and foster collaborations.
Journal ArticleDOI
Big effects from small changes: Possible ways to explore nature's chemical diversity
TL;DR: The systematic alteration of easily accessible cultivation parameters in order to increase the number of secondary metabolites available from one microbial source is investigated and the OSMAC approach seems to be a useful tool to detect those metabolites that are postulated to be the final products of an amazing number of typical secondary metabolites gene clusters identified in several microorganisms.
Journal ArticleDOI
Natural products from plant-associated microorganisms: distribution, structural diversity, bioactivity, and implications of their occurrence.
TL;DR: The structures of over 230 metabolites isolated and characterized from over 70 plant-associated microbial strains during the past four years are presented with information on their hosts, culture conditions, and biological activities.
Journal ArticleDOI
Intimate bacterial–fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans
Volker Schroeckh,Kirstin Scherlach,Hans-Wilhelm Nützmann,Ekaterina Shelest,Wolfgang Schmidt-Heck,Julia Schuemann,Karin Martin,Christian Hertweck,Axel A. Brakhage +8 more
TL;DR: Results provide evidence of specific interaction among microorganisms belonging to different domains and support the hypothesis that not only diffusible signals but intimate physical interactions contribute to the communication among micro organisms and induction of otherwise silent biosynthesis genes.
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