Journal ArticleDOI
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
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TLDR
The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.Abstract:
The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with dinical and other paraclinical diagnostic methods. The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including "monosymptomatic" disease suggestive of MS, disease with a typical relapsing-remitting course, and disease with insidious progression, without clear attacks and remissions. Previously used terms such as "clinically definite" and "probable MS" are no longer recommended. The outcome of a diagnostic evaluation is either MS, "possible MS" (for those at risk for MS, but for whom diagnostic evaluation is equivocal), or "not MS."read more
Citations
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Journal ArticleDOI
Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease
Hervé Perron,Raphaëlle Germi,Corinne Bernard,Marta Garcia-Montojo,Cécile Deluen,Laurent Farinelli,Raphaël Faucard,Francisco Veas,Ilias Stefas,Babs O. Fabriek,Jack Van-Horssen,Paul Van-Der-Valk,Claire Gerdil,Roberta Mancuso,Marina Saresella,Mario Clerici,Sébastien Marcel,Alain Créange,Rosella Cavaretta,Domenico Caputo,Giannina Arru,Patrice Morand,Alois B. Lang,Stefano Sotgiu,Klemens Ruprecht,Peter Rieckmann,Pablo Villoslada,Michel Chofflon,José Boucraut,Jean Pelletier,Hans-Peter Hartung +30 more
TL;DR: The association between MS disease and the MSRV-type HERV-W element now appears quite strong, as evidenced ex-vivo from serum and PBMC with post-mortem confirmation in brain lesions, and amplicon sequencing confirms the association with particular HERv-W elements.
Key issues in the diagnosis and treatment of multiple sclerosis
Paul O'Connor,PubMed Citation +1 more
TL;DR: This review provides a concise, up-to-date overview of key issues relating to MS and its management and discusses the use of MRI as a surrogate measure in MS treatment trials, with commentaries on the specific MRI-oriented publications related to the disease-modifying therapies.
Journal ArticleDOI
The contemporary spectrum of multiple sclerosis misdiagnosis: A multicenter study
Andrew J. Solomon,Dennis Bourdette,Anne H. Cross,Angela Applebee,Philip Skidd,Diantha B. Howard,Rebecca Spain,Michelle Cameron,Edward Kim,Michele Mass,Vijayshree Yadav,Ruth H. Whitham,Erin E. Longbrake,Robert T. Naismith,Gregory F. Wu,Becky J. Parks,Dean M. Wingerchuk,Brian L. Rabin,Michel Toledano,W. Oliver Tobin,Orhun H. Kantarci,Jonathan L. Carter,B. Mark Keegan,Brian G. Weinshenker +23 more
TL;DR: Misdiagnosis of MS leads to unnecessary and potentially harmful risks to patients and leading factors contributing to misdiagnosis were consideration of symptoms atypical for demyelinating disease, lack of corroborative objective evidence of a CNS lesion as satisfying criteria for MS attacks, and overreliance on MRI abnormalities in patients with nonspecific neurologic symptoms.
Journal ArticleDOI
Cerebrospinal fluid antibodies to aquaporin-4 in neuromyelitis optica and related disorders: frequency, origin, and diagnostic relevance
Sven Jarius,Diego Franciotta,Friedemann Paul,Klemens Ruprecht,Roberto Bergamaschi,Paulus S. Rommer,Reinhard Reuss,Christian Probst,Wolfgang Kristoferitsch,Klaus-Peter Wandinger,Brigitte Wildemann +10 more
TL;DR: AQP4-Ab are detectable in the CSF of most patients with NMOSD, mainly during relapse, and are highly specific for this condition, according to the unique localisation of the target antigen at the blood brain barrier.
Journal ArticleDOI
The clinical features, MRI findings, and outcome of optic neuritis in children
TL;DR: Contrary to expectations, optic neuritis in childhood was more likely to be unilateral, multiple sclerosis (MS) risk was high, and bilateral rather than unilateral ON was associated with a greater likelihood of MS.
References
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Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Journal ArticleDOI
The clinical course of neuromyelitis optica (Devic's syndrome)
TL;DR: Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS, and patients with relapsing optic neuritis and myelitis may have neuromyeliitis opticas rather than MS.
Journal ArticleDOI
Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis.
George A. Schumacher,Gilbert Beebe,Robert F. Kibler,Leonard T. Kurland,John F. Kurtzke,Fletcher McDowell,Benedict Nagler,William A. Sibley,Wallace W. Tourtellotte,Thomas L. Willmon +9 more
TL;DR: Since its etiology and pathogenesis have eluded detection, it is not surprising that therapeutic attempts have been empiric and often unscientific.
Journal ArticleDOI
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
Frederik Barkhof,Massimo Filippi,David Miller,Philip Scheltens,Adriana Campi,Chris H. Polman,Giancarlo Comi,Herman J. Adèr,N. A. Losseff,Jacob Valk +9 more
TL;DR: It is concluded that a four-parameter dichotomized MRI model including gadolinium-enhancement, juxtacortical, infratentorial and periventricular lesions best predicts conversion to clinically definite multiple sclerosis.
Journal ArticleDOI
MRI in the diagnosis of MS A prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT
Donald W. Paty,Joel Oger,Lorne F. Kastrukoff,S. A. Hashimoto,John P. Hooge,Andrew Eisen,K. A. Eisen,S. J. Purves,M. D. Low,V. Brandejs,W. D. Robertson,David Kb Li +11 more
TL;DR: MRI was the best method for demonstrating dissemination in space and laboratory-supported definite MS (LSDMS) could be diagnosed in 85 patients of the total 200, and MRI predicted that diagnosis in 18/19 (95%).
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