Journal ArticleDOI
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
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TLDR
The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.Abstract:
The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with dinical and other paraclinical diagnostic methods. The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including "monosymptomatic" disease suggestive of MS, disease with a typical relapsing-remitting course, and disease with insidious progression, without clear attacks and remissions. Previously used terms such as "clinically definite" and "probable MS" are no longer recommended. The outcome of a diagnostic evaluation is either MS, "possible MS" (for those at risk for MS, but for whom diagnostic evaluation is equivocal), or "not MS."read more
Citations
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Temporal changes and geographical differences in multiple sclerosis phenotypes in Japanese: nationwide survey results over 30 years
Manabu Osoegawa,Jun Ichi Kira,T. Fukazawa,Kazuo Fujihara,Seiji Kikuchi,Makoto Matsui,Tatsuo Kohriyama,Gen Sobue,Takashi Yamamura,Y. Itoyama,Takahiko Saida,Kiyomi Sakata,Hirofumi Ochi,Takeshi Matsuoka +13 more
TL;DR: Findings suggest that MS phenotypes are drastically altered by environmental factors, such as latitude and “Westernization,” as well as in Japan.
Journal ArticleDOI
Atrophy mainly affects the limbic system and the deep grey matter at the first stage of multiple sclerosis
Bertrand Audoin,Wafaa Zaaraoui,Françoise Reuter,Audrey Rico,Irina Malikova,Sylviane Confort-Gouny,Patrick J. Cozzone,Jean Pelletier,Jean-Philippe Ranjeva +8 more
TL;DR: It is demonstrated that regional GM atrophy is present right after the first clinical event of multiple sclerosis and mainly affects the deep GM and the limbic system.
Journal ArticleDOI
The impact of sexual dysfunction on the quality of life measured by MSQoL-54 in patients with multiple sclerosis:
DK Tepavcevic,J. Kostic,ID Basuroski,Nebojsa Stojsavljevic,Tatjana Pekmezovic,Jelena Drulovic +5 more
TL;DR: The results reveal that frequent occurrence of SD in MS patients prominently affects all aspects of their quality of life.
Journal ArticleDOI
Genetics and the environment converge to dysregulate N -glycosylation in multiple sclerosis
Haik Mkhikian,Ani Grigorian,Carey F. Li,Hung-Lin Chen,Barbara L. Newton,Raymond W. Zhou,Christine Beeton,Sevan Torossian,Gevork Grikor Tatarian,Sung-Uk Lee,Ken S. Lau,Ken S. Lau,Erin Walker,Erin Walker,Katherine A. Siminovitch,Katherine A. Siminovitch,K. George Chandy,Zhaoxia Yu,James W. Dennis,James W. Dennis,Michael A. Demetriou +20 more
TL;DR: It is shown that MS risk modulators converge to alter N-glycosylation and/or CTLA-4 surface retention conditional on metabolism and vitamin D3, including genetic variants in interleukin-7 receptor-α (IL7RA*C), interleokin-2 receptor- α (IL2RA*T), MGAT1 (IVAVT−T) and CTLA
Journal ArticleDOI
Repetitive transcranial magnetic stimulation of the motor cortex ameliorates spasticity in multiple sclerosis.
Diego Centonze,Giacomo Koch,Viviana Versace,Francesco Mori,Stefano Rossi,Livia Brusa,K. Grossi,F. Torelli,Chiara Prosperetti,A. Cervellino,Girolama Alessandra Marfia,Paolo Stanzione,Maria Grazia Marciani,Laura Boffa,Giorgio Bernardi +14 more
TL;DR: Repetitive transcranial magnetic stimulation may improve spasticity in multiple sclerosis, and clinical improvement was long-lasting when the patients underwent 5 Hz rTMS treatment during a 2-week protocol.
References
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Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Journal ArticleDOI
The clinical course of neuromyelitis optica (Devic's syndrome)
TL;DR: Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS, and patients with relapsing optic neuritis and myelitis may have neuromyeliitis opticas rather than MS.
Journal ArticleDOI
Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis.
George A. Schumacher,Gilbert Beebe,Robert F. Kibler,Leonard T. Kurland,John F. Kurtzke,Fletcher McDowell,Benedict Nagler,William A. Sibley,Wallace W. Tourtellotte,Thomas L. Willmon +9 more
TL;DR: Since its etiology and pathogenesis have eluded detection, it is not surprising that therapeutic attempts have been empiric and often unscientific.
Journal ArticleDOI
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
Frederik Barkhof,Massimo Filippi,David Miller,Philip Scheltens,Adriana Campi,Chris H. Polman,Giancarlo Comi,Herman J. Adèr,N. A. Losseff,Jacob Valk +9 more
TL;DR: It is concluded that a four-parameter dichotomized MRI model including gadolinium-enhancement, juxtacortical, infratentorial and periventricular lesions best predicts conversion to clinically definite multiple sclerosis.
Journal ArticleDOI
MRI in the diagnosis of MS A prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT
Donald W. Paty,Joel Oger,Lorne F. Kastrukoff,S. A. Hashimoto,John P. Hooge,Andrew Eisen,K. A. Eisen,S. J. Purves,M. D. Low,V. Brandejs,W. D. Robertson,David Kb Li +11 more
TL;DR: MRI was the best method for demonstrating dissemination in space and laboratory-supported definite MS (LSDMS) could be diagnosed in 85 patients of the total 200, and MRI predicted that diagnosis in 18/19 (95%).
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