Journal ArticleDOI
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
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TLDR
The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.Abstract:
The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with dinical and other paraclinical diagnostic methods. The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including "monosymptomatic" disease suggestive of MS, disease with a typical relapsing-remitting course, and disease with insidious progression, without clear attacks and remissions. Previously used terms such as "clinically definite" and "probable MS" are no longer recommended. The outcome of a diagnostic evaluation is either MS, "possible MS" (for those at risk for MS, but for whom diagnostic evaluation is equivocal), or "not MS."read more
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Free immunoglobulin light chain: its biology and implications in diseases.
Takanari Nakano,Masanori Matsui,Ikuo Inoue,Takuya Awata,Shigehiro Katayama,Takayuki Murakoshi +5 more
TL;DR: This review attempts to give a comprehensive view about the biological roles of free IgLC together with the gene expression, secretion, antigen-binding ability, and its metabolic characteristics.
Journal ArticleDOI
Microarray analysis identifies interferon β-regulated genes in multiple sclerosis
Fumiko Koike,Jun-ichi Satoh,Sachiko Miyake,Toshiyuki Yamamoto,Mitsuru Kawai,Seiji Kikuchi,K. Nomura,Kazumasa Yokoyama,Kohei Ota,Takashi Kanda,Toshiyuki Fukazawa,Takashi Yamamura +11 more
TL;DR: Using cDNA microarray technology, this work has compared the gene expression profile of T and non-T cells derived from relapsing-remitting MS before and after treatment with IFNbeta-1b, finding some of the changes were unexpected but coincided with the beneficial effect of IFN beta in MS.
Journal ArticleDOI
Muscular and Gait Abnormalities in Persons With Early Onset Multiple Sclerosis
TL;DR: At this early stage of clinically isolated syndrome, evidence of a reduction in lower limb motor performance can already be identified and the possibility of early identification and potential for developing an intervention program that may alter treatment outcome warrants further exploration.
Journal ArticleDOI
Robot-assisted gait training in multiple sclerosis patients: a randomized trial:
Isabella Schwartz,Anna Sajin,Elior Moreh,Iris Fisher,Martin Neeb,Adina Forest,Adi Vaknin-Dembinsky,Dimitrios Karusis,Zeev Meiner +8 more
TL;DR: Robotic-assisted gait training is feasible and safe and may be an effective additional therapeutic option in MS patients with severe walking disabilities.
Journal ArticleDOI
Increased functional connectivity within memory networks following memory rehabilitation in multiple sclerosis
Victoria M. Leavitt,Victoria M. Leavitt,Glenn R. Wylie,Glenn R. Wylie,Peter A. Girgis,John DeLuca,John DeLuca,Nancy D. Chiaravalloti,Nancy D. Chiaravalloti +8 more
TL;DR: Results represent the first evidence for efficacy of a behavioral intervention to impact the integrity of neural networks subserving memory functions in persons with MS.
References
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Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Journal ArticleDOI
The clinical course of neuromyelitis optica (Devic's syndrome)
TL;DR: Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS, and patients with relapsing optic neuritis and myelitis may have neuromyeliitis opticas rather than MS.
Journal ArticleDOI
Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis.
George A. Schumacher,Gilbert Beebe,Robert F. Kibler,Leonard T. Kurland,John F. Kurtzke,Fletcher McDowell,Benedict Nagler,William A. Sibley,Wallace W. Tourtellotte,Thomas L. Willmon +9 more
TL;DR: Since its etiology and pathogenesis have eluded detection, it is not surprising that therapeutic attempts have been empiric and often unscientific.
Journal ArticleDOI
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
Frederik Barkhof,Massimo Filippi,David Miller,Philip Scheltens,Adriana Campi,Chris H. Polman,Giancarlo Comi,Herman J. Adèr,N. A. Losseff,Jacob Valk +9 more
TL;DR: It is concluded that a four-parameter dichotomized MRI model including gadolinium-enhancement, juxtacortical, infratentorial and periventricular lesions best predicts conversion to clinically definite multiple sclerosis.
Journal ArticleDOI
MRI in the diagnosis of MS A prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT
Donald W. Paty,Joel Oger,Lorne F. Kastrukoff,S. A. Hashimoto,John P. Hooge,Andrew Eisen,K. A. Eisen,S. J. Purves,M. D. Low,V. Brandejs,W. D. Robertson,David Kb Li +11 more
TL;DR: MRI was the best method for demonstrating dissemination in space and laboratory-supported definite MS (LSDMS) could be diagnosed in 85 patients of the total 200, and MRI predicted that diagnosis in 18/19 (95%).
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