Journal ArticleDOI
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
Reads0
Chats0
TLDR
The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.Abstract:
The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with dinical and other paraclinical diagnostic methods. The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including "monosymptomatic" disease suggestive of MS, disease with a typical relapsing-remitting course, and disease with insidious progression, without clear attacks and remissions. Previously used terms such as "clinically definite" and "probable MS" are no longer recommended. The outcome of a diagnostic evaluation is either MS, "possible MS" (for those at risk for MS, but for whom diagnostic evaluation is equivocal), or "not MS."read more
Citations
More filters
Journal ArticleDOI
Idiopathic inflammatory-demyelinating diseases of the central nervous system
TL;DR: Precise classification of these disorders may have relevant prognostic and treatment implications, and might be helpful in distinguishing them from tumoral or infectious lesions, avoiding unnecessary aggressive diagnostic or therapeutic procedures.
Journal ArticleDOI
An adverse lipid profile is associated with disability and progression in disability, in people with MS
Prudence Tettey,Steve Simpson,Bruce V. Taylor,Leigh Blizzard,Anne-Louise Ponsonby,Terence Dwyer,Karam Kostner,Ingrid van der Mei +7 more
TL;DR: In this prospective population-based cohort study, an adverse lipid profile was associated with high levels of MS disability and disease progression, and improving serum lipids may be beneficial for MS patients to potentially improve clinical outcomes and vascular comorbidities.
Journal ArticleDOI
Cognitive presentation of multiple sclerosis: evidence for a cortical variant
TL;DR: The neuropsychiatric presentation of multiple sclerosis may represent a clinicopathological entity of “cortical multiple sclerosis” and failure to recognise this will delay diagnosis and may expose patients to potentially dangerous and invasive investigation.
Journal ArticleDOI
Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibility loci
Jacob L. McCauley,Rebecca L. Zuvich,Ashley Beecham,Philip L. De Jager,Ioanna Konidari,Patrice L. Whitehead,Cristin Aubin,Maria Ban,Susan Pobywajlo,Rebeccah Briskin,Susan Romano,Neelum T. Aggarwal,Laura Piccio,Wendy L. McArdle,David P. Strachan,Denis A. Evans,Anne H. Cross,Bruce A.C. Cree,John D. Rioux,Lisa F. Barcellos,Adrian J. Ivinson,Alastair Compston,David A. Hafler,Stephen L. Hauser,Jorge R. Oksenberg,Stephen Sawcer,Margaret A. Pericak-Vance,Jonathan L. Haines +27 more
TL;DR: A substantially more comprehensive follow-up of the first genome-wide association screen performed in multiple sclerosis, a complex genetic disease with central nervous system inflammation, finds considerable evidence for a number of novel susceptibility loci including KIF21B and TMEM39A, both of which meet genome- wide significance.
Journal ArticleDOI
Low-fat, plant-based diet in multiple sclerosis: A randomized controlled trial
Vijayshree Yadav,Vijayshree Yadav,Gail Marracci,Gail Marracci,Edward Kim,Edward Kim,Rebecca I. Spain,Rebecca I. Spain,Michelle Cameron,Michelle Cameron,Shannon Overs,Andrew Riddehough,David K.B. Li,John McDougall,Jesus Lovera,Charles Murchison,Dennis Bourdette,Dennis Bourdette +17 more
TL;DR: The diet intervention resulted in a beneficial effect on the self-reported outcome of fatigue but these results should be interpreted cautiously as a wait-list control group may not completely control for a placebo effect and there was a baseline imbalance on fatigue scores between the groups.
References
More filters
Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Journal ArticleDOI
The clinical course of neuromyelitis optica (Devic's syndrome)
TL;DR: Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS, and patients with relapsing optic neuritis and myelitis may have neuromyeliitis opticas rather than MS.
Journal ArticleDOI
Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis.
George A. Schumacher,Gilbert Beebe,Robert F. Kibler,Leonard T. Kurland,John F. Kurtzke,Fletcher McDowell,Benedict Nagler,William A. Sibley,Wallace W. Tourtellotte,Thomas L. Willmon +9 more
TL;DR: Since its etiology and pathogenesis have eluded detection, it is not surprising that therapeutic attempts have been empiric and often unscientific.
Journal ArticleDOI
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
Frederik Barkhof,Massimo Filippi,David Miller,Philip Scheltens,Adriana Campi,Chris H. Polman,Giancarlo Comi,Herman J. Adèr,N. A. Losseff,Jacob Valk +9 more
TL;DR: It is concluded that a four-parameter dichotomized MRI model including gadolinium-enhancement, juxtacortical, infratentorial and periventricular lesions best predicts conversion to clinically definite multiple sclerosis.
Journal ArticleDOI
MRI in the diagnosis of MS A prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT
Donald W. Paty,Joel Oger,Lorne F. Kastrukoff,S. A. Hashimoto,John P. Hooge,Andrew Eisen,K. A. Eisen,S. J. Purves,M. D. Low,V. Brandejs,W. D. Robertson,David Kb Li +11 more
TL;DR: MRI was the best method for demonstrating dissemination in space and laboratory-supported definite MS (LSDMS) could be diagnosed in 85 patients of the total 200, and MRI predicted that diagnosis in 18/19 (95%).
Related Papers (5)
Rating neurologic impairment in multiple sclerosis An expanded disability status scale (EDSS)
Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria
Chris H. Polman,Stephen C. Reingold,Brenda Banwell,Michel Clanet,Jeffrey A. Cohen,Massimo Filippi,Kazuo Fujihara,Eva Havrdova,Michael Hutchinson,Ludwig Kappos,Fred D. Lublin,Xavier Montalban,Paul L. O’Connor,Magnhild Sandberg-Wollheim,Alan J. Thompson,Emmanuelle Waubant,Brian G. Weinshenker,Jerry S. Wolinsky +17 more