GENEVESTIGATOR. Arabidopsis Microarray Database and Analysis Toolbox
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TLDR
Genevestigator as mentioned in this paper is a web-browser interface for gene expression analysis using Affymetrix GeneChip data, which allows users to retrieve the expression patterns of individual genes throughout chosen environmental conditions, growth stages, or organs.Abstract:
High-throughput gene expression analysis has become a frequent and powerful research tool in biology. At present, however, few software applications have been developed for biologists to query large microarray gene expression databases using a Web-browser interface. We present GENEVESTIGATOR, a database and Web-browser data mining interface for Affymetrix GeneChip data. Users can query the database to retrieve the expression patterns of individual genes throughout chosen environmental conditions, growth stages, or organs. Reversely, mining tools allow users to identify genes specifically expressed during selected stresses, growth stages, or in particular organs. Using GENEVESTIGATOR, the gene expression profiles of more than 22,000 Arabidopsis genes can be obtained, including those of 10,600 currently uncharacterized genes. The objective of this software application is to direct gene functional discovery and design of new experiments by providing plant biologists with contextual information on the expression of genes. The database and analysis toolbox is available as a community resource at https://www.genevestigator.ethz.ch.read more
Citations
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Journal ArticleDOI
Abscisic acid signaling is controlled by a BRANCHED1/HD-ZIP I cascade in Arabidopsis axillary buds.
Eduardo González-Grandío,Alice Pajoro,José Manuel Franco-Zorrilla,Carlos Tarancón,Richard G. H. Immink,Pilar Cubas +5 more
TL;DR: Inside the buds, the TEOSINTE BRANCHED1, CYCLOIDEA, PCF (TCP) transcriptional regulator BRAN CHED1 (BRC1) binds to and positively regulates the transcription of three related Homeodomain leucine zipper protein (HD-ZIP)-encoding genes, which enhance 9-CIS-EPOXICAROTENOID DIOXIGENASE 3 (NCED3) expression, lead
Journal ArticleDOI
The structure, function and regulation of the nodulin 26-like intrinsic protein family of plant aquaglyceroporins.
TL;DR: The nodulin 26-like intrinsic protein family is a group of highly conserved multifunctional major intrinsic proteins that are unique to plants, and which transport a variety of uncharged solutes ranging from water to ammonia to glycerol.
Journal ArticleDOI
A systems biology perspective on the role of WRKY transcription factors in drought responses in plants
TL;DR: A multidisciplinary approach with successful integration of a whole range of -omics technologies will not only define the system, but also provide new gene targets for both transgenic approaches and marker-assisted selection.
Journal ArticleDOI
MYB10 and MYB72 are required for growth under iron-limiting conditions.
TL;DR: Evidence is provided that MYB10 and MYB72 act early in the iron-deficiency regulatory cascade to drive gene expression of NAS4 and are essential for plant survival under iron deficiency.
Journal ArticleDOI
Extranuclear protection of chromosomal DNA from oxidative stress
Sandy Vanderauwera,Nobuhiro Suzuki,Gad Miller,Brigitte van de Cotte,Stijn Morsa,Jean-Luc Ravanat,Alicia Hegie,Christian Triantaphylidès,Vladimir Shulaev,Marc Van Montagu,Frank Van Breusegem,Ron Mittler +11 more
TL;DR: It is shown that protection of nuclear DNA in plants requires a coordinated function of ROS-scavenging pathways residing in the cytosol and peroxisomes, demonstrating that nuclear ROS scavengers such as peroxiredoxin and glutathione are insufficient to safeguard DNA integrity.
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