Journal ArticleDOI
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
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TLDR
The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.Abstract:
The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with dinical and other paraclinical diagnostic methods. The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including "monosymptomatic" disease suggestive of MS, disease with a typical relapsing-remitting course, and disease with insidious progression, without clear attacks and remissions. Previously used terms such as "clinically definite" and "probable MS" are no longer recommended. The outcome of a diagnostic evaluation is either MS, "possible MS" (for those at risk for MS, but for whom diagnostic evaluation is equivocal), or "not MS."read more
Citations
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Journal ArticleDOI
Exercise therapy for multiple sclerosis
TL;DR: It is suggested that exercise therapy can be beneficial for patients with MS not experiencing an exacerbation and there is an urgent need for consensus on a core set of outcome measures to be used in exercise trials.
Journal ArticleDOI
Natural History of Multiple Sclerosis with Childhood Onset
TL;DR: Patients with childhood onset reach these different critical phases of the disease at a younger age than patients with adult onset, therefore contradicting the notion of a more favorable prognosis in this age group.
Journal ArticleDOI
Thalamic atrophy and cognition in multiple sclerosis
Maria K. Houtchens,Ralph H.B. Benedict,Ronald J. Killiany,Jitendra Sharma,Zeenat Jaisani,Baljinder Singh,Bianca Weinstock-Guttman,Charles R.G. Guttmann,Rohit Bakshi +8 more
TL;DR: Thalamic atrophy is a clinically relevant biomarker of the neurodegenerative disease process in multiple sclerosis, suggesting clinical relevance of damage to surrounding structures, such as the thalamus.
Journal ArticleDOI
Higher 25-hydroxyvitamin D is associated with lower relapse risk in multiple sclerosis.
Steve Simpson,Bruce V. Taylor,Leigh Blizzard,Anne-Louise Ponsonby,Fotini Pittas,Helen Tremlett,Terence Dwyer,Peter Gies,Ingrid van der Mei +8 more
TL;DR: This study investigated whether higher levels of serum 25‐hydroxyvitamin D (25‐OH‐D) were associated with a lower risk of relapses in people with MS.
Journal ArticleDOI
Incidence and prevalence of multiple sclerosis in Europe: a systematic review.
Elaine Kingwell,James J. Marriott,Nathalie Jette,Tamara Pringsheim,Naila Makhani,Sarah A. Morrow,John D. Fisk,John D. Fisk,Charity Evans,Sarah Gabrielle Beland,Sophie Kulaga,Jonathan Dykeman,Christina Wolfson,Marcus W. Koch,Ruth Ann Marrie +14 more
TL;DR: Despite the breadth of the literature on the epidemiology of MS in Europe, inter-study comparisons are hampered by the lack of standardization and further research should focus on regions not yet studied and the evaluation of ethnic differences in MS prevalence and incidence.
References
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Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Journal ArticleDOI
The clinical course of neuromyelitis optica (Devic's syndrome)
TL;DR: Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS, and patients with relapsing optic neuritis and myelitis may have neuromyeliitis opticas rather than MS.
Journal ArticleDOI
Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis.
George A. Schumacher,Gilbert Beebe,Robert F. Kibler,Leonard T. Kurland,John F. Kurtzke,Fletcher McDowell,Benedict Nagler,William A. Sibley,Wallace W. Tourtellotte,Thomas L. Willmon +9 more
TL;DR: Since its etiology and pathogenesis have eluded detection, it is not surprising that therapeutic attempts have been empiric and often unscientific.
Journal ArticleDOI
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
Frederik Barkhof,Massimo Filippi,David Miller,Philip Scheltens,Adriana Campi,Chris H. Polman,Giancarlo Comi,Herman J. Adèr,N. A. Losseff,Jacob Valk +9 more
TL;DR: It is concluded that a four-parameter dichotomized MRI model including gadolinium-enhancement, juxtacortical, infratentorial and periventricular lesions best predicts conversion to clinically definite multiple sclerosis.
Journal ArticleDOI
MRI in the diagnosis of MS A prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT
Donald W. Paty,Joel Oger,Lorne F. Kastrukoff,S. A. Hashimoto,John P. Hooge,Andrew Eisen,K. A. Eisen,S. J. Purves,M. D. Low,V. Brandejs,W. D. Robertson,David Kb Li +11 more
TL;DR: MRI was the best method for demonstrating dissemination in space and laboratory-supported definite MS (LSDMS) could be diagnosed in 85 patients of the total 200, and MRI predicted that diagnosis in 18/19 (95%).
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