Journal ArticleDOI
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
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TLDR
The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.Abstract:
The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with dinical and other paraclinical diagnostic methods. The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including "monosymptomatic" disease suggestive of MS, disease with a typical relapsing-remitting course, and disease with insidious progression, without clear attacks and remissions. Previously used terms such as "clinically definite" and "probable MS" are no longer recommended. The outcome of a diagnostic evaluation is either MS, "possible MS" (for those at risk for MS, but for whom diagnostic evaluation is equivocal), or "not MS."read more
Citations
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Journal ArticleDOI
Impaired social cognition in multiple sclerosis
TL;DR: Impaired social cognition in patients with MS may not simply be a consequence of the well known neuropsychological deficits, and difficulties with correctly identifying emotions, thoughts and intentions in social situations may result in interpersonal problems and could contribute to the psychosocial burden of MS.
Journal ArticleDOI
Relapses and disability accumulation in progressive multiple sclerosis
M. Mateo Paz Soldan,Martina Novotna,Martina Novotna,Nuhad Abou Zeid,Nilufer Kale,Melih Tutuncu,Daniel J. Crusan,Elizabeth J. Atkinson,Aksel Siva,B. Mark Keegan,Istvan Pirko,Sean J. Pittock,Claudia F. Lucchinetti,Brian G. Weinshenker,Moses Rodriguez,Orhun H. Kantarci +15 more
TL;DR: Pre- and postprogression relapses accelerate time to severe disability in progressive MS and continuing immunomodulation for 5 years after the onset of progressive disease or until 55 years of age may be reasonable to consider in patients with BOPMS who have ongoing relapses.
Journal ArticleDOI
A pilot trial of low-dose naltrexone in primary progressive multiple sclerosis.
Maira Gironi,Filippo Martinelli-Boneschi,Paola Sacerdote,Claudio Solaro,Mauro Zaffaroni,Rosella Cavarretta,Lucia Moiola,S. Bucello,Marta Radaelli,V. Pilato,Mariaemma Rodegher,Marco Cursi,Silvia Franchi,Vittorio Martinelli,Raffaello Nemni,Giancarlo Comi,Gianvito Martino +16 more
TL;DR: The data clearly indicate that LDN is safe and well tolerated in patients with PPMS and a significant reduction of spasticity was measured at the end of the trial.
Journal ArticleDOI
Predictive markers for response to interferon therapy in patients with multiple sclerosis.
Simona Malucchi,Francesca Gilli,Marzia Caldano,Fabiana Marnetto,Paola Valentino,Letizia Granieri,Arianna Sala,Marco Capobianco,Antonio Bertolotto +8 more
TL;DR: Findings indicate that measurements of both myxovirus-resistance-protein A (MxA) and neutralizing antibodies (NAbs) predict the risk of new relapses; however, the slightly stronger prognostic significance of MxA mRNA and the easier method for it measurement make MXA mRNA the preferred biomarker for monitoring interferon β (IFNβ)-treated patients.
Journal ArticleDOI
Simple and complex movement‐associated functional MRI changes in patients at presentation with clinically isolated syndromes suggestive of multiple sclerosis
Massimo Filippi,Maria A. Rocca,Domenico M. Mezzapesa,Angelo Ghezzi,Andrea Falini,Vittorio Martinelli,Giuseppe Scotti,Giancarlo Comi +7 more
TL;DR: The comparison of brain activations during the performance of simple vs. complex motor tasks showed that the movement‐associated somatotopic organization of the cerebral and cerebellar cortices was retained in patients with CIS.
References
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Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Journal ArticleDOI
The clinical course of neuromyelitis optica (Devic's syndrome)
TL;DR: Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS, and patients with relapsing optic neuritis and myelitis may have neuromyeliitis opticas rather than MS.
Journal ArticleDOI
Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis.
George A. Schumacher,Gilbert Beebe,Robert F. Kibler,Leonard T. Kurland,John F. Kurtzke,Fletcher McDowell,Benedict Nagler,William A. Sibley,Wallace W. Tourtellotte,Thomas L. Willmon +9 more
TL;DR: Since its etiology and pathogenesis have eluded detection, it is not surprising that therapeutic attempts have been empiric and often unscientific.
Journal ArticleDOI
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
Frederik Barkhof,Massimo Filippi,David Miller,Philip Scheltens,Adriana Campi,Chris H. Polman,Giancarlo Comi,Herman J. Adèr,N. A. Losseff,Jacob Valk +9 more
TL;DR: It is concluded that a four-parameter dichotomized MRI model including gadolinium-enhancement, juxtacortical, infratentorial and periventricular lesions best predicts conversion to clinically definite multiple sclerosis.
Journal ArticleDOI
MRI in the diagnosis of MS A prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT
Donald W. Paty,Joel Oger,Lorne F. Kastrukoff,S. A. Hashimoto,John P. Hooge,Andrew Eisen,K. A. Eisen,S. J. Purves,M. D. Low,V. Brandejs,W. D. Robertson,David Kb Li +11 more
TL;DR: MRI was the best method for demonstrating dissemination in space and laboratory-supported definite MS (LSDMS) could be diagnosed in 85 patients of the total 200, and MRI predicted that diagnosis in 18/19 (95%).
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