Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin
Katherine A. Hoadley,Christina Yau,Denise M. Wolf,Andrew D. Cherniack,David Tamborero,Sam Ng,Max D M Leiserson,Beifang Niu,Michael D. McLellan,Vladislav Uzunangelov,Jiashan Zhang,Cyriac Kandoth,Rehan Akbani,Hui Shen,Larsson Omberg,Andy Chu,Adam A. Margolin,Laura J. van't Veer,Nuria Lopez-Bigas,Nuria Lopez-Bigas,Peter W. Laird,Benjamin J. Raphael,Li Ding,A. Gordon Robertson,Lauren Averett Byers,Gordon B. Mills,John N. Weinstein,Carter Van Waes,Zhong Chen,Eric A. Collisson,Christopher C. Benz,Charles M. Perou,Joshua M. Stuart +32 more
TLDR
An integrative analysis using five genome-wide platforms and one proteomic platform on 3,527 specimens from 12 cancer types revealed a unified classification into 11 major subtypes, revealing several distinct cancer types found to converge into common subtypes.About:
This article is published in Cell.The article was published on 2014-08-14 and is currently open access. It has received 1259 citations till now.read more
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Salmon provides fast and bias-aware quantification of transcript expression
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The consensus molecular subtypes of colorectal cancer
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TL;DR: An international consortium dedicated to large-scale data sharing and analytics across expert groups is formed, showing marked interconnectivity between six independent classification systems coalescing into four consensus molecular subtypes (CMSs) with distinguishing features.
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The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge.
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Genomic analyses identify molecular subtypes of pancreatic cancer
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Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response
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The cancer genome atlas pan-cancer analysis project
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