Journal ArticleDOI
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
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TLDR
The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.Abstract:
The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with dinical and other paraclinical diagnostic methods. The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including "monosymptomatic" disease suggestive of MS, disease with a typical relapsing-remitting course, and disease with insidious progression, without clear attacks and remissions. Previously used terms such as "clinically definite" and "probable MS" are no longer recommended. The outcome of a diagnostic evaluation is either MS, "possible MS" (for those at risk for MS, but for whom diagnostic evaluation is equivocal), or "not MS."read more
Citations
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Journal ArticleDOI
Reproductive decision making after the diagnosis of multiple sclerosis (MS).
Sura Alwan,I M Yee,M Dybalski,Colleen Guimond,Emily Dwosh,Talitha Greenwood,Rachel Butler,A D Sadovnick +7 more
TL;DR: It is indicated that an MS diagnosis does not completely deter the consideration of childbearing in MS patients of both genders.
Journal ArticleDOI
Epidemiology of multiple sclerosis in south-western Sardinia:
Eleonora Cocco,Claudia Sardu,Rita Massa,E Mamusa,Luigina Musu,Paola Ferrigno,Maurizio Melis,Cristina Montomoli,Virginia Valeria Ferretti,Giancarlo Coghe,Giuseppe Fenu,Jessica Frau,Lorena Lorefice,Nicola Carboni,Paolo Contu,Maria Giovanna Marrosu +15 more
TL;DR: Sardinia is confirmed as a high-risk area for multiple sclerosis and the relevance of genetic factors in MS is supported, as evidenced in St Peter Island, but an unexpectedly high MS prevalence in one village is found, in particular in males, suggesting an environmental influence on MS occurrence.
Journal ArticleDOI
Rasch analysis of the Multiple Sclerosis Impact Scale (MSIS-29)
TL;DR: In this first study to use Rasch analysis to fully assess the psychometric properties of the MSIS-29 support was found for the two subscales but not for the use of the total scale.
Journal ArticleDOI
The afferent visual pathway: designing a structural-functional paradigm of multiple sclerosis.
TL;DR: The parameters and merits of the AVP model, a functionally eloquent system that is amenable to interrogation with highly reliable and reproducible tests that can be used to define a structural-functional paradigm of CNS injury, are highlighted.
Journal ArticleDOI
Frequency of cognitive impairment dramatically increases during the first 5 years of multiple sclerosis
Françoise Reuter,Wafaa Zaaraoui,Lydie Crespy,Anthony Faivre,Audrey Rico,Irina Malikova,Elisabeth Soulier,Patrick Viout,Jean-Philippe Ranjeva,Jean Pelletier,Bertrand Audoin +10 more
TL;DR: It is shown that the frequency of cognitive impairment increases dramatically during the first 5 years following a CIS and that the cognitive status at year 5 was predictable by conventional MRI parameters recorded at baseline.
References
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Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Journal ArticleDOI
The clinical course of neuromyelitis optica (Devic's syndrome)
TL;DR: Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS, and patients with relapsing optic neuritis and myelitis may have neuromyeliitis opticas rather than MS.
Journal ArticleDOI
Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis.
George A. Schumacher,Gilbert Beebe,Robert F. Kibler,Leonard T. Kurland,John F. Kurtzke,Fletcher McDowell,Benedict Nagler,William A. Sibley,Wallace W. Tourtellotte,Thomas L. Willmon +9 more
TL;DR: Since its etiology and pathogenesis have eluded detection, it is not surprising that therapeutic attempts have been empiric and often unscientific.
Journal ArticleDOI
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
Frederik Barkhof,Massimo Filippi,David Miller,Philip Scheltens,Adriana Campi,Chris H. Polman,Giancarlo Comi,Herman J. Adèr,N. A. Losseff,Jacob Valk +9 more
TL;DR: It is concluded that a four-parameter dichotomized MRI model including gadolinium-enhancement, juxtacortical, infratentorial and periventricular lesions best predicts conversion to clinically definite multiple sclerosis.
Journal ArticleDOI
MRI in the diagnosis of MS A prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT
Donald W. Paty,Joel Oger,Lorne F. Kastrukoff,S. A. Hashimoto,John P. Hooge,Andrew Eisen,K. A. Eisen,S. J. Purves,M. D. Low,V. Brandejs,W. D. Robertson,David Kb Li +11 more
TL;DR: MRI was the best method for demonstrating dissemination in space and laboratory-supported definite MS (LSDMS) could be diagnosed in 85 patients of the total 200, and MRI predicted that diagnosis in 18/19 (95%).
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