Journal ArticleDOI
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
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TLDR
The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.Abstract:
The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with dinical and other paraclinical diagnostic methods. The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including "monosymptomatic" disease suggestive of MS, disease with a typical relapsing-remitting course, and disease with insidious progression, without clear attacks and remissions. Previously used terms such as "clinically definite" and "probable MS" are no longer recommended. The outcome of a diagnostic evaluation is either MS, "possible MS" (for those at risk for MS, but for whom diagnostic evaluation is equivocal), or "not MS."read more
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Journal ArticleDOI
Spinal cord abnormalities in recently diagnosed MS patients: added value of spinal MRI examination.
Joost C.J. Bot,Frederik Barkhof,Chris H. Polman,G. J. Lycklama à Nijeholt,V. de Groot,E. Bergers,Herman J. Adèr,Jonas A. Castelijns +7 more
TL;DR: Spinal cord abnormalities are prevalent in patients with early-stage MS, have distinct morphologic characteristics, and help to determine dissemination in space at time of diagnosis, according to the most recent diagnostic criteria for multiple sclerosis.
Journal ArticleDOI
Monitoring disease activity in multiple sclerosis using serum neurofilament light protein.
Lenka Novakova,Henrik Zetterberg,Peter Sundström,Markus Axelsson,Mohsen Khademi,Martin Gunnarsson,Clas Malmeström,Anders Svenningsson,Tomas Olsson,Fredrik Piehl,Kaj Blennow,Jan Lycke +11 more
TL;DR: Serum and CSF NFL levels were highly correlated, indicating that blood sampling can replace CSF taps for this particular marker, and Repeated NFL determinations in peripheral blood for detecting axonal damage may represent new possibilities in MS monitoring.
Journal ArticleDOI
Application of the new McDonald criteria to patients with clinically isolated syndromes suggestive of multiple sclerosis
Catherine M. Dalton,P A Brex,Katherine A. Miszkiel,S. J. Hickman,David G. MacManus,Gordon T. Plant,Alan J. Thompson,David Miller +7 more
TL;DR: Using the new McDonald criteria more than doubled the rate of diagnosis of MS within a year of presentation with a clinically isolated syndrome and the high specificity, positive predictive value, and accuracy of the new criteria for clinically definite MS support their clinical relevance.
Journal ArticleDOI
Clinical features and viral serologies in children with multiple sclerosis: a multinational observational study
Brenda Banwell,Lauren B. Krupp,Julia Kennedy,Raymond Tellier,Silvia Tenembaum,Jayne Ness,Anita Belman,Alexei Boiko,Olga Bykova,Emmanuelle Waubant,Jean K. Mah,C.A. Stoian,Marcelo Kremenchutzky,Maria Rita Bardini,Martino Ruggieri,Mary Rensel,Jin S. Hahn,Bianca Weinstock-Guttman,E. Ann Yeh,Kevin Farrell,Mark S. Freedman,Matti Iivanainen,Meri Sevon,Virender Bhan,Marie-Emmanuelle Dilenge,Derek Stephens,Amit Bar-Or +26 more
TL;DR: MS in children might be associated with exposure to EBV, suggesting a possible role for EBV in MS pathobiology and children with MS did not differ from controls in seroprevalence of the other childhood viruses studied.
Journal ArticleDOI
Intractable hiccup and nausea with periaqueductal lesions in neuromyelitis optica
TL;DR: Intractable hiccup and nausea (IHN) was found in eight of 47 cases of relapsing neuromyelitis optica but in none of 130 cases of multiple sclerosis (MS).
References
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Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Journal ArticleDOI
The clinical course of neuromyelitis optica (Devic's syndrome)
TL;DR: Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS, and patients with relapsing optic neuritis and myelitis may have neuromyeliitis opticas rather than MS.
Journal ArticleDOI
Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis.
George A. Schumacher,Gilbert Beebe,Robert F. Kibler,Leonard T. Kurland,John F. Kurtzke,Fletcher McDowell,Benedict Nagler,William A. Sibley,Wallace W. Tourtellotte,Thomas L. Willmon +9 more
TL;DR: Since its etiology and pathogenesis have eluded detection, it is not surprising that therapeutic attempts have been empiric and often unscientific.
Journal ArticleDOI
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
Frederik Barkhof,Massimo Filippi,David Miller,Philip Scheltens,Adriana Campi,Chris H. Polman,Giancarlo Comi,Herman J. Adèr,N. A. Losseff,Jacob Valk +9 more
TL;DR: It is concluded that a four-parameter dichotomized MRI model including gadolinium-enhancement, juxtacortical, infratentorial and periventricular lesions best predicts conversion to clinically definite multiple sclerosis.
Journal ArticleDOI
MRI in the diagnosis of MS A prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT
Donald W. Paty,Joel Oger,Lorne F. Kastrukoff,S. A. Hashimoto,John P. Hooge,Andrew Eisen,K. A. Eisen,S. J. Purves,M. D. Low,V. Brandejs,W. D. Robertson,David Kb Li +11 more
TL;DR: MRI was the best method for demonstrating dissemination in space and laboratory-supported definite MS (LSDMS) could be diagnosed in 85 patients of the total 200, and MRI predicted that diagnosis in 18/19 (95%).
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