Journal ArticleDOI
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
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TLDR
The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.Abstract:
The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with dinical and other paraclinical diagnostic methods. The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including "monosymptomatic" disease suggestive of MS, disease with a typical relapsing-remitting course, and disease with insidious progression, without clear attacks and remissions. Previously used terms such as "clinically definite" and "probable MS" are no longer recommended. The outcome of a diagnostic evaluation is either MS, "possible MS" (for those at risk for MS, but for whom diagnostic evaluation is equivocal), or "not MS."read more
Citations
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Journal ArticleDOI
Oropharyngeal dysphagia in multiple sclerosis.
Marziyeh Poorjavad,Fatemeh Derakhshandeh,Masoud Etemadifar,Bahram Soleymani,Alireza Minagar,Amir-Hadi Maghzi +5 more
TL;DR: The results emphasize the importance of assessment and management of swallowing function in MS patients, particularly in patients with a high EDSS score; more sever cerebellar dysfunction, and long disease duration.
Journal ArticleDOI
Frequency of blood CX3CR1-positive natural killer cells correlates with disease activity in multiple sclerosis patients.
Carmen Infante-Duarte,Alexandra Weber,Jörn Krätzschmar,Timour Prozorovski,Susan Pikol,Isabell Hamann,Judith Bellmann-Strobl,Orhan Aktas,Jan Dörr,Jens Wuerfel,Claus-Steffen Stürzebecher,Frauke Zipp +11 more
TL;DR: An RNA screen in peripheral mononuclear cells from relapsing‐remitting and primary progressive MS patients compared with healthy donors (HD) indicated a role for the chemokine receptor CX3CR1 as a diagnostic marker, and found a correlation between disease activity and frequency of CX 3CR1‐positive NK cells in RRMS patients.
Journal ArticleDOI
Inflammatory multiple-sclerosis plaques generate characteristic metabolic profiles in cerebrospinal fluid.
Norbert W. Lutz,Angèle Viola,Irina Malikova,Sylviane Confort-Gouny,Bertrand Audoin,Jean-Philippe Ranjeva,Jean Pelletier,Patrick J. Cozzone +7 more
TL;DR: CSF metabolic profiles suggest a close link between MS plaque activity in CIS patients on the one hand and organic-acid metabolism on the other, and increased BHIB levels points to a hitherto unsuspected role for this compound in MS with active plaques.
Journal ArticleDOI
Distinct cognitive impairments in different disease courses of multiple sclerosis-A systematic review and meta-analysis.
Andreas Johnen,Nils C. Landmeyer,Paul-Christian Bürkner,Heinz Wiendl,Sven G. Meuth,Heinz Holling +5 more
TL;DR: Results imply that, previously under‐recognized, PPMS patients display severe degrees of CI and need more specialized disease management than RRMS patients.
Journal ArticleDOI
Acute disseminated encephalomyelitis: a review of 18 cases in childhood.
G Gupte,M Stonehouse,Evangeline Wassmer,N A G Coad,William P Whitehouse,William P Whitehouse +5 more
TL;DR: The present study was initiated to report on the various modes of presentation and raise the awareness of the diagnosis of ADEM among general paediatricians.
References
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Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Journal ArticleDOI
The clinical course of neuromyelitis optica (Devic's syndrome)
TL;DR: Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS, and patients with relapsing optic neuritis and myelitis may have neuromyeliitis opticas rather than MS.
Journal ArticleDOI
Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis.
George A. Schumacher,Gilbert Beebe,Robert F. Kibler,Leonard T. Kurland,John F. Kurtzke,Fletcher McDowell,Benedict Nagler,William A. Sibley,Wallace W. Tourtellotte,Thomas L. Willmon +9 more
TL;DR: Since its etiology and pathogenesis have eluded detection, it is not surprising that therapeutic attempts have been empiric and often unscientific.
Journal ArticleDOI
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
Frederik Barkhof,Massimo Filippi,David Miller,Philip Scheltens,Adriana Campi,Chris H. Polman,Giancarlo Comi,Herman J. Adèr,N. A. Losseff,Jacob Valk +9 more
TL;DR: It is concluded that a four-parameter dichotomized MRI model including gadolinium-enhancement, juxtacortical, infratentorial and periventricular lesions best predicts conversion to clinically definite multiple sclerosis.
Journal ArticleDOI
MRI in the diagnosis of MS A prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT
Donald W. Paty,Joel Oger,Lorne F. Kastrukoff,S. A. Hashimoto,John P. Hooge,Andrew Eisen,K. A. Eisen,S. J. Purves,M. D. Low,V. Brandejs,W. D. Robertson,David Kb Li +11 more
TL;DR: MRI was the best method for demonstrating dissemination in space and laboratory-supported definite MS (LSDMS) could be diagnosed in 85 patients of the total 200, and MRI predicted that diagnosis in 18/19 (95%).
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