Journal ArticleDOI
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
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TLDR
The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.Abstract:
The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with dinical and other paraclinical diagnostic methods. The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including "monosymptomatic" disease suggestive of MS, disease with a typical relapsing-remitting course, and disease with insidious progression, without clear attacks and remissions. Previously used terms such as "clinically definite" and "probable MS" are no longer recommended. The outcome of a diagnostic evaluation is either MS, "possible MS" (for those at risk for MS, but for whom diagnostic evaluation is equivocal), or "not MS."read more
Citations
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Proposed diagnostic criteria and nosology of acute transverse myelitis
G. Barnes,S. Benjamin,J. D. Bowen,N. Cutter,B. J. De Lateur,W. D. Dietrich,M. M. Dowling,J. W. Griffin,Laura K. Hummers,David N. Irani,Philippe G. Jorens,Adam I. Kaplin,J. D. Katz,Douglas A. Kerr,Chitra Krishnan,C. E. Levy,C. Lucchinetti,D. J. Lynn,R. N. Mandler,Justin C. McArthur,John W. McDonald,L. Morrison,Carlos Pardo-Villamizar,Frank S. Pidcock,R. Ransohoff,Karen L. Roos,M. K. Trovato,Timothy Vollmer,S. T. Wegener,Brian G. Weinshenker,Dean M. Wingerchuk +30 more
TL;DR: A set of uniform diagnostic criteria and nosology for ATM is proposed to avoid the confusion that inevitably results when investigators use differing criteria, and a framework is suggested for evaluation of individuals presenting with signs and symptoms of ATM.
Journal ArticleDOI
Minimal neuropsychological assessment of MS patients: a consensus approach.
Ralph H.B. Benedict,Ralph H.B. Benedict,J. S. Fischer,Cate J. Archibald,Peter A. Arnett,William W. Beatty,Julie A. Bobholz,Gordon J. Chelune,John D. Fisk,Dawn Langdon,Lauren S. Caruso,Frederick W. Foley,Nicholas G. LaRocca,Lindsey Vowels,Amy Weinstein,John DeLuca,Stephen M. Rao,Frederick Munschauer +17 more
TL;DR: The Minimal Assessment of Cognitive Function in MS (MACFIMS), a 90-minute NP battery, is composed of seven neuropsychological tests, covering five cognitive domains commonly impaired in MS, and is supplemented by a measure of estimated premorbid cognitive ability.
Journal ArticleDOI
Differential diagnosis of suspected multiple sclerosis: a consensus approach
David Miller,Brian G. Weinshenker,Massimo Filippi,Brenda Banwell,Jeffrey A. Cohen,Mark S. Freedman,SL Galetta,Michael Hutchinson,Richard T. Johnson,Ludwig Kappos,Jun Ichi Kira,Fred D. Lublin,Henry F. McFarland,Xavier Montalban,Hillel Panitch,J. R. Richert,Stephen C. Reingold,Chris H. Polman,Chris H. Polman +18 more
TL;DR: This paper developed guidelines for MS differential diagnosis, focusing on exclusion of potential MS mimics, diagnosis of common initial isolated clinical syndromes, and differentiating between MS and non-MS idiopathic inflammatory demyelinating diseases.
Journal ArticleDOI
Treatment with interferon beta-1b delays conversion to clinically definite and McDonald MS in patients with clinically isolated syndromes
TL;DR: Interferon beta-1b 250 μg subcutaneously every other day delayed conversion to clinically definite multiple sclerosis, and should be considered as a therapeutic option in patients presenting with a first clinical event suggestive of multiple sclerosis.
Journal ArticleDOI
Dysbiosis in the gut microbiota of patients with multiple sclerosis, with a striking depletion of species belonging to clostridia XIVa and IV clusters
Sachiko Miyake,Sangwan Kim,Wataru Suda,Kenshiro Oshima,Masakazu Nakamura,Takako Matsuoka,Norio Chihara,Atsuko Tomita,Wakiro Sato,Seok Won Kim,Hidetoshi Morita,Masahira Hattori,Takashi Yamamura +12 more
TL;DR: Analysis of the bacterial 16S ribosomal RNA (rRNA) gene by using a high-throughput culture-independent pyrosequencing method provided evidence of a moderate dysbiosis in the structure of gut microbiota in patients with MS, and phylogenetic tree analysis revealed that many of the clostridial species associated with MS might be distinct from those broadly associated with autoimmune conditions.
References
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Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Journal ArticleDOI
The clinical course of neuromyelitis optica (Devic's syndrome)
TL;DR: Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS, and patients with relapsing optic neuritis and myelitis may have neuromyeliitis opticas rather than MS.
Journal ArticleDOI
Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis.
George A. Schumacher,Gilbert Beebe,Robert F. Kibler,Leonard T. Kurland,John F. Kurtzke,Fletcher McDowell,Benedict Nagler,William A. Sibley,Wallace W. Tourtellotte,Thomas L. Willmon +9 more
TL;DR: Since its etiology and pathogenesis have eluded detection, it is not surprising that therapeutic attempts have been empiric and often unscientific.
Journal ArticleDOI
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
Frederik Barkhof,Massimo Filippi,David Miller,Philip Scheltens,Adriana Campi,Chris H. Polman,Giancarlo Comi,Herman J. Adèr,N. A. Losseff,Jacob Valk +9 more
TL;DR: It is concluded that a four-parameter dichotomized MRI model including gadolinium-enhancement, juxtacortical, infratentorial and periventricular lesions best predicts conversion to clinically definite multiple sclerosis.
Journal ArticleDOI
MRI in the diagnosis of MS A prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT
Donald W. Paty,Joel Oger,Lorne F. Kastrukoff,S. A. Hashimoto,John P. Hooge,Andrew Eisen,K. A. Eisen,S. J. Purves,M. D. Low,V. Brandejs,W. D. Robertson,David Kb Li +11 more
TL;DR: MRI was the best method for demonstrating dissemination in space and laboratory-supported definite MS (LSDMS) could be diagnosed in 85 patients of the total 200, and MRI predicted that diagnosis in 18/19 (95%).
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