Journal ArticleDOI
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
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TLDR
The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.Abstract:
The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with dinical and other paraclinical diagnostic methods. The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including "monosymptomatic" disease suggestive of MS, disease with a typical relapsing-remitting course, and disease with insidious progression, without clear attacks and remissions. Previously used terms such as "clinically definite" and "probable MS" are no longer recommended. The outcome of a diagnostic evaluation is either MS, "possible MS" (for those at risk for MS, but for whom diagnostic evaluation is equivocal), or "not MS."read more
Citations
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MRI T2 hypointensity of the dentate nucleus is related to ambulatory impairment in multiple sclerosis
Christopher W. Tjoa,Ralph H.B. Benedict,Bianca Weinstock-Guttman,Andrew J. Fabiano,Rohit Bakshi +4 more
TL;DR: This study adds more weight to the notion that T2 hypointensity is a clinically relevant marker of tissue damage in MS, as it is present in subcortical gray matter nuclei in patients with MS and normal controls.
Journal ArticleDOI
Abrogation of T cell quiescence characterizes patients at high risk for multiple sclerosis after the initial neurological event
Jean-Christophe Corvol,Daniel Pelletier,Roland G. Henry,Stacy J. Caillier,Joanne Wang,Derek J. Pappas,Simona Casazza,Darin T. Okuda,Stephen L. Hauser,Jorge R. Oksenberg,Sergio E. Baranzini +10 more
TL;DR: It is indicated that CIS patients at high risk of conversion have impaired regulation of T cell quiescence, possibly resulting in earlier activation of pathogenic CD4+ cells.
Journal ArticleDOI
Natalizumab alters transcriptional expression profiles of blood cell subpopulations of multiple sclerosis patients.
TL;DR: Not only gene expression relevant for T lymphocytes was altered, but also genes regulating B-lymphocyte, neutrophil and erythrocyte functions will provide more insights into additional mechanisms of action of natalizumab and possibly allow better prediction of adverse events.
Journal ArticleDOI
Multiple sclerosis susceptibility alleles in African Americans
Britt A. Johnson,J. Wang,E. M. Taylor,Stacy J. Caillier,Joseph Herbert,Omar Khan,Anne H. Cross,P. L. De Jager,P. L. De Jager,Pierre-Antoine Gourraud,Bruce C.A. Cree,Stephen L. Hauser,Jorge R. Oksenberg +12 more
TL;DR: The results are consistent with shared disease genetic mechanisms among individuals of European and African ancestry and none of the tested variants showed results that were statistically inconsistent with the effects established in whites.
Journal ArticleDOI
Vestibular evoked myogenic potentials in multiple sclerosis patients.
Maurizio Versino,Silvia Colnaghi,R. Callieco,Roberto Bergamaschi,Alfredo Romani,Vittorio Cosi +5 more
TL;DR: VEMPs should be considered a useful complementary neurophysiological tool for the evaluation of brainstem dysfunction in patients suffering from multiple sclerosis.
References
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Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Journal ArticleDOI
The clinical course of neuromyelitis optica (Devic's syndrome)
TL;DR: Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS, and patients with relapsing optic neuritis and myelitis may have neuromyeliitis opticas rather than MS.
Journal ArticleDOI
Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis.
George A. Schumacher,Gilbert Beebe,Robert F. Kibler,Leonard T. Kurland,John F. Kurtzke,Fletcher McDowell,Benedict Nagler,William A. Sibley,Wallace W. Tourtellotte,Thomas L. Willmon +9 more
TL;DR: Since its etiology and pathogenesis have eluded detection, it is not surprising that therapeutic attempts have been empiric and often unscientific.
Journal ArticleDOI
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
Frederik Barkhof,Massimo Filippi,David Miller,Philip Scheltens,Adriana Campi,Chris H. Polman,Giancarlo Comi,Herman J. Adèr,N. A. Losseff,Jacob Valk +9 more
TL;DR: It is concluded that a four-parameter dichotomized MRI model including gadolinium-enhancement, juxtacortical, infratentorial and periventricular lesions best predicts conversion to clinically definite multiple sclerosis.
Journal ArticleDOI
MRI in the diagnosis of MS A prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT
Donald W. Paty,Joel Oger,Lorne F. Kastrukoff,S. A. Hashimoto,John P. Hooge,Andrew Eisen,K. A. Eisen,S. J. Purves,M. D. Low,V. Brandejs,W. D. Robertson,David Kb Li +11 more
TL;DR: MRI was the best method for demonstrating dissemination in space and laboratory-supported definite MS (LSDMS) could be diagnosed in 85 patients of the total 200, and MRI predicted that diagnosis in 18/19 (95%).
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