Journal ArticleDOI
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
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TLDR
The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.Abstract:
The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with dinical and other paraclinical diagnostic methods. The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including "monosymptomatic" disease suggestive of MS, disease with a typical relapsing-remitting course, and disease with insidious progression, without clear attacks and remissions. Previously used terms such as "clinically definite" and "probable MS" are no longer recommended. The outcome of a diagnostic evaluation is either MS, "possible MS" (for those at risk for MS, but for whom diagnostic evaluation is equivocal), or "not MS."read more
Citations
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The effect of exercise on depressive symptoms in multiple sclerosis based on a meta-analysis and critical review of the literature.
TL;DR: A systematic review of the literature on the effects of exercise on depressive symptoms in patients with multiple sclerosis and meta‐analytical procedures to the results were applied.
Journal ArticleDOI
Sodium intake and multiple sclerosis activity and progression in BENEFIT.
Kathryn C. Fitzgerald,Kassandra L. Munger,Hans-Peter Hartung,Mark S. Freedman,Xavier Montalban,Gilles Edan,Eva-Maria Wicklein,Ernst-Wilhelm Radue,Ludwig Kappos,Christoph Pohl,Alberto Ascherio +10 more
TL;DR: To assess whether a high‐salt diet, as measured by urinary sodium concentration, is associated with faster conversion from clinically isolated syndrome to multiple sclerosis (MS) and MS activity and disability, urine sodium concentration is measured.
Prostaglandins, Leukotrienes and Essential Fatty Acids
Gunveen Kaur,Andrew J. Sinclair,David Cameron-Smith,Daniel P. Barr,Juan C. Molero-Navajas,Nicky Konstantopoulos +5 more
TL;DR: It is suggested that the presence of 20:3n-9 in cartilage may be related to its vesselfree status and that it may be useful for the treatment of disorders with excessive vasculature.
Journal ArticleDOI
MicroRNA regulate immune pathways in T-cells in multiple sclerosis (MS)
Margareta Jernås,Clas Malmeström,Markus Axelsson,Intawat Nookaew,Hans Wadenvik,Jan Lycke,Bob Olsson +6 more
TL;DR: Findings indicate that microRNA may be important regulatory molecules in T-cells in MS, many of which were involved in the immune system.
Journal ArticleDOI
Premorbid cognitive leisure independently contributes to cognitive reserve in multiple sclerosis
TL;DR: Patients with MS who engaged in more cognitive leisure were able to withstand more severe brain atrophy at a given cognitive status, and premorbid cognitive leisure is supported as an independent source of cognitive reserve in patients with MS.
References
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Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Journal ArticleDOI
The clinical course of neuromyelitis optica (Devic's syndrome)
TL;DR: Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS, and patients with relapsing optic neuritis and myelitis may have neuromyeliitis opticas rather than MS.
Journal ArticleDOI
Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis.
George A. Schumacher,Gilbert Beebe,Robert F. Kibler,Leonard T. Kurland,John F. Kurtzke,Fletcher McDowell,Benedict Nagler,William A. Sibley,Wallace W. Tourtellotte,Thomas L. Willmon +9 more
TL;DR: Since its etiology and pathogenesis have eluded detection, it is not surprising that therapeutic attempts have been empiric and often unscientific.
Journal ArticleDOI
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
Frederik Barkhof,Massimo Filippi,David Miller,Philip Scheltens,Adriana Campi,Chris H. Polman,Giancarlo Comi,Herman J. Adèr,N. A. Losseff,Jacob Valk +9 more
TL;DR: It is concluded that a four-parameter dichotomized MRI model including gadolinium-enhancement, juxtacortical, infratentorial and periventricular lesions best predicts conversion to clinically definite multiple sclerosis.
Journal ArticleDOI
MRI in the diagnosis of MS A prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT
Donald W. Paty,Joel Oger,Lorne F. Kastrukoff,S. A. Hashimoto,John P. Hooge,Andrew Eisen,K. A. Eisen,S. J. Purves,M. D. Low,V. Brandejs,W. D. Robertson,David Kb Li +11 more
TL;DR: MRI was the best method for demonstrating dissemination in space and laboratory-supported definite MS (LSDMS) could be diagnosed in 85 patients of the total 200, and MRI predicted that diagnosis in 18/19 (95%).
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