Journal ArticleDOI
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
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TLDR
The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.Abstract:
The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with dinical and other paraclinical diagnostic methods. The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including "monosymptomatic" disease suggestive of MS, disease with a typical relapsing-remitting course, and disease with insidious progression, without clear attacks and remissions. Previously used terms such as "clinically definite" and "probable MS" are no longer recommended. The outcome of a diagnostic evaluation is either MS, "possible MS" (for those at risk for MS, but for whom diagnostic evaluation is equivocal), or "not MS."read more
Citations
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Journal ArticleDOI
Interferon beta-induced restoration of regulatory T-cell function in multiple sclerosis is prompted by an increase in newly generated naive regulatory T cells.
Mirjam Korporal,Juergen Haas,Bettina Balint,Benedikt Fritzsching,Alexander Schwarz,Sigrid Moeller,Brigitte Fritz,Elisabeth Suri-Payer,Brigitte Wildemann +8 more
TL;DR: The increase in T(Reg)-cell inhibitory capacity mediated by interferon beta treatment can be explained by its effect on the homeostatic balance within the T(reg) cell compartment.
Journal ArticleDOI
Interferon-β and serum 25-hydroxyvitamin D interact to modulate relapse risk in MS
Niall Stewart,Steve Simpson,Ingrid van der Mei,Anne-Louise Ponsonby,Leigh Blizzard,T Dwyer,Fotini Pittas,Darryl W. Eyles,Pauline Ko,Bruce V. Taylor +9 more
TL;DR: Findings suggest persons being treated with IFN-β should have vitamin D status monitored and maintained in the sufficiency range, suggesting part of the therapeutic effects of IFn-β on relapse in MS may be through modulation of vitamin D metabolism.
Journal ArticleDOI
Voxel-based analysis of MTR images: a method to locate gray matter abnormalities in patients at the earliest stage of multiple sclerosis.
Bertrand Audoin,Jean-Philippe Ranjeva,My Van Au Duong,Danielle Ibarrola,Irina Malikova,Sylviane Confort-Gouny,Elisabeth Soulier,Patrick Viout,André Ali-Chérif,Jean Pelletier,Patrick J. Cozzone +10 more
TL;DR: To determine whether voxel‐based analysis of magnetization transfer ratio (MTR) maps can provide evidence of a coherent pattern of gray matter (GM) macroscopic and microscopic tissue damage in patients at the earliest stage of multiple sclerosis (MS),
Journal ArticleDOI
Latitudinal variation in incidence and type of first central nervous system demyelinating events
Bruce V. Taylor,Robyn M. Lucas,Keith Dear,Trevor J. Kilpatrick,Michael P. Pender,Ingrid van der Mei,C. Chapman,Alan Coulthard,Terence Dwyer,Anthony J. McMichael,Patricia C. Valery,David Williams,Anne-Louise Ponsonby +12 more
TL;DR: For instance, the authors found that the incidence rate of first demyelinating events (FDEs) increased by 9.55% (95% confidence interval (CI) 7.37-11.78, p < 0.001) per higher degree of latitude.
Journal ArticleDOI
Interferon beta for secondary progressive multiple sclerosis
Loredana La Mantia,Laura Vacchi,Carlo Di Pietrantonj,George C. Ebers,Marco Rovaris,Sten Fredrikson,Graziella Filippini +6 more
TL;DR: Results show that IFNs' anti-inflammatory effect is unable to retard progression, when established, and no new RCTs for IFNs versus placebo in SPMS will probably be undertaken, because research is now focusing on innovative drugs.
References
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Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Journal ArticleDOI
The clinical course of neuromyelitis optica (Devic's syndrome)
TL;DR: Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS, and patients with relapsing optic neuritis and myelitis may have neuromyeliitis opticas rather than MS.
Journal ArticleDOI
Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis.
George A. Schumacher,Gilbert Beebe,Robert F. Kibler,Leonard T. Kurland,John F. Kurtzke,Fletcher McDowell,Benedict Nagler,William A. Sibley,Wallace W. Tourtellotte,Thomas L. Willmon +9 more
TL;DR: Since its etiology and pathogenesis have eluded detection, it is not surprising that therapeutic attempts have been empiric and often unscientific.
Journal ArticleDOI
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
Frederik Barkhof,Massimo Filippi,David Miller,Philip Scheltens,Adriana Campi,Chris H. Polman,Giancarlo Comi,Herman J. Adèr,N. A. Losseff,Jacob Valk +9 more
TL;DR: It is concluded that a four-parameter dichotomized MRI model including gadolinium-enhancement, juxtacortical, infratentorial and periventricular lesions best predicts conversion to clinically definite multiple sclerosis.
Journal ArticleDOI
MRI in the diagnosis of MS A prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT
Donald W. Paty,Joel Oger,Lorne F. Kastrukoff,S. A. Hashimoto,John P. Hooge,Andrew Eisen,K. A. Eisen,S. J. Purves,M. D. Low,V. Brandejs,W. D. Robertson,David Kb Li +11 more
TL;DR: MRI was the best method for demonstrating dissemination in space and laboratory-supported definite MS (LSDMS) could be diagnosed in 85 patients of the total 200, and MRI predicted that diagnosis in 18/19 (95%).
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