Journal ArticleDOI
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
TLDR
The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.Abstract:
The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with dinical and other paraclinical diagnostic methods. The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including "monosymptomatic" disease suggestive of MS, disease with a typical relapsing-remitting course, and disease with insidious progression, without clear attacks and remissions. Previously used terms such as "clinically definite" and "probable MS" are no longer recommended. The outcome of a diagnostic evaluation is either MS, "possible MS" (for those at risk for MS, but for whom diagnostic evaluation is equivocal), or "not MS."read more
Citations
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Journal ArticleDOI
Clinical and radiographic spectrum of pathologically confirmed tumefactive multiple sclerosis
Claudia F. Lucchinetti,R. H. Gavrilova,Imke Metz,Joseph E. Parisi,B. W. Scheithauer,S. Weigand,K. Thomsen,Jay Mandrekar,Ayse Altintas,Bradley J. Erickson,F. König,C. Giannini,Hans Lassmann,L. Linbo,S. J. Pittock,Wolfgang Brück +15 more
TL;DR: Although lesion size >5 cm was associated with a slightly higher EDSS at last follow-up, long-term prognosis in patients with disease duration >10 years was better compared with a population-based multiple sclerosis cohort matched for disease duration (EDSS 3.5; P < 0.001).
Journal ArticleDOI
MS quality of life, depression, and fatigue improve after mindfulness training: A randomized trial
Paul Grossman,Ludwig Kappos,Henrik Gensicke,M. D'Souza,David C. Mohr,Iris-Katharina Penner,C. Steiner +6 more
TL;DR: This trial provides Class III evidence that MBI compared with UC improved HRQOL, fatigue, and depression up to 6 months postintervention and effect sizes were larger than for the total sample.
Journal ArticleDOI
Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis.
Ranjan Dutta,Bruce D. Trapp +1 more
TL;DR: The etiology, mechanisms and progress made in determining the cause of axonal and neuronal loss in MS are discussed, with a focus on the sixth decade of the disease.
Journal ArticleDOI
Defining high, medium and low impact prognostic factors for developing multiple sclerosis
Mar Tintoré,Alex Rovira,Jordi Río,Susana Otero-Romero,Georgina Arrambide,Carmen Tur,Manuel Comabella,Carlos Nos,María Jesús Arévalo,Laura Negrotto,Ingrid Galán,Angela Vidal-Jordana,Joaquín Castilló,Filipe Palavra,Eva Simon,Raquel Mitjana,Cristina Auger,Jaume Sastre-Garriga,Xavier Montalban +18 more
TL;DR: The demographic and topographic characteristics are low-impact prognostic factors, the presence of oligoclonal bands is a medium- impact prognostic factor, and the number of lesions on brain magnetic resonance is a high-impact prediction factor.
Journal ArticleDOI
Retinal nerve fiber layer is associated with brain atrophy in multiple sclerosis
Eliza Gordon-Lipkin,B. Chodkowski,Daniel S. Reich,Seth A. Smith,Mathew Pulicken,Laura J. Balcer,Elliot M. Frohman,Gary Cutter,Peter A. Calabresi +8 more
TL;DR: In multiple sclerosis (MS), retinal nerve fiber layer thickness is associated with brain parenchymal fraction and CSF volume, and quantification of axonal thickness in the retina by optical coherence tomography (OCT) provides concurrent information about MRI brain abnormality in MS.
References
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Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Journal ArticleDOI
The clinical course of neuromyelitis optica (Devic's syndrome)
TL;DR: Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS, and patients with relapsing optic neuritis and myelitis may have neuromyeliitis opticas rather than MS.
Journal ArticleDOI
Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis.
George A. Schumacher,Gilbert Beebe,Robert F. Kibler,Leonard T. Kurland,John F. Kurtzke,Fletcher McDowell,Benedict Nagler,William A. Sibley,Wallace W. Tourtellotte,Thomas L. Willmon +9 more
TL;DR: Since its etiology and pathogenesis have eluded detection, it is not surprising that therapeutic attempts have been empiric and often unscientific.
Journal ArticleDOI
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
Frederik Barkhof,Massimo Filippi,David Miller,Philip Scheltens,Adriana Campi,Chris H. Polman,Giancarlo Comi,Herman J. Adèr,N. A. Losseff,Jacob Valk +9 more
TL;DR: It is concluded that a four-parameter dichotomized MRI model including gadolinium-enhancement, juxtacortical, infratentorial and periventricular lesions best predicts conversion to clinically definite multiple sclerosis.
Journal ArticleDOI
MRI in the diagnosis of MS A prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT
Donald W. Paty,Joel Oger,Lorne F. Kastrukoff,S. A. Hashimoto,John P. Hooge,Andrew Eisen,K. A. Eisen,S. J. Purves,M. D. Low,V. Brandejs,W. D. Robertson,David Kb Li +11 more
TL;DR: MRI was the best method for demonstrating dissemination in space and laboratory-supported definite MS (LSDMS) could be diagnosed in 85 patients of the total 200, and MRI predicted that diagnosis in 18/19 (95%).
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