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Open AccessJournal ArticleDOI

Human Proteinpedia enables sharing of human protein data.

Suresh Mathivanan, +163 more
- 01 Feb 2008 - 
- Vol. 26, Iss: 2, pp 164-167
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TLDR
MMCD is a practical tool for expediting the time-consuming steps of identifying and researching small molecules and is compatible with both NMR and MS data and facilitates high-throughput metabolomics investigations.
Abstract
Proteomic technologies, such as yeast two-hybrid, mass spectrometry (MS), protein/peptide arrays and fluorescence microscopy, yield multi-dimensional data sets, which are often quite large and either not published or published as supplementary information that is not easily searchable. Without a system in place for standardizing and sharing data, it is not fruitful for the biomedical community to contribute these types of data to centralized repositories.

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Journal ArticleDOI

Towards a knowledge-based Human Protein Atlas

TL;DR: The analysis here suggests that state stem cell funding programs are sufficiently large and established that simply ending the programs, at least in the absence of substantial investment in the field by other funding sources, could have deleterious effects.
Journal ArticleDOI

Selected reaction monitoring for quantitative proteomics: a tutorial

TL;DR: This tutorial explains the application of SRM for quantitative proteomics, including the selection of proteotypic peptides and the optimization and validation of transitions, and normalization and various factors affecting sensitivity and accuracy are discussed.
Journal ArticleDOI

Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation

Hina Kalra, +55 more
- 18 Dec 2012 - 
TL;DR: Vesiclepedia is a community-annotated compendium of molecular data on extracellular vesicles that aims to provide a single authoritative source for information on vesicle structure and function.
Journal ArticleDOI

Parallel Reaction Monitoring for High Resolution and High Mass Accuracy Quantitative, Targeted Proteomics

TL;DR: This work proposes a new targeted proteomics paradigm centered on the use of next generation, quadrupole-equipped high resolution and accurate mass instruments: parallel reaction monitoring (PRM), and suggests that PRM will be a promising new addition to the quantitative proteomics toolbox.
References
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Journal ArticleDOI

Gene Ontology: tool for the unification of biology

TL;DR: The goal of the Gene Ontology Consortium is to produce a dynamic, controlled vocabulary that can be applied to all eukaryotes even as knowledge of gene and protein roles in cells is accumulating and changing.
Journal ArticleDOI

Internet encyclopaedias go head to head

Jim Giles
- 14 Dec 2005 - 
TL;DR: Jimmy Wales' Wikipedia comes close to Britannica in terms of the accuracy of its science entries, a Nature investigation finds.
Journal ArticleDOI

A Human Protein Atlas for Normal and Cancer Tissues Based on Antibody Proteomics

TL;DR: A new publicly available database containing, in the first version, ∼400,000 high resolution images corresponding to more than 700 antibodies toward human proteins, providing a knowledge base for functional studies and to allow queries about protein profiles in normal and disease tissues.
Journal ArticleDOI

Development of Human Protein Reference Database as an Initial Platform for Approaching Systems Biology in Humans

TL;DR: The Human Protein Reference Database (HPRD) as mentioned in this paper is an object database that integrates a wealth of information relevant to the function of human proteins in health and disease, including protein-protein interactions, posttranslational modifications, enzyme/substrate relationships, disease associations, tissue expression, and subcellular localization.
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