Pathway-Specific Dopamine Abnormalities in Schizophrenia.
Jodi J. Weinstein,Muhammad Omar Chohan,Mark Slifstein,Lawrence S. Kegeles,Holly Moore,Anissa Abi-Dargham +5 more
TLDR
The dopaminergic innervation within the individual projection fields is discussed to provide a topographical map of this dual dysregulation in schizophrenia and potential cellular and circuit-based mechanisms for brain region-dependent alterations in dopamine parameters are explored.About:
This article is published in Biological Psychiatry.The article was published on 2017-01-01 and is currently open access. It has received 224 citations till now. The article focuses on the topics: Dopaminergic & Dopamine.read more
Citations
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The Role of Genes, Stress, and Dopamine in the Development of Schizophrenia.
Oliver D. Howes,Oliver D. Howes,Robert A. McCutcheon,Robert A. McCutcheon,Michael John Owen,Robin M. Murray +5 more
TL;DR: A model is presented of how genes and environmental factors may sensitize the dopamine system so that it is vulnerable to acute stress, leading to progressive dysregulation and the onset of psychosis.
Journal ArticleDOI
Antipsychotics: Mechanisms underlying clinical response and side-effects and novel treatment approaches based on pathophysiology.
TL;DR: Elevated striatal dopamine synthesis and release capacity in dorsal regions of the striatum underlies the positive symptoms of psychosis and suggests reduced dopamine release in cortical regions contributes to cognitive and negative symptoms.
Journal ArticleDOI
One-pot synthesis of Au-Cu2O/rGO nanocomposite based electrochemical sensor for selective and simultaneous detection of dopamine and uric acid
TL;DR: In this article, an electrochemical sensor based on an Au-Cu2O/rGO nanocomposite for selective and simultaneous detection of dopamine and uric acid was developed.
Journal ArticleDOI
The origin of NMDA receptor hypofunction in schizophrenia
Kazu Nakazawa,Kiran Sapkota +1 more
TL;DR: The studies discussed here support a central role for GABAergic abnormalities in the context of NMDAR hypofunction and suggest potential therapeutic strategies to improve the function of fast-spiking neurons.
Journal ArticleDOI
A Perceptual Inference Mechanism for Hallucinations Linked to Striatal Dopamine
Clifford M. Cassidy,Peter D. Balsam,Jodi J. Weinstein,R J Rosengard,Mark Slifstein,Nathaniel D. Daw,Anissa Abi-Dargham,Anissa Abi-Dargham,Guillermo Horga +8 more
TL;DR: A novel dopamine-dependent mechanism for perceptual modulation in physiological conditions is outlined and it is suggested that this mechanism may confer vulnerability to hallucinations in hyper-dopaminergic states underlying psychosis.
References
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