Journal ArticleDOI
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
TLDR
The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.Abstract:
The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with dinical and other paraclinical diagnostic methods. The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including "monosymptomatic" disease suggestive of MS, disease with a typical relapsing-remitting course, and disease with insidious progression, without clear attacks and remissions. Previously used terms such as "clinically definite" and "probable MS" are no longer recommended. The outcome of a diagnostic evaluation is either MS, "possible MS" (for those at risk for MS, but for whom diagnostic evaluation is equivocal), or "not MS."read more
Citations
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Journal ArticleDOI
Spinal cord lesions: A modest contributor to diagnosis in clinically isolated syndromes but a relevant prognostic factor.
Georgina Arrambide,Alex Rovira,Jaume Sastre-Garriga,Carmen Tur,Joaquín Castilló,Jordi Río,Angela Vidal-Jordana,Ingrid Galán,Breogán Rodríguez-Acevedo,Luciana Midaglia,Carlos Nos,Patricia Mulero,María Jesús Arévalo,Manuel Comabella,E. Huerga,Cristina Auger,Xavier Montalban,Mar Tintoré +17 more
TL;DR: SC lesions were very specific for evolution to MS and showed very high sensitivity for EDSS ≥3.0 and contribute to short-term disability accrual.
Journal ArticleDOI
Men transmit MS more often to their children vs women: the Carter effect.
Orhun H. Kantarci,Lisa F. Barcellos,Lisa F. Barcellos,Lisa F. Barcellos,Elizabeth J. Atkinson,Patricia P. Ramsay,Robin R. Lincoln,Sara J. Achenbach,M. De Andrade,Stephen L. Hauser,Brian G. Weinshenker +10 more
TL;DR: The authors have demonstrated the Carter effect in multiple sclerosis (MS), which may be explained by greater genetic loading in men that leads to relative excess paternal vs maternal transmission.
Journal ArticleDOI
Diagnostic change 10 years after a first episode of psychosis.
Margaret Heslin,Ben Lomas,Julia Lappin,Kim Donoghue,Ulrich Reininghaus,Adanna Onyejiaka,Tim Croudace,Peter B. Jones,Robin M. Murray,Paul Fearon,Paola Dazzan,Craig Morgan,Gillian A. Doody +12 more
TL;DR: The diagnostic stability of psychosis diagnoses using data from an incidence sample of psychosis cases, followed up after 10 years and to examine those baseline variables which were associated with diagnostic change was examined to find diagnoses other than schizophrenia should be regarded as potentially provisional.
Journal ArticleDOI
Recombinant interferon beta or glatiramer acetate for delaying conversion of the first demyelinating event to multiple sclerosis.
TL;DR: The efficacy of IFN beta treatment on preventing the conversion from CIS to CDMS was confirmed over two years of follow-up, and side effects were reported with some heterogeneity in the three studies the metanalysis was possible only for the frequency of serious adverse events.
Journal ArticleDOI
Multiple Sclerosis Lesions and Irreversible Brain Tissue Damage: A Comparative Ultrahigh-Field Strength Magnetic Resonance Imaging Study
Tim Sinnecker,Paul Mittelstaedt,Jan Dörr,Caspar F. Pfueller,Lutz Harms,Thoralf Niendorf,Friedemann Paul,Jens Wuerfel +7 more
TL;DR: At ultrahigh-field strength, T1-weighted MPRAGE is highly sensitive in detecting MS plaques within the white and the gray brain parenchyma and indicates structural damage beyond demyelination in every lesion depicted, which is in accordance with postmortem histopathological studies.
References
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Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Journal ArticleDOI
The clinical course of neuromyelitis optica (Devic's syndrome)
TL;DR: Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS, and patients with relapsing optic neuritis and myelitis may have neuromyeliitis opticas rather than MS.
Journal ArticleDOI
Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis.
George A. Schumacher,Gilbert Beebe,Robert F. Kibler,Leonard T. Kurland,John F. Kurtzke,Fletcher McDowell,Benedict Nagler,William A. Sibley,Wallace W. Tourtellotte,Thomas L. Willmon +9 more
TL;DR: Since its etiology and pathogenesis have eluded detection, it is not surprising that therapeutic attempts have been empiric and often unscientific.
Journal ArticleDOI
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
Frederik Barkhof,Massimo Filippi,David Miller,Philip Scheltens,Adriana Campi,Chris H. Polman,Giancarlo Comi,Herman J. Adèr,N. A. Losseff,Jacob Valk +9 more
TL;DR: It is concluded that a four-parameter dichotomized MRI model including gadolinium-enhancement, juxtacortical, infratentorial and periventricular lesions best predicts conversion to clinically definite multiple sclerosis.
Journal ArticleDOI
MRI in the diagnosis of MS A prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT
Donald W. Paty,Joel Oger,Lorne F. Kastrukoff,S. A. Hashimoto,John P. Hooge,Andrew Eisen,K. A. Eisen,S. J. Purves,M. D. Low,V. Brandejs,W. D. Robertson,David Kb Li +11 more
TL;DR: MRI was the best method for demonstrating dissemination in space and laboratory-supported definite MS (LSDMS) could be diagnosed in 85 patients of the total 200, and MRI predicted that diagnosis in 18/19 (95%).
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