Journal ArticleDOI
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
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TLDR
The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.Abstract:
The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with dinical and other paraclinical diagnostic methods. The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including "monosymptomatic" disease suggestive of MS, disease with a typical relapsing-remitting course, and disease with insidious progression, without clear attacks and remissions. Previously used terms such as "clinically definite" and "probable MS" are no longer recommended. The outcome of a diagnostic evaluation is either MS, "possible MS" (for those at risk for MS, but for whom diagnostic evaluation is equivocal), or "not MS."read more
Citations
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Diffusion imaging in multiple sclerosis: research and clinical implications
TL;DR: Diffusion weighted MRI is a quantitative technique able to overcome limitations by providing markers more specific to the underlying pathologic substrates and more sensitive to the full extent of ‘occult’ brain tissue damage.
Journal ArticleDOI
CD4 + CD25 + FoxP3 + T lymphocytes fail to suppress myelin basic protein-induced proliferation in patients with multiple sclerosis
Manoj Kumar,Norman Putzki,Volker Limmroth,Ralph Remus,Monika Lindemann,Dietmar Knop,Norbert Mueller,Cornelia Hardt,Ernst Kreuzfelder,Hans Grosse-Wilde +9 more
TL;DR: Impaired T(reg) function may be involved in pathogenesis of MS, and relative T( Reg) counts was significantly increased in MS patients compared with healthy individuals.
Journal ArticleDOI
Cognitive impairment predicts conversion to multiple sclerosis in clinically isolated syndromes.
Valentina Zipoli,Benedetta Goretti,Bahia Hakiki,Gianfranco Siracusa,Sandro Sorbi,Emilio Portaccio,Maria Pia Amato +6 more
TL;DR: It is concluded that cognitive impairment is detectable in a sizable proportion of patients with clinically isolated syndromes and has a prognostic value in predicting conversion to multiple sclerosis and may therefore play a role in therapeutic decision making.
Journal ArticleDOI
Pregnancy and fetal outcomes after interferon-β exposure in multiple sclerosis
Maria Pia Amato,Emilio Portaccio,A. Ghezzi,Bahia Hakiki,Valentina Zipoli,Vittorio Martinelli,Lucia Moiola,Francesco Patti,L. La Mantia,G. L. Mancardi,Claudio Solaro,M. R. Tola,Carlo Pozzilli,L. De Giglio,Rocco Totaro,Alessandra Lugaresi,V. Di Tommaso,Damiano Paolicelli,Maria Giovanna Marrosu,Giancarlo Comi,Fabio Pellegrini,Maria Trojano +21 more
TL;DR: The findings point to the relative safety of IFNβ exposure times of up to 4 weeks and can assist neurologists facing therapeutic decisions in women with MS with a pregnancy plan.
Journal ArticleDOI
Deep gray matter perfusion in multiple sclerosis: dynamic susceptibility contrast perfusion magnetic resonance imaging at 3 T.
Matilde Inglese,Sun-Jung Park,Glyn Johnson,James S. Babb,Laura Miles,Hina Jaggi,Joseph Herbert,Robert I. Grossman +7 more
TL;DR: The decrease of tissue perfusion in the deep gray matter of patients with MS is associated with the severity of fatigue.
References
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Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Journal ArticleDOI
The clinical course of neuromyelitis optica (Devic's syndrome)
TL;DR: Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS, and patients with relapsing optic neuritis and myelitis may have neuromyeliitis opticas rather than MS.
Journal ArticleDOI
Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis.
George A. Schumacher,Gilbert Beebe,Robert F. Kibler,Leonard T. Kurland,John F. Kurtzke,Fletcher McDowell,Benedict Nagler,William A. Sibley,Wallace W. Tourtellotte,Thomas L. Willmon +9 more
TL;DR: Since its etiology and pathogenesis have eluded detection, it is not surprising that therapeutic attempts have been empiric and often unscientific.
Journal ArticleDOI
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
Frederik Barkhof,Massimo Filippi,David Miller,Philip Scheltens,Adriana Campi,Chris H. Polman,Giancarlo Comi,Herman J. Adèr,N. A. Losseff,Jacob Valk +9 more
TL;DR: It is concluded that a four-parameter dichotomized MRI model including gadolinium-enhancement, juxtacortical, infratentorial and periventricular lesions best predicts conversion to clinically definite multiple sclerosis.
Journal ArticleDOI
MRI in the diagnosis of MS A prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT
Donald W. Paty,Joel Oger,Lorne F. Kastrukoff,S. A. Hashimoto,John P. Hooge,Andrew Eisen,K. A. Eisen,S. J. Purves,M. D. Low,V. Brandejs,W. D. Robertson,David Kb Li +11 more
TL;DR: MRI was the best method for demonstrating dissemination in space and laboratory-supported definite MS (LSDMS) could be diagnosed in 85 patients of the total 200, and MRI predicted that diagnosis in 18/19 (95%).
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