Journal ArticleDOI
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
W. Ian McDonald,A Compston,Gilles Edan,Donald E. Goodkin,Hans-Peter Hartung,Fred D. Lublin,Henry F. McFarland,Donald W. Paty,Chris H. Polman,Stephen C. Reingold,Magnhild Sandberg-Wollheim,William A. Sibley,Alan J. Thompson,Stanley van den Noort,Brian Y. Weinshenker,Jerry S. Wolinsky +15 more
TLDR
The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including “monosymptomatic” disease suggestive of MS, disease with a typical relapsing‐remitting course, and disease with insidious progression, without clear attacks and remissions.Abstract:
The International Panel on MS Diagnosis presents revised diagnostic criteria for multiple sclerosis (MS). The focus remains on the objective demonstration of dissemination of lesions in both time and space. Magnetic resonance imaging is integrated with dinical and other paraclinical diagnostic methods. The revised criteria facilitate the diagnosis of MS in patients with a variety of presentations, including "monosymptomatic" disease suggestive of MS, disease with a typical relapsing-remitting course, and disease with insidious progression, without clear attacks and remissions. Previously used terms such as "clinically definite" and "probable MS" are no longer recommended. The outcome of a diagnostic evaluation is either MS, "possible MS" (for those at risk for MS, but for whom diagnostic evaluation is equivocal), or "not MS."read more
Citations
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Journal ArticleDOI
Association of MRI metrics and cognitive impairment in radiologically isolated syndromes
Maria Pia Amato,Bahia Hakiki,Benedetta Goretti,Francesca Rossi,Maria Laura Stromillo,Antonio Giorgio,Marco Roscio,A. Ghezzi,Leonello Guidi,Maria Letizia Bartolozzi,Emilio Portaccio,N. De Stefano +11 more
TL;DR: The findings emphasize the importance of including accurate neuropsychological testing and quantitative MR metrics in subjects with RIS suggestive of multiple sclerosis to provide a better characterization of these asymptomatic subjects, potentially useful for diagnostic and therapeutic decisions.
Journal ArticleDOI
Expression of the immune-tolerogenic major histocompatibility molecule HLA-G in multiple sclerosis: implications for CNS immunity.
Heinz Wiendl,Ute Feger,Michel Mittelbronn,Carolyn Jack,Bettina Schreiner,Christine Stadelmann,Jack P. Antel,Wolfgang Brueck,Richard Meyermann,Amit Bar-Or,Bernd C. Kieseier,Michael Weller +11 more
TL;DR: The demonstration of HLA-G and its receptor ILT2 on CNS cells and in areas of microglia activation implicate HLA -G as a contributor to the fundamental mechanisms regulating immune reactivity in the CNS.
Journal ArticleDOI
Validation of the Multiple Sclerosis International Quality of Life questionnaire
Marie-Claude Simeoni,Pascal Auquier,Oscar Fernandez,Peter Flachenecker,S. Stecchi,Cris S. Constantinescu,Egemen Idiman,Alexey Boyko,Antonie Giæver Beiske,Timothy Vollmer,N. Triantafyllou,Paul O'Connor,Yoram Barak,L. Biermann,Edgardo Cristiano,S. Atweh,D. L. Patrick,S. Robitail,N. Ammoury,A. Beresniak,Jean Pelletier +20 more
TL;DR: The validity and reliability of the MusiQoL as an international scale to evaluate QoL in patients with MS are demonstrated and significant correlations were found between activity in daily life scores and clinical indices.
Journal ArticleDOI
Aquaporin-4 antibody–negative neuromyelitis optica: Distinct assay sensitivity–dependent entity
Romain Marignier,Raphaël Bernard-Valnet,Pascale Giraudon,Nicolas Collongues,Caroline Papeix,Hélène Zéphir,Gaëlle Cavillon,Véronique Rogemond,Romain Casey,Bernard Frangoulis,Jérôme De Seze,Sandra Vukusic,Jérôme Honnorat,Christian Confavreux +13 more
TL;DR: A direct relationship between improvement of the sensitivity of the detection method and the distinctiveness and characteristics of the AQP4-Ab–negative NMO group is demonstrated and raises the question of a distinct physiopathology for patients with AQP 4-Ab-negative N MO and of their place in the spectrum of the disease.
Journal ArticleDOI
Introducing polyautoimmunity: secondary autoimmune diseases no longer exist
Adriana Rojas-Villarraga,Jenny Amaya-Amaya,Alberto Rodriguez-Rodriguez,Rubén D. Mantilla,Juan-Manuel Anaya +4 more
TL;DR: The results indicate that coexistence of autoimmune diseases is not uncommon and follows a grouping pattern, and polyautoimmunity is the term proposed for this association of disorders, which encompasses the concept of a common origin for these diseases.
References
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Journal ArticleDOI
New diagnostic criteria for multiple sclerosis: guidelines for research protocols.
Charles M. Poser,Donald W. Paty,Labe C. Scheinberg,W I McDonald,F A Davis,George C. Ebers,Kenneth P. Johnson,William A. Sibley,Donald H. Silberberg,Wallace W. Tourtellotte +9 more
TL;DR: Today there is a need for more exact criteria than existed earlier in order to conduct therapeutic trials in multicenter programs, to compare epidemiological surveys, to evaluate new diagnostic procedures, and to estimate the activity of the disease process in MS.
Journal ArticleDOI
The clinical course of neuromyelitis optica (Devic's syndrome)
TL;DR: Clinical, laboratory, and imaging features generally distinguish neuromyelitis optica from MS, and patients with relapsing optic neuritis and myelitis may have neuromyeliitis opticas rather than MS.
Journal ArticleDOI
Problems of experimental trials of therapy in multiple sclerosis: report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis.
George A. Schumacher,Gilbert Beebe,Robert F. Kibler,Leonard T. Kurland,John F. Kurtzke,Fletcher McDowell,Benedict Nagler,William A. Sibley,Wallace W. Tourtellotte,Thomas L. Willmon +9 more
TL;DR: Since its etiology and pathogenesis have eluded detection, it is not surprising that therapeutic attempts have been empiric and often unscientific.
Journal ArticleDOI
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
Frederik Barkhof,Massimo Filippi,David Miller,Philip Scheltens,Adriana Campi,Chris H. Polman,Giancarlo Comi,Herman J. Adèr,N. A. Losseff,Jacob Valk +9 more
TL;DR: It is concluded that a four-parameter dichotomized MRI model including gadolinium-enhancement, juxtacortical, infratentorial and periventricular lesions best predicts conversion to clinically definite multiple sclerosis.
Journal ArticleDOI
MRI in the diagnosis of MS A prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT
Donald W. Paty,Joel Oger,Lorne F. Kastrukoff,S. A. Hashimoto,John P. Hooge,Andrew Eisen,K. A. Eisen,S. J. Purves,M. D. Low,V. Brandejs,W. D. Robertson,David Kb Li +11 more
TL;DR: MRI was the best method for demonstrating dissemination in space and laboratory-supported definite MS (LSDMS) could be diagnosed in 85 patients of the total 200, and MRI predicted that diagnosis in 18/19 (95%).
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