Journal ArticleDOI
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
Reads0
Chats0
TLDR
The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.Abstract:
The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with dinical and other paraclinical diagnostic methods. The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including "monosymptomatic" disease suggestive of MS, disease with a typical relapsing-remitting course, and disease with insidious progression, without clear attacks and remissions. Previously used terms such as "clinically definite" and "probable MS" are no longer recommended. The outcome of a diagnostic evaluation is either MS, "possible MS" (for those at risk for MS, but for whom diagnostic evaluation is equivocal), or "not MS."read more
Citations
More filters
Journal ArticleDOI
Pathologic and immunologic profiles of a limited form of neuromyelitis optica with myelitis.
Kaori Yanagawa,Izumi Kawachi,Yasuko Toyoshima,Akio Yokoseki,Musashi Arakawa,Arika Hasegawa,Takui Ito,N. Kojima,Ryoko Koike,Keiko Tanaka,T. Kosaka,C. F. Tan,Akiyoshi Kakita,Koichi Okamoto,Mika Tsujita,Kenji Sakimura,Haruhiko Takahashi,Masatoyo Nishizawa +17 more
TL;DR: In this article, the authors investigated 8 patients with the limited form of NMO with myelitis in comparison with 9 patients with a definite form and found that all patients with limited and definite NMO showed uniform relapsing-remitting courses, with no secondary progressive courses.
Latitudinal variation in incidence and type of first central nervous system demyelinating events | NOVA. The University of Newcastle's Digital Repository
Bruce V. Taylor,Robyn Lucas,Patricia C. Valery,David R. Williams,Anne-Louise Ponsonby,Keith Dear,Trevor J. Kilpatrick,Michael P. Pender,Ingrid van der Mei,Carol Chapman,Alan Coulthard,Terence Dwyer,Anthony J. McMichael +12 more
TL;DR: The latitude-related factor(s) influences FDE incidence variably according to subtype and gender, with the strongest influence on optic neuritis presentations and for males.
Journal ArticleDOI
Vitamin D metabolites are associated with clinical and MRI outcomes in multiple sclerosis patients
Bianca Weinstock-Guttman,Robert Zivadinov,Jun Qu,Diane Cookfair,Xiaotao Duan,Eunjin Bang,Niels Bergsland,Sara Hussein,Mariya Cherneva,Laura Willis,M. Heininen-Brown,Murali Ramanathan +11 more
TL;DR: Vitamin D metabolites have protective associations with disability and brain atrophy in MS, and results indicate strong associations for the 24, 25(OH)2VD3 metabolite, which has not been extensively investigated in MS patients.
Journal ArticleDOI
MGAT5 alters the severity of multiple sclerosis
Boel Brynedal,Jérôme Wojcik,Federica Esposito,V. Debailleul,J. Yaouanq,Filippo Martinelli-Boneschi,Gilles Edan,Giacomo P. Comi,Jan Hillert,Hadi Abderrahim +9 more
TL;DR: Two markers within MGAT5, a gene coding for a glycosylation enzyme, were found to be significantly associated with outcome in the screening as well as in an independent population.
Journal ArticleDOI
Suicidal ideation in multiple sclerosis.
TL;DR: Suicidal ideation is common among VHA patients with MS, and depression severity is the best risk marker, and brief screening for depression in MS should include the assessment of suicidal ideation.
References
More filters
Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Journal ArticleDOI
The clinical course of neuromyelitis optica (Devic's syndrome)
TL;DR: Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS, and patients with relapsing optic neuritis and myelitis may have neuromyeliitis opticas rather than MS.
Journal ArticleDOI
Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis.
George A. Schumacher,Gilbert Beebe,Robert F. Kibler,Leonard T. Kurland,John F. Kurtzke,Fletcher McDowell,Benedict Nagler,William A. Sibley,Wallace W. Tourtellotte,Thomas L. Willmon +9 more
TL;DR: Since its etiology and pathogenesis have eluded detection, it is not surprising that therapeutic attempts have been empiric and often unscientific.
Journal ArticleDOI
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
Frederik Barkhof,Massimo Filippi,David Miller,Philip Scheltens,Adriana Campi,Chris H. Polman,Giancarlo Comi,Herman J. Adèr,N. A. Losseff,Jacob Valk +9 more
TL;DR: It is concluded that a four-parameter dichotomized MRI model including gadolinium-enhancement, juxtacortical, infratentorial and periventricular lesions best predicts conversion to clinically definite multiple sclerosis.
Journal ArticleDOI
MRI in the diagnosis of MS A prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT
Donald W. Paty,Joel Oger,Lorne F. Kastrukoff,S. A. Hashimoto,John P. Hooge,Andrew Eisen,K. A. Eisen,S. J. Purves,M. D. Low,V. Brandejs,W. D. Robertson,David Kb Li +11 more
TL;DR: MRI was the best method for demonstrating dissemination in space and laboratory-supported definite MS (LSDMS) could be diagnosed in 85 patients of the total 200, and MRI predicted that diagnosis in 18/19 (95%).
Related Papers (5)
Rating neurologic impairment in multiple sclerosis An expanded disability status scale (EDSS)
Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria
Chris H. Polman,Stephen C. Reingold,Brenda Banwell,Michel Clanet,Jeffrey A. Cohen,Massimo Filippi,Kazuo Fujihara,Eva Havrdova,Michael Hutchinson,Ludwig Kappos,Fred D. Lublin,Xavier Montalban,Paul L. O’Connor,Magnhild Sandberg-Wollheim,Alan J. Thompson,Emmanuelle Waubant,Brian G. Weinshenker,Jerry S. Wolinsky +17 more