Journal ArticleDOI
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
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TLDR
The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.Abstract:
The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with dinical and other paraclinical diagnostic methods. The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including "monosymptomatic" disease suggestive of MS, disease with a typical relapsing-remitting course, and disease with insidious progression, without clear attacks and remissions. Previously used terms such as "clinically definite" and "probable MS" are no longer recommended. The outcome of a diagnostic evaluation is either MS, "possible MS" (for those at risk for MS, but for whom diagnostic evaluation is equivocal), or "not MS."read more
Citations
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Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype.
George P. Christophi,Michael Panos,Chad A. Hudson,Rebecca L. Christophi,Ross C. Gruber,Akos T. Mersich,Scott D. Blystone,Burk Jubelt,Paul T. Massa +8 more
TL;DR: Macrophages of MS patients display a deficiency of SHP-1 expression, heightened activation of STAT6, STAT1, and NF-κB and a corresponding inflammatory profile that may be important in controlling macrophage-mediated demyelination in MS.
Journal ArticleDOI
Metabolomic profiling in multiple sclerosis: insights into biomarkers and pathogenesis.
Stacey N. Reinke,David Broadhurst,Brian D. Sykes,Glen B. Baker,Ingrid Catz,Kenneth G. Warren,Christopher Power +6 more
TL;DR: CSF metabolomics have the capacity to yield quantitative biomarkers and insights into the pathogenesis of MS and multivariate hierarchal cluster analysis indicated a high correlation within the metabolite profiles, significantly clustering samples into the two clinical groups.
Journal ArticleDOI
Adaptive robot training for the treatment of incoordination in Multiple Sclerosis
E. Vergaro,Valentina Squeri,Valentina Squeri,Giampaolo Brichetto,Maura Casadio,Maura Casadio,Pietro Morasso,Pietro Morasso,Claudio Solaro,Vittorio Sanguineti,Vittorio Sanguineti +10 more
TL;DR: A robot therapy protocol aimed at the rehabilitation of incoordination in MS subjects is developed and tested, suggesting a potential benefit of a short-term, customized, and adaptive robot therapy for MS subjects.
Journal ArticleDOI
Clinical and diagnostic aspects of multiple sclerosis and acute monophasic encephalomyelitis in pediatric patients: a single centre prospective study.
M Atzori,Pier Antonio Battistella,Paola Perini,Massimiliano Calabrese,M Fontanin,A. M. Laverda,Agnese Suppiej,Paola Drigo,Paola Grossi,Luciano Rinaldi,Paolo Gallo +10 more
TL;DR: A pattern of demographic, clinical, neuroimaging, and laboratory findings that can help to distinguish, at clinical onset, children suffering from ADEM from those who will develop MS is depicted.
Journal ArticleDOI
Multiple sclerosis risk loci and disease severity in 7,125 individuals from 10 studies.
Michaela F. George,Farren B.S. Briggs,Xiaorong Shao,Milena A. Gianfrancesco,Ingrid Kockum,Hanne F. Harbo,Elisabeth Gulowsen Celius,Steffan D. Bos,Anna Karin Hedström,Ling Shen,Allan L. Bernstein,Lars Alfredsson,Jan Hillert,Tomas Olsson,Nikolaos A. Patsopoulos,Philip L. De Jager,Annette Bang Oturai,Helle Bach Søndergaard,Finn Sellebjerg,Per Soelberg Sørensen,Refujia Gomez,Stacy J. Caillier,Bruce A.C. Cree,Jorge R. Oksenberg,Stephen L. Hauser,Sandra D'Alfonso,Maurizio Leone,Filippo Martinelli Boneschi,Melissa Sorosina,Ingrid van der Mei,Bruce V. Taylor,Yuan Zhou,Catherine Schaefer,Lisa F. Barcellos +33 more
TL;DR: Results suggest that the investigated MS genetic risk variants are not associated with MSSS, even after controlling for potential confounders, which is critical to understanding disease mechanisms and guiding development of effective treatments.
References
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Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Journal ArticleDOI
The clinical course of neuromyelitis optica (Devic's syndrome)
TL;DR: Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS, and patients with relapsing optic neuritis and myelitis may have neuromyeliitis opticas rather than MS.
Journal ArticleDOI
Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis.
George A. Schumacher,Gilbert Beebe,Robert F. Kibler,Leonard T. Kurland,John F. Kurtzke,Fletcher McDowell,Benedict Nagler,William A. Sibley,Wallace W. Tourtellotte,Thomas L. Willmon +9 more
TL;DR: Since its etiology and pathogenesis have eluded detection, it is not surprising that therapeutic attempts have been empiric and often unscientific.
Journal ArticleDOI
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
Frederik Barkhof,Massimo Filippi,David Miller,Philip Scheltens,Adriana Campi,Chris H. Polman,Giancarlo Comi,Herman J. Adèr,N. A. Losseff,Jacob Valk +9 more
TL;DR: It is concluded that a four-parameter dichotomized MRI model including gadolinium-enhancement, juxtacortical, infratentorial and periventricular lesions best predicts conversion to clinically definite multiple sclerosis.
Journal ArticleDOI
MRI in the diagnosis of MS A prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT
Donald W. Paty,Joel Oger,Lorne F. Kastrukoff,S. A. Hashimoto,John P. Hooge,Andrew Eisen,K. A. Eisen,S. J. Purves,M. D. Low,V. Brandejs,W. D. Robertson,David Kb Li +11 more
TL;DR: MRI was the best method for demonstrating dissemination in space and laboratory-supported definite MS (LSDMS) could be diagnosed in 85 patients of the total 200, and MRI predicted that diagnosis in 18/19 (95%).
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