Journal ArticleDOI
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
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TLDR
The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.Abstract:
The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with dinical and other paraclinical diagnostic methods. The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including "monosymptomatic" disease suggestive of MS, disease with a typical relapsing-remitting course, and disease with insidious progression, without clear attacks and remissions. Previously used terms such as "clinically definite" and "probable MS" are no longer recommended. The outcome of a diagnostic evaluation is either MS, "possible MS" (for those at risk for MS, but for whom diagnostic evaluation is equivocal), or "not MS."read more
Citations
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Journal ArticleDOI
Magnetic resonance imaging characteristics of children and adults with paediatric-onset multiple sclerosis
E. A. Yeh,Bianca Weinstock-Guttman,Murali Ramanathan,Deepa P. Ramasamy,Laura Willis,Jennifer L. Cox,Robert Zivadinov +6 more
TL;DR: Paediatric-onset multiple sclerosis is characterized by a significant disease burden both early and later in the disease course, and disability is slower to accrue in paediatric onsetmultiple sclerosis than adult onset multiple sclerosis.
Journal ArticleDOI
Correlation between fatigue and brain atrophy and lesion load in multiple sclerosis patients independent of disability
Gioacchino Tedeschi,D. Dinacci,Luigi Lavorgna,Anna Prinster,Giovanni Savettieri,A. Quattrone,P. Livrea,Corrado Messina,Arturo Reggio,G. Servillo,Vincenzo Bresciamorra,Giuseppe Orefice,M. Paciello,Arturo Brunetti,Arturo Brunetti,Andrea Paolillo,G. Coniglio,S. Bonavita,Alfonso Di Costanzo,A. Bellacosa,Paola Valentino,Mario Quarantelli,Francesco Patti,Giuseppe Salemi,Enrico Cammarata,Isabella Laura Simone,Marco Salvatore,Marco Salvatore,Vincenzo Bonavita,Bruno Alfano +29 more
TL;DR: The results suggest that among MS patients with low disability those with high-fatigue show higher WM and GM atrophy and higher lesion load, and that female sex and higher levels of education may play a protective role towards fatigue.
Journal ArticleDOI
Multiple sclerosis in Iran: a demographic study of 8,000 patients and changes over time.
Mohammad Ali Sahraian,Saeideh Khorramnia,Mina Mohammad Ebrahim,Zahra Moinfar,Jamshid Lotfi,Hossien Pakdaman +5 more
TL;DR: The prevalence of MS has increased to a medium-to-high risk level in Iran and the mean age of onset was similar to other studies but the calculated prevalence of early onset MS was increased.
Journal ArticleDOI
Multimodal evoked potentials to assess the evolution of multiple sclerosis: a longitudinal study.
Letizia Leocani,Marco Rovaris,Filippo Martinelli Boneschi,Stefania Medaglini,Paolo Rossi,Vittorio Martinelli,Stefano Amadio,Giancarlo Comi +7 more
TL;DR: The results suggest that evoked potential is a good marker of the severity of nervous damage in multiple sclerosis and may have a predictive value regarding the evolution of disability.
Journal ArticleDOI
MRI evidence for multiple sclerosis as a diffuse disease of the central nervous system.
Massimo Filippi,Maria A. Rocca +1 more
TL;DR: The classical view of MS as a chronic inflammatory demyelinating disease leading to the formation of focal central nervous system (CNS) white matter (WM) lesions has been recently challenged by pathological studies and by the extensive application of modern MRI-based techniques.
References
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Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Journal ArticleDOI
The clinical course of neuromyelitis optica (Devic's syndrome)
TL;DR: Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS, and patients with relapsing optic neuritis and myelitis may have neuromyeliitis opticas rather than MS.
Journal ArticleDOI
Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis.
George A. Schumacher,Gilbert Beebe,Robert F. Kibler,Leonard T. Kurland,John F. Kurtzke,Fletcher McDowell,Benedict Nagler,William A. Sibley,Wallace W. Tourtellotte,Thomas L. Willmon +9 more
TL;DR: Since its etiology and pathogenesis have eluded detection, it is not surprising that therapeutic attempts have been empiric and often unscientific.
Journal ArticleDOI
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
Frederik Barkhof,Massimo Filippi,David Miller,Philip Scheltens,Adriana Campi,Chris H. Polman,Giancarlo Comi,Herman J. Adèr,N. A. Losseff,Jacob Valk +9 more
TL;DR: It is concluded that a four-parameter dichotomized MRI model including gadolinium-enhancement, juxtacortical, infratentorial and periventricular lesions best predicts conversion to clinically definite multiple sclerosis.
Journal ArticleDOI
MRI in the diagnosis of MS A prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT
Donald W. Paty,Joel Oger,Lorne F. Kastrukoff,S. A. Hashimoto,John P. Hooge,Andrew Eisen,K. A. Eisen,S. J. Purves,M. D. Low,V. Brandejs,W. D. Robertson,David Kb Li +11 more
TL;DR: MRI was the best method for demonstrating dissemination in space and laboratory-supported definite MS (LSDMS) could be diagnosed in 85 patients of the total 200, and MRI predicted that diagnosis in 18/19 (95%).
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