Journal ArticleDOI
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
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TLDR
The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.Abstract:
The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with dinical and other paraclinical diagnostic methods. The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including "monosymptomatic" disease suggestive of MS, disease with a typical relapsing-remitting course, and disease with insidious progression, without clear attacks and remissions. Previously used terms such as "clinically definite" and "probable MS" are no longer recommended. The outcome of a diagnostic evaluation is either MS, "possible MS" (for those at risk for MS, but for whom diagnostic evaluation is equivocal), or "not MS."read more
Citations
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Pregnancy decision-making in women with multiple sclerosis treated with natalizumab: I: Fetal risks
Emilio Portaccio,Pietro Annovazzi,Angelo Ghezzi,Mauro Zaffaroni,Lucia Moiola,Vittorio Martinelli,Roberta Lanzillo,Vincenzo Brescia Morra,Francesca Rinaldi,Paolo Gallo,Carla Tortorella,Damiano Paolicelli,Carlo Pozzilli,Laura De Giglio,Paola Cavalla,Eleonora Cocco,Maria Giovanna Marrosu,Maria Giovanna Marrosu,Francesco Patti,Claudio Solaro,Paolo Bellantonio,Antonio Uccelli,Alice Laroni,Luisa Pastò,Marta Giannini,Maria Trojano,Maria Trojano,Giancarlo Comi,Maria Pia Amato +28 more
TL;DR: It is shown that natalizumab exposure to up 12 weeks of gestation is associated with an increased risk of SA, although within the limits expected in the general population, whereas the risk of CA needs further investigation.
Journal ArticleDOI
Masitinib treatment in patients with progressive multiple sclerosis: a randomized pilot study.
Patrick Vermersch,Rabah Benrabah,Nicolas Schmidt,Hélène Zéphir,Pierre Clavelou,Cyrille Vongsouthi,Patrice Dubreuil,Alain Moussy,Olivier Hermine +8 more
TL;DR: Data suggest that masitinib is of therapeutic benefit to PPMS and rfSPMS patients and could represent an innovative avenue of treatment for this disease, and evidence is provided that may support a larger placebo-controlled investigation.
Journal ArticleDOI
Acute disseminated encephalomyelitis in children: discordant neurologic and neuroimaging abnormalities and response to plasmapheresis.
Divya S. Khurana,Joseph J. Melvin,Sanjeev V. Kothare,Ignacio Valencia,H. Huntley Hardison,Sabrina W. Yum,Eric N. Faerber,Agustin Legido +7 more
TL;DR: Presentation of ADEM with delayed development of MRI lesions in deep gray matter and brainstem may herald a prolonged clinical course and lack of response to glucocorticoid therapy.
Journal ArticleDOI
Markedly increased CSF interleukin-6 levels in neuromyelitis optica, but not in multiple sclerosis.
Akiyuki Uzawa,Masahiro Mori,Michihiro Ito,Tomohiko Uchida,Sei Hayakawa,Saeko Masuda,Satoshi Kuwabara +6 more
TL;DR: Elevated CSF levels of IL-6 in only NMO supports the view of different pathophysiologies of NMO and MS and may be useful in the differential diagnosis of the two disorders.
Journal ArticleDOI
Extensive cortical inflammation is associated with epilepsy in multiple sclerosis.
Massimiliano Calabrese,Nicola De Stefano,M Atzori,Valentina Bernardi,Irene Mattisi,Luigi Barachino,Luciano Rinaldi,Aldo Morra,Matthew M. J. Mcauliffe,Paola Perini,Leontino Battistin,Paolo Gallo +11 more
TL;DR: It is indicated that RRMS/E have more extensive cortical inflammation than RRMS patients with no history of epilepsy, and Inflammatory ICLs may be responsible for epilepsy in MS.
References
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Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Journal ArticleDOI
The clinical course of neuromyelitis optica (Devic's syndrome)
TL;DR: Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS, and patients with relapsing optic neuritis and myelitis may have neuromyeliitis opticas rather than MS.
Journal ArticleDOI
Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis.
George A. Schumacher,Gilbert Beebe,Robert F. Kibler,Leonard T. Kurland,John F. Kurtzke,Fletcher McDowell,Benedict Nagler,William A. Sibley,Wallace W. Tourtellotte,Thomas L. Willmon +9 more
TL;DR: Since its etiology and pathogenesis have eluded detection, it is not surprising that therapeutic attempts have been empiric and often unscientific.
Journal ArticleDOI
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
Frederik Barkhof,Massimo Filippi,David Miller,Philip Scheltens,Adriana Campi,Chris H. Polman,Giancarlo Comi,Herman J. Adèr,N. A. Losseff,Jacob Valk +9 more
TL;DR: It is concluded that a four-parameter dichotomized MRI model including gadolinium-enhancement, juxtacortical, infratentorial and periventricular lesions best predicts conversion to clinically definite multiple sclerosis.
Journal ArticleDOI
MRI in the diagnosis of MS A prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT
Donald W. Paty,Joel Oger,Lorne F. Kastrukoff,S. A. Hashimoto,John P. Hooge,Andrew Eisen,K. A. Eisen,S. J. Purves,M. D. Low,V. Brandejs,W. D. Robertson,David Kb Li +11 more
TL;DR: MRI was the best method for demonstrating dissemination in space and laboratory-supported definite MS (LSDMS) could be diagnosed in 85 patients of the total 200, and MRI predicted that diagnosis in 18/19 (95%).
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