Journal ArticleDOI
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
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TLDR
The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.Abstract:
The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with dinical and other paraclinical diagnostic methods. The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including "monosymptomatic" disease suggestive of MS, disease with a typical relapsing-remitting course, and disease with insidious progression, without clear attacks and remissions. Previously used terms such as "clinically definite" and "probable MS" are no longer recommended. The outcome of a diagnostic evaluation is either MS, "possible MS" (for those at risk for MS, but for whom diagnostic evaluation is equivocal), or "not MS."read more
Citations
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Serum lipid profiles are associated with disability and MRI outcomes in multiple sclerosis
Bianca Weinstock-Guttman,Robert Zivadinov,Naeem Mahfooz,Ellen Carl,Allison Drake,Jaclyn Schneider,Barbara Teter,Sara Hussein,Bijal Mehta,Marc Weiskopf,Jacqueline Durfee,Niels Bergsland,Murali Ramanathan +12 more
TL;DR: Serum lipid profile has modest effects on disease progression in MS, and worsening disability is associated with higher levels of LDL, total cholesterol and triglycerides, and higher HDL isassociated with lower levels of acute inflammatory activity.
Journal ArticleDOI
Clinically isolated syndromes Predicting and delaying multiple sclerosis
TL;DR: Application of the McDonald criteria allows an earlier MS diagnosis by using new MRI lesions to define dissemination in time and may eventually prevent future axon pathology and progression of disability in this lifelong disease.
Journal ArticleDOI
Phase 2 trial of a DNA vaccine encoding myelin basic protein for multiple sclerosis.
Hideki Garren,William H. Robinson,Eva Krasulova,Eva Havrdova,Congor Nadj,Krzysztof Selmaj,Jacek Losy,Ilinka Nadj,Ernst-Wilhelm Radue,Brian A. Kidd,Jill Gianettoni,Karen Tersini,Paul J. Utz,Frank Valone,Lawrence Steinman +14 more
TL;DR: To evaluate the efficacy and safety of BHT‐3009 in relapsing‐remitting multiple sclerosis (MS) and to confirm that BHT-3009 causes immune tolerance, the drug is administered through a single injection into the central nervous system.
Journal ArticleDOI
First Clinical Study on Ultra-High-Field MR Imaging in Patients with Multiple Sclerosis: Comparison of 1.5T and 7T
K. Kollia,Stefan Maderwald,N. Putzki,Marc Schlamann,Jens M. Theysohn,Oliver Kraff,Mark E. Ladd,Michael Forsting,Isabel Wanke +8 more
TL;DR: In this paper, the authors investigated the potential of high-resolution imaging of MS lesions in vivo comparing 7T with conventional 1.5T and found that the 7T image was well tolerated and provided better visualization of gray matter and demonstrated structural abnormalities within the MS lesions themselves more effectively.
Journal ArticleDOI
A 3-year magnetic resonance imaging study of cortical lesions in relapse-onset multiple sclerosis.
Massimiliano Calabrese,Maria A. Rocca,M Atzori,Irene Mattisi,Alice Favaretto,Paola Perini,Paolo Gallo,Massimo Filippi +7 more
TL;DR: The occurrence, extent, and frequency of formation of cortical lesions in patients with relapsing‐remitting and secondary progressive multiple sclerosis and their relationship with cortical atrophy and disability progression are assessed.
References
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Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Journal ArticleDOI
The clinical course of neuromyelitis optica (Devic's syndrome)
TL;DR: Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS, and patients with relapsing optic neuritis and myelitis may have neuromyeliitis opticas rather than MS.
Journal ArticleDOI
Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis.
George A. Schumacher,Gilbert Beebe,Robert F. Kibler,Leonard T. Kurland,John F. Kurtzke,Fletcher McDowell,Benedict Nagler,William A. Sibley,Wallace W. Tourtellotte,Thomas L. Willmon +9 more
TL;DR: Since its etiology and pathogenesis have eluded detection, it is not surprising that therapeutic attempts have been empiric and often unscientific.
Journal ArticleDOI
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
Frederik Barkhof,Massimo Filippi,David Miller,Philip Scheltens,Adriana Campi,Chris H. Polman,Giancarlo Comi,Herman J. Adèr,N. A. Losseff,Jacob Valk +9 more
TL;DR: It is concluded that a four-parameter dichotomized MRI model including gadolinium-enhancement, juxtacortical, infratentorial and periventricular lesions best predicts conversion to clinically definite multiple sclerosis.
Journal ArticleDOI
MRI in the diagnosis of MS A prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT
Donald W. Paty,Joel Oger,Lorne F. Kastrukoff,S. A. Hashimoto,John P. Hooge,Andrew Eisen,K. A. Eisen,S. J. Purves,M. D. Low,V. Brandejs,W. D. Robertson,David Kb Li +11 more
TL;DR: MRI was the best method for demonstrating dissemination in space and laboratory-supported definite MS (LSDMS) could be diagnosed in 85 patients of the total 200, and MRI predicted that diagnosis in 18/19 (95%).
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