Journal ArticleDOI
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
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TLDR
The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.Abstract:
The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with dinical and other paraclinical diagnostic methods. The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including "monosymptomatic" disease suggestive of MS, disease with a typical relapsing-remitting course, and disease with insidious progression, without clear attacks and remissions. Previously used terms such as "clinically definite" and "probable MS" are no longer recommended. The outcome of a diagnostic evaluation is either MS, "possible MS" (for those at risk for MS, but for whom diagnostic evaluation is equivocal), or "not MS."read more
Citations
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Journal ArticleDOI
OSMS is NMO, but not MS: proven clinically and pathologically
Journal ArticleDOI
MicroRNA and mRNA expression profile screening in multiple sclerosis patients to unravel novel pathogenic steps and identify potential biomarkers.
Filippo Martinelli-Boneschi,Chiara Fenoglio,Paola Brambilla,Melissa Sorosina,Giacomo Giacalone,Federica Esposito,Maria Serpente,Claudia Cantoni,Elisa Ridolfi,Mariaemma Rodegher,Lucia Moiola,Bruno Colombo,Milena De Riz,Vittorio Martinelli,Elio Scarpini,Giancarlo Comi,Daniela Galimberti +16 more
TL;DR: A total of 104 miRNAs have been identified as deregulated in MS patients; 2/10 which ranked highest (let-7g and miR-150) have been validated in a replication sample, leading to the identification of putative target genes.
Journal ArticleDOI
The DYMUS questionnaire for the assessment of dysphagia in multiple sclerosis
Roberto Bergamaschi,P. Crivelli,C. Rezzani,Francesco Patti,Claudio Solaro,Paolo Rossi,Domenico A. Restivo,Davide Maimone,Alfredo Romani,Stefano Bastianello,Eleonora Tavazzi,Emanuele D'Amico,Cristina Montomoli,Vittorio Cosi +13 more
TL;DR: DYMUS demonstrated to be an easy and consistent tool to detect dysphagia and its main characteristics in MS and can be used for preliminary selection of patients to submit to more specific instrumental analyses, and to direct toward programs for prevention of aspiration.
Journal ArticleDOI
Prodromal symptoms of multiple sclerosis in primary care
Giulio Disanto,Chiara Zecca,Sharon MacLachlan,Rosaria Sacco,Lahiru Handunnetthi,Ute C. Meier,Alex Simpson,Laura McDonald,Andrea Rossi,Pascal Benkert,Jens Kuhle,Sreeram V Ramagopalan,Claudio Gobbi +12 more
TL;DR: Early diagnosis and treatment initiation significantly influence long‐term disability outcome in multiple sclerosis and this work aimed at identifying prodromal symptoms of MS in primary care settings.
Journal ArticleDOI
25-hydroxyvitamin D in cerebrospinal fluid during relapse and remission of multiple sclerosis.
Trygve Holmøy,Stine Marit Moen,Thomas A Gundersen,Michael F. Holick,Enrico Fainardi,Massimiliano Castellazzi,Ilaria Casetta +6 more
TL;DR: Neither the concentrations of 25-hydroxyvitamin D in cerebrospinal fluid or serum nor their ratio were associated with the presence of relapses or gadolinium-enhanced lesions, and these results do not support that 25-Hydroxyv vitamin D is actively transported to the cerebroSpinal fluid, or that the Cerebrosp spinal fluid levels or their ratio exert a major impact on MS activity.
References
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Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Journal ArticleDOI
The clinical course of neuromyelitis optica (Devic's syndrome)
TL;DR: Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS, and patients with relapsing optic neuritis and myelitis may have neuromyeliitis opticas rather than MS.
Journal ArticleDOI
Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis.
George A. Schumacher,Gilbert Beebe,Robert F. Kibler,Leonard T. Kurland,John F. Kurtzke,Fletcher McDowell,Benedict Nagler,William A. Sibley,Wallace W. Tourtellotte,Thomas L. Willmon +9 more
TL;DR: Since its etiology and pathogenesis have eluded detection, it is not surprising that therapeutic attempts have been empiric and often unscientific.
Journal ArticleDOI
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
Frederik Barkhof,Massimo Filippi,David Miller,Philip Scheltens,Adriana Campi,Chris H. Polman,Giancarlo Comi,Herman J. Adèr,N. A. Losseff,Jacob Valk +9 more
TL;DR: It is concluded that a four-parameter dichotomized MRI model including gadolinium-enhancement, juxtacortical, infratentorial and periventricular lesions best predicts conversion to clinically definite multiple sclerosis.
Journal ArticleDOI
MRI in the diagnosis of MS A prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT
Donald W. Paty,Joel Oger,Lorne F. Kastrukoff,S. A. Hashimoto,John P. Hooge,Andrew Eisen,K. A. Eisen,S. J. Purves,M. D. Low,V. Brandejs,W. D. Robertson,David Kb Li +11 more
TL;DR: MRI was the best method for demonstrating dissemination in space and laboratory-supported definite MS (LSDMS) could be diagnosed in 85 patients of the total 200, and MRI predicted that diagnosis in 18/19 (95%).
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