Journal ArticleDOI
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
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TLDR
The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.Abstract:
The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with dinical and other paraclinical diagnostic methods. The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including "monosymptomatic" disease suggestive of MS, disease with a typical relapsing-remitting course, and disease with insidious progression, without clear attacks and remissions. Previously used terms such as "clinically definite" and "probable MS" are no longer recommended. The outcome of a diagnostic evaluation is either MS, "possible MS" (for those at risk for MS, but for whom diagnostic evaluation is equivocal), or "not MS."read more
Citations
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Journal ArticleDOI
Elevated white matter myo-inositol in clinically isolated syndromes suggestive of multiple sclerosis.
K Fernando,Mary A. McLean,Declan T. Chard,D. G. MacManus,Catherine M. Dalton,KA Miszkiel,R M Gordon,Gordon T. Plant,Alan J. Thompson,David Miller +9 more
TL;DR: The concentration of Ins was elevated in CIS NAWM and the early increase may reflect a process of pathogenic importance in multiple sclerosis NAWM, and follow-up studies will investigate whether the increase is of prognostic importance for future relapses and disability.
Journal ArticleDOI
CD226 Gly307Ser association with multiple autoimmune diseases
Jason P. Hafler,Lisa M. Maier,Jason D. Cooper,Vincent Plagnol,Anne Hinks,Matthew J. Simmonds,Helen Stevens,Neil Walker,Barry C. Healy,Joanna M. M. Howson,M Maisuria,Simon Duley,Gillian Coleman,Stephen C. L. Gough,Jane Worthington,Vijay K. Kuchroo,Linda S. Wicker,John A. Todd +17 more
TL;DR: The Ser307 allele of rs763361 in exon 7 of CD226 predisposes to T1D, MS, and possibly AITD and RA, and based on the tag SNP analysis, could be the causal variant.
Journal ArticleDOI
High nationwide prevalence of multiple sclerosis in Sweden
TL;DR: In Sweden, the risk of MS increases with increasing north latitude for both men and women, and the MS prevalence of 188.9/100,000 in Sweden is among the highest nationwide prevalence estimates in the world.
Journal ArticleDOI
Pivotal Advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis
Åsa Andersson,Ruxandra Covacu,Dan Sunnemark,Alexandre I. Danilov,Assunta Dal Bianco,Mohsen Khademi,Erik Wallström,Anna Lobell,Lou Brundin,Hans Lassmann,Robert A. Harris +10 more
TL;DR: It is demonstrated that high mobility group box chromosomal protein 1 (HMGB1), a DNA‐binding protein with proinflammatory properties, is evident in active lesions of MS and experimental autoimmune encephalomyelitis (EAE) and that HMGB1 levels correlate with active inflammation.
Journal ArticleDOI
Antibody to aquaporin 4 in the diagnosis of neuromyelitis optica.
Friedemann Paul,Sven Jarius,Orhan Aktas,Orhan Aktas,Martin Bluthner,Oliver Bauer,Heribert Appelhans,Diego Franciotta,Roberto Bergamaschi,E Littleton,Jacqueline Palace,Hans Peter Seelig,Reinhard Hohlfeld,Angela Vincent,Frauke Zipp +14 more
TL;DR: In the largest series reported so far to the authors' knowledge, AQP4 antibodies in patients with NMO versus various other diseases are quantified, and it is shown that the aquaporin 4 water channel is a target antigen in a majority of patients withNMO.
References
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Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Journal ArticleDOI
The clinical course of neuromyelitis optica (Devic's syndrome)
TL;DR: Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS, and patients with relapsing optic neuritis and myelitis may have neuromyeliitis opticas rather than MS.
Journal ArticleDOI
Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis.
George A. Schumacher,Gilbert Beebe,Robert F. Kibler,Leonard T. Kurland,John F. Kurtzke,Fletcher McDowell,Benedict Nagler,William A. Sibley,Wallace W. Tourtellotte,Thomas L. Willmon +9 more
TL;DR: Since its etiology and pathogenesis have eluded detection, it is not surprising that therapeutic attempts have been empiric and often unscientific.
Journal ArticleDOI
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
Frederik Barkhof,Massimo Filippi,David Miller,Philip Scheltens,Adriana Campi,Chris H. Polman,Giancarlo Comi,Herman J. Adèr,N. A. Losseff,Jacob Valk +9 more
TL;DR: It is concluded that a four-parameter dichotomized MRI model including gadolinium-enhancement, juxtacortical, infratentorial and periventricular lesions best predicts conversion to clinically definite multiple sclerosis.
Journal ArticleDOI
MRI in the diagnosis of MS A prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT
Donald W. Paty,Joel Oger,Lorne F. Kastrukoff,S. A. Hashimoto,John P. Hooge,Andrew Eisen,K. A. Eisen,S. J. Purves,M. D. Low,V. Brandejs,W. D. Robertson,David Kb Li +11 more
TL;DR: MRI was the best method for demonstrating dissemination in space and laboratory-supported definite MS (LSDMS) could be diagnosed in 85 patients of the total 200, and MRI predicted that diagnosis in 18/19 (95%).
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