Journal ArticleDOI
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
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TLDR
The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.Abstract:
The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with dinical and other paraclinical diagnostic methods. The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including "monosymptomatic" disease suggestive of MS, disease with a typical relapsing-remitting course, and disease with insidious progression, without clear attacks and remissions. Previously used terms such as "clinically definite" and "probable MS" are no longer recommended. The outcome of a diagnostic evaluation is either MS, "possible MS" (for those at risk for MS, but for whom diagnostic evaluation is equivocal), or "not MS."read more
Citations
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Constraint-induced movement therapy.
TL;DR: A case report of a patient with upper-extremity hemiparesis due to a stroke who received constraint-induced movement therapy and the Wolf Motor Function Test and the Motor Activity Log were applied to assess the effect of the treatment.
Journal ArticleDOI
Effects of immunomodulatory treatment with subcutaneous interferon beta-1a oncognitive decline in mildly disabled patients with relapsing—remitting multiple sclerosis:
Francesco Patti,Maria Pia Amato,Stefano Bastianello,Luisa Caniatti,E. Di Monte,P Ferrazza,Benedetta Goretti,Paolo Gallo,V. Brescia Morra,S. Lo Fermo,Orietta Picconi,Maria Trojano +11 more
TL;DR: It is suggested that sc IFNβ-1a may have dose-dependent cognitive benefits in mildly disabled patients with relapsing—remitting multiple sclerosis, and may support early initiation of high-dose IFN β- 1a treatment.
Journal ArticleDOI
MRI in the diagnosis and management of multiple sclerosis
TL;DR: MRI techniques, including conventional T2-weighted and gadolinium (Gd)-enhanced T1- Weighted images, have provided important insights into the pathophysiology of MS.
Journal ArticleDOI
Poor early relapse recovery affects onset of progressive disease course in multiple sclerosis
Martina Novotna,Martina Novotna,M. Mateo Paz Soldan,Nuhad Abou Zeid,Nilufer Kale,Melih Tutuncu,Daniel J. Crusan,Elizabeth J. Atkinson,Aksel Siva,B. Mark Keegan,Istvan Pirko,Sean J. Pittock,Claudia F. Lucchinetti,John H. Noseworthy,Brian G. Weinshenker,Moses Rodriguez,Orhun H. Kantarci +16 more
TL;DR: Patients with MS with poor recovery from early relapses will develop progressive disease course earlier than those with good recovery, and initial relapse recovery on time to progressive MS onset was associated with delay in progressive disease onset.
Journal ArticleDOI
Magnetic resonance evidence of cortical onset of multiple sclerosis
TL;DR: It is suggested that, at least in some patients with MS, the pathological process underlying MS starts in the cortex, and DIR sequence should be included in the MRI examination of suspected patients withMS with normal conventional MRI sequences at clinical onset.
References
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Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Journal ArticleDOI
The clinical course of neuromyelitis optica (Devic's syndrome)
TL;DR: Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS, and patients with relapsing optic neuritis and myelitis may have neuromyeliitis opticas rather than MS.
Journal ArticleDOI
Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis.
George A. Schumacher,Gilbert Beebe,Robert F. Kibler,Leonard T. Kurland,John F. Kurtzke,Fletcher McDowell,Benedict Nagler,William A. Sibley,Wallace W. Tourtellotte,Thomas L. Willmon +9 more
TL;DR: Since its etiology and pathogenesis have eluded detection, it is not surprising that therapeutic attempts have been empiric and often unscientific.
Journal ArticleDOI
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
Frederik Barkhof,Massimo Filippi,David Miller,Philip Scheltens,Adriana Campi,Chris H. Polman,Giancarlo Comi,Herman J. Adèr,N. A. Losseff,Jacob Valk +9 more
TL;DR: It is concluded that a four-parameter dichotomized MRI model including gadolinium-enhancement, juxtacortical, infratentorial and periventricular lesions best predicts conversion to clinically definite multiple sclerosis.
Journal ArticleDOI
MRI in the diagnosis of MS A prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT
Donald W. Paty,Joel Oger,Lorne F. Kastrukoff,S. A. Hashimoto,John P. Hooge,Andrew Eisen,K. A. Eisen,S. J. Purves,M. D. Low,V. Brandejs,W. D. Robertson,David Kb Li +11 more
TL;DR: MRI was the best method for demonstrating dissemination in space and laboratory-supported definite MS (LSDMS) could be diagnosed in 85 patients of the total 200, and MRI predicted that diagnosis in 18/19 (95%).
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